IRREVERSIBLE INHIBITORS OF TYROSINE KINASES

The present invention relates to pyrimido [5,4-d] pyrimidine compounds of Formula II or a pharmaceutically acceptable salt thereof, wherein Q is and X, E1, E2, E3, R6 and p are as defined herein. The compounds of this invention are irreversible inhibitors of tyrosine kinases and are useful in the tr...

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Bibliographische Detailangaben
Hauptverfasser: ELLEN MYRA DOBRUSIN, JEFFREY B. SMAILL, HOWARD DANIEL HOLLIS SHOWALTER, ALEXANDER JAMES BRIDGES, WILLIAM ALEXANDER DENNY, ANNETTE MARIAN DOHERTY, DENNIS JOSEPH MCNAMARA, DAVID W. FRY, HAIRONG ZHOU H
Format: Patent
Sprache:eng
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Zusammenfassung:The present invention relates to pyrimido [5,4-d] pyrimidine compounds of Formula II or a pharmaceutically acceptable salt thereof, wherein Q is and X, E1, E2, E3, R6 and p are as defined herein. The compounds of this invention are irreversible inhibitors of tyrosine kinases and are useful in the treatment of cancer, atherosclerosis, restenosis, endometriosis and psoriasis.