RESPIRATORY SYNCYTIAL VIRUS REPLICATION INHIBITORS

The present invention concerns compounds of formula prodrugs, N-oxides, addition salts, quaternary amines, metal complexes and stereochemically isomeric forms thereof wherein -a =a -a =a - represents a radical of formula -CH=CH-CH=CH-; -N=CH-CH=CH-; -CH=N-CH=CH-; -CH=CH-N=CH-; - CH=CH-CH=N-; wherein each hydrogen atom may optionally be substituted; Q is a radical of formula wherein Alk is C1-6alkanediyl; Y is a bivalent radical of formula -NR - or -CH(NR R )-; X is NR , S, S(=O), S(=O)2, O, CH2, C(=O), CH(=CH2), CH(OH), CH(CH3), CH(OCH3), CH(SCH3), CH(NR R ), CH2-NR or NR -CH2; X is a direct bond, CH2, C(=O), NR , C1-4alkyl-NR , NR -C1-4alkyl; v is 2 or 3; and whereby each hydrogen in Alk and in (b-6), (b-7) and (b-8), may optionally be replaced by R ; provided that when R is hydroxy or C1-6alkyloxy, then R can not replace a hydrogen atom in the alpha position relative to a nitrogen atom; G is a direct bond or optionally substituted C1-10alkanediyl; R is an optionally substituted bicyclic heterocycle; R is hy