METHODS FOR THE PREPARATION OF MONOMERIC CALICHEAMICIN DERIVATIVE/CARRIER CONJUGATES

A method is provided for preparing monomeric calicheamicin derivative/carrier conjugates with higher drug loading/yield and decreased aggregation. These conjugates are prepared by incubating a calicheamicin derivative and a proteinaceous carrier in a solution comprising a phosphate buffered solution...

Ausführliche Beschreibung

Bibliographische Detailangaben

Hauptverfasser:	HOLLANDER, IRWIN JACK, HAMANN, PHILIP, KUNZ, ARTHUR, KUNSTMANN, MARTIN PAUL
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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