Benzimidazole derivatives process for their preparation and therapeutic application
Benzimidazole derivatives corresponding to the formula (1) (I) in which X is CH or N, R1 is either a hydrogen atom, or a benzyl radical which can bear 1 to 3 substituents chosen from halogen atoms and trifluoromethyl, (C1-4)alkyl, (C1-4)alkoxy, cyano, methylthio, methylsulphinyl and methylsulphonyl...
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| creator | GERARD DEFOSSE PHILIPPE MANOURY JEAN BINET |
| description | Benzimidazole derivatives corresponding to the formula (1) (I) in which X is CH or N, R1 is either a hydrogen atom, or a benzyl radical which can bear 1 to 3 substituents chosen from halogen atoms and trifluoromethyl, (C1-4)alkyl, (C1-4)alkoxy, cyano, methylthio, methylsulphinyl and methylsulphonyl radicals, or a methyl radical bearing a heterocyclic substituent in which the heterocyclic system can be a pyridyl, thienyl or furyl radical and can bear one or more substituents, R2 is a hydrogen atom or a (C1-4)alkyl radical, R3 is a hydrogen atom or a hydroxy radical, and R4 is a hydrogen atom or a (C1-4)alkyl radical, where appropriate, in tautomeric form when R3 is OH. The compounds may be used in treating allergy and histamine-induced inflammation. |
| format | Patent |
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The compounds may be used in treating allergy and histamine-induced inflammation.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1999</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNisEKwjAQBXPxIOo_7A8IrdKDRxWl4FHvZUlecSFNliT20K-3ih_gaWBmluZ-QphkEMdT9CCHJCMXGZFJU7TImfqYqDwhaTZQTnOOgTi4j02seBWxxKpe7LetzaJnn7H5cWXoenmc2y00dsjKFgGla291VTXNYXes938sb4FhOSk</recordid><startdate>19990115</startdate><enddate>19990115</enddate><creator>GERARD DEFOSSE</creator><creator>PHILIPPE MANOURY</creator><creator>JEAN BINET</creator><scope>EVB</scope></search><sort><creationdate>19990115</creationdate><title>Benzimidazole derivatives process for their preparation and therapeutic application</title><author>GERARD DEFOSSE ; PHILIPPE MANOURY ; JEAN BINET</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_HK1005592A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1999</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>GERARD DEFOSSE</creatorcontrib><creatorcontrib>PHILIPPE MANOURY</creatorcontrib><creatorcontrib>JEAN BINET</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>GERARD DEFOSSE</au><au>PHILIPPE MANOURY</au><au>JEAN BINET</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Benzimidazole derivatives process for their preparation and therapeutic application</title><date>1999-01-15</date><risdate>1999</risdate><abstract>Benzimidazole derivatives corresponding to the formula (1) (I) in which X is CH or N, R1 is either a hydrogen atom, or a benzyl radical which can bear 1 to 3 substituents chosen from halogen atoms and trifluoromethyl, (C1-4)alkyl, (C1-4)alkoxy, cyano, methylthio, methylsulphinyl and methylsulphonyl radicals, or a methyl radical bearing a heterocyclic substituent in which the heterocyclic system can be a pyridyl, thienyl or furyl radical and can bear one or more substituents, R2 is a hydrogen atom or a (C1-4)alkyl radical, R3 is a hydrogen atom or a hydroxy radical, and R4 is a hydrogen atom or a (C1-4)alkyl radical, where appropriate, in tautomeric form when R3 is OH. The compounds may be used in treating allergy and histamine-induced inflammation.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Benzimidazole derivatives process for their preparation and therapeutic application |
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