3-(5-Tetrazolyl-benzyl)amino-piperidine derivatives and antagonists of tachykinins

PCT No. PCT/EP94/03129 Sec. 371 Date Mar. 21, 1996 Sec. 102(e) Date Mar. 21, 1996 PCT Filed Sep. 20, 1994 PCT Pub. No. WO95/08549 PCT Pub. Date Mar. 30, 1995The present invention relates to piperidine derivatives of formula (I) (I) wherein R1 is a C1-4alkoxy group; R2 is R3 is a hydrogen or halogen...

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Hauptverfasser:	TANIA HUBBARD, GERARD MARTIN PAUL GIBLIN, MICHAEL MENTEITH HANN, DAVID MIDDLEMISS, STEPHEN PAUL WATSON, DUNCAN ROBERT ARMOUR, ALAN NAYLOR, NEIL ANTHONY PEGG, XIAO-QING LEWELL, BRIAN EVANS, MARIA VICTORIA VINADER
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	PCT No. PCT/EP94/03129 Sec. 371 Date Mar. 21, 1996 Sec. 102(e) Date Mar. 21, 1996 PCT Filed Sep. 20, 1994 PCT Pub. No. WO95/08549 PCT Pub. Date Mar. 30, 1995The present invention relates to piperidine derivatives of formula (I) (I) wherein R1 is a C1-4alkoxy group; R2 is R3 is a hydrogen or halogen atom; R4 and R5 may each independently represent a hydrogen or halogen atom, or a C1-4alkyl, C1-4alkoxy or trifluoromethyl group; R6 is a hydrogen atom, a C1-4alkyl, (CH2)mcyclopropyl, -S(O)nC1-4alkyl, phenyl, NR7R8, CH2C(O)CF3 or trifluoromethyl group; R7 and R8 may each independently represent a hydrogen atom, or a C1-4alkyl or acyl group; x represents zero or 1; n represents zero, 1 or 2; m represents zero or 1; and pharmaceutically acceptable salts and solvates thereof; to processes for their preparation; and their use in the treatment of conditions mediated by tachykinins.