GR79640

GR79640

Pyrazole derivatives of formula (I): wherein R min is hydrogen or methyl; Ar is pyridyl, thienyl, or optionally substituted phenyl; X is NH2, H, OH, halogen or C1-3 alkyl; and R is OH, OM, O-alk, NH2, NH-alk, N(alk)2 or N-alken-N-(alk)2; wherein alk is C1-5 alkyl; alken is (CH2)2 or (CH2)3 and M is...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: J.R. BECK, R.P. GAJEWSKI, R.E. HACKLER
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Pyrazole derivatives of formula (I): wherein R min is hydrogen or methyl; Ar is pyridyl, thienyl, or optionally substituted phenyl; X is NH2, H, OH, halogen or C1-3 alkyl; and R is OH, OM, O-alk, NH2, NH-alk, N(alk)2 or N-alken-N-(alk)2; wherein alk is C1-5 alkyl; alken is (CH2)2 or (CH2)3 and M is a non-toxic cation; are useful in lowering blood urate levels in mammals.