PIPERIDINE DERIVATIVES AS DIURETIC

PIPERIDINE DERIVATIVES AS DIURETIC

A diuretic compound of Formula I or pharmaceutically acceptable salt thereof where R1 is a C1-6 alkyl; R2 is halogen, C1-4 alkyl; and R3 is C1-4 alkoxy are disclosed, preferably, benzamide, 3-chloro-N-(2-ethyl-2-(3-methoxyphenyl)-4-(1-piperidinyl)butyl), monohydrochloride. The compounds are effectiv...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: JACOBSEN, ERIC, JON, HUMPHREY, STEPHEN, J, CURRY, JAMES, T
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:A diuretic compound of Formula I or pharmaceutically acceptable salt thereof where R1 is a C1-6 alkyl; R2 is halogen, C1-4 alkyl; and R3 is C1-4 alkoxy are disclosed, preferably, benzamide, 3-chloro-N-(2-ethyl-2-(3-methoxyphenyl)-4-(1-piperidinyl)butyl), monohydrochloride. The compounds are effective diuretics which increase the excretion of water with little increase in electrolyte excretion.