DIOXO-THIOPYRANO-PYRIDINE CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS MEDICAMENTS

PCT No. PCT/EP95/02546 Sec. 371 Date Jan. 6, 1997 Sec. 102(e) Date Jan. 6, 1997 PCT Filed Jun. 30, 1995 PCT Pub. No. WO96/02547 PCT Pub. Date Feb. 1, 1996Dioxo-thiopyrano-pyridine-carboxylic acid derivatives are prepared by reacting appropriate aldehydes with aminocrotonic acid esters and tetrahydro...

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Hauptverfasser: JUNGE, BODO, DE VRY, JEAN-MARIE-VIKTOR, URBAHNS, KLAUS, HEINE, HANS-GEORG, SCHOHE-LOOP, RUDOLF, WITTKA, REILINDE, GLASER, THOMAS, SOMMERMEYER, HENNING DR
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creator JUNGE, BODO
DE VRY, JEAN-MARIE-VIKTOR
URBAHNS, KLAUS
HEINE, HANS-GEORG
SCHOHE-LOOP, RUDOLF
WITTKA, REILINDE
GLASER, THOMAS
SOMMERMEYER, HENNING DR
description PCT No. PCT/EP95/02546 Sec. 371 Date Jan. 6, 1997 Sec. 102(e) Date Jan. 6, 1997 PCT Filed Jun. 30, 1995 PCT Pub. No. WO96/02547 PCT Pub. Date Feb. 1, 1996Dioxo-thiopyrano-pyridine-carboxylic acid derivatives are prepared by reacting appropriate aldehydes with aminocrotonic acid esters and tetrahydrothiopyran-3-one-1,1-dioxide and oxidizing the products thus obtained. The substances according to the invention can be employed as active substances in medicaments. They are selective modulators of the calcium-dependent potassium channels of high conductivity.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title DIOXO-THIOPYRANO-PYRIDINE CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS MEDICAMENTS
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