3-(5-TETRAZOLYL-BENZYL)AMINO-PIPERIDINE DERIVATIVES AND ANTAGONISTS OF TACHYKININS
PCT No. PCT/EP94/03129 Sec. 371 Date Mar. 21, 1996 Sec. 102(e) Date Mar. 21, 1996 PCT Filed Sep. 20, 1994 PCT Pub. No. WO95/08549 PCT Pub. Date Mar. 30, 1995The present invention relates to piperidine derivatives of formula (I) (I) wherein R1 is a C1-4alkoxy group; R2 is R3 is a hydrogen or halogen...
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| creator | HANN, MICHAEL, MENTEITH ARMOUR, DUNCAN, ROBERT EVANS, BRIAN LEWELL, XIAO-QING MIDDLEMISS, DAVID VINADER, MARIA, VICTORIA GIBLIN, GERARD, MARTIN, PAUL PEGG, NEIL, ANTHONY WATSON, STEPHEN, PAUL NAYLOR, ALAN HUBBARD, TANIA |
| description | PCT No. PCT/EP94/03129 Sec. 371 Date Mar. 21, 1996 Sec. 102(e) Date Mar. 21, 1996 PCT Filed Sep. 20, 1994 PCT Pub. No. WO95/08549 PCT Pub. Date Mar. 30, 1995The present invention relates to piperidine derivatives of formula (I) (I) wherein R1 is a C1-4alkoxy group; R2 is R3 is a hydrogen or halogen atom; R4 and R5 may each independently represent a hydrogen or halogen atom, or a C1-4alkyl, C1-4alkoxy or trifluoromethyl group; R6 is a hydrogen atom, a C1-4alkyl, (CH2)mcyclopropyl, -S(O)nC1-4alkyl, phenyl, NR7R8, CH2C(O)CF3 or trifluoromethyl group; R7 and R8 may each independently represent a hydrogen atom, or a C1-4alkyl or acyl group; x represents zero or 1; n represents zero, 1 or 2; m represents zero or 1; and pharmaceutically acceptable salts and solvates thereof; to processes for their preparation; and their use in the treatment of conditions mediated by tachykinins. |
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No. WO95/08549 PCT Pub. Date Mar. 30, 1995The present invention relates to piperidine derivatives of formula (I) (I) wherein R1 is a C1-4alkoxy group; R2 is R3 is a hydrogen or halogen atom; R4 and R5 may each independently represent a hydrogen or halogen atom, or a C1-4alkyl, C1-4alkoxy or trifluoromethyl group; R6 is a hydrogen atom, a C1-4alkyl, (CH2)mcyclopropyl, -S(O)nC1-4alkyl, phenyl, NR7R8, CH2C(O)CF3 or trifluoromethyl group; R7 and R8 may each independently represent a hydrogen atom, or a C1-4alkyl or acyl group; x represents zero or 1; n represents zero, 1 or 2; m represents zero or 1; and pharmaceutically acceptable salts and solvates thereof; to processes for their preparation; and their use in the treatment of conditions mediated by tachykinins.</description><edition>6</edition><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1999</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19990528&DB=EPODOC&CC=GR&NR=3029354T3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,781,886,25569,76552</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19990528&DB=EPODOC&CC=GR&NR=3029354T3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HANN, MICHAEL, MENTEITH</creatorcontrib><creatorcontrib>ARMOUR, DUNCAN, ROBERT</creatorcontrib><creatorcontrib>EVANS, BRIAN</creatorcontrib><creatorcontrib>LEWELL, XIAO-QING</creatorcontrib><creatorcontrib>MIDDLEMISS, DAVID</creatorcontrib><creatorcontrib>VINADER, MARIA, VICTORIA</creatorcontrib><creatorcontrib>GIBLIN, GERARD, MARTIN, PAUL</creatorcontrib><creatorcontrib>PEGG, NEIL, ANTHONY</creatorcontrib><creatorcontrib>WATSON, STEPHEN, PAUL</creatorcontrib><creatorcontrib>NAYLOR, ALAN</creatorcontrib><creatorcontrib>HUBBARD, TANIA</creatorcontrib><title>3-(5-TETRAZOLYL-BENZYL)AMINO-PIPERIDINE DERIVATIVES AND ANTAGONISTS OF TACHYKININS</title><description>PCT No. PCT/EP94/03129 Sec. 371 Date Mar. 21, 1996 Sec. 102(e) Date Mar. 21, 1996 PCT Filed Sep. 20, 1994 PCT Pub. 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Date Mar. 30, 1995The present invention relates to piperidine derivatives of formula (I) (I) wherein R1 is a C1-4alkoxy group; R2 is R3 is a hydrogen or halogen atom; R4 and R5 may each independently represent a hydrogen or halogen atom, or a C1-4alkyl, C1-4alkoxy or trifluoromethyl group; R6 is a hydrogen atom, a C1-4alkyl, (CH2)mcyclopropyl, -S(O)nC1-4alkyl, phenyl, NR7R8, CH2C(O)CF3 or trifluoromethyl group; R7 and R8 may each independently represent a hydrogen atom, or a C1-4alkyl or acyl group; x represents zero or 1; n represents zero, 1 or 2; m represents zero or 1; and pharmaceutically acceptable salts and solvates thereof; to processes for their preparation; and their use in the treatment of conditions mediated by tachykinins.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1999</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZAgy1tUw1Q1xDQlyjPL3ifTRdXL1i4r00XT09fTz1w3wDHAN8nTx9HNVcAEywhxDPMNcgxUc_VyAOMTR3d_PMzgkWMHfTSHE0dkj0tvTz9MvmIeBNS0xpziVF0pzMyi6uYY4e-imFuTHpxYXJCan5qWWxLsHGRsYWRqbmoSEGBsTowYA7PIwRw</recordid><startdate>19990528</startdate><enddate>19990528</enddate><creator>HANN, MICHAEL, MENTEITH</creator><creator>ARMOUR, DUNCAN, ROBERT</creator><creator>EVANS, BRIAN</creator><creator>LEWELL, XIAO-QING</creator><creator>MIDDLEMISS, DAVID</creator><creator>VINADER, MARIA, VICTORIA</creator><creator>GIBLIN, GERARD, MARTIN, PAUL</creator><creator>PEGG, NEIL, ANTHONY</creator><creator>WATSON, STEPHEN, PAUL</creator><creator>NAYLOR, ALAN</creator><creator>HUBBARD, TANIA</creator><scope>EVB</scope></search><sort><creationdate>19990528</creationdate><title>3-(5-TETRAZOLYL-BENZYL)AMINO-PIPERIDINE DERIVATIVES AND ANTAGONISTS OF TACHYKININS</title><author>HANN, MICHAEL, MENTEITH ; ARMOUR, DUNCAN, ROBERT ; EVANS, BRIAN ; LEWELL, XIAO-QING ; MIDDLEMISS, DAVID ; VINADER, MARIA, VICTORIA ; GIBLIN, GERARD, MARTIN, PAUL ; PEGG, NEIL, ANTHONY ; WATSON, STEPHEN, PAUL ; NAYLOR, ALAN ; HUBBARD, TANIA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_GR3029354TT33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1999</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>HANN, MICHAEL, MENTEITH</creatorcontrib><creatorcontrib>ARMOUR, DUNCAN, ROBERT</creatorcontrib><creatorcontrib>EVANS, BRIAN</creatorcontrib><creatorcontrib>LEWELL, XIAO-QING</creatorcontrib><creatorcontrib>MIDDLEMISS, DAVID</creatorcontrib><creatorcontrib>VINADER, MARIA, VICTORIA</creatorcontrib><creatorcontrib>GIBLIN, GERARD, MARTIN, PAUL</creatorcontrib><creatorcontrib>PEGG, NEIL, ANTHONY</creatorcontrib><creatorcontrib>WATSON, STEPHEN, PAUL</creatorcontrib><creatorcontrib>NAYLOR, ALAN</creatorcontrib><creatorcontrib>HUBBARD, TANIA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HANN, MICHAEL, MENTEITH</au><au>ARMOUR, DUNCAN, ROBERT</au><au>EVANS, BRIAN</au><au>LEWELL, XIAO-QING</au><au>MIDDLEMISS, DAVID</au><au>VINADER, MARIA, VICTORIA</au><au>GIBLIN, GERARD, MARTIN, PAUL</au><au>PEGG, NEIL, ANTHONY</au><au>WATSON, STEPHEN, PAUL</au><au>NAYLOR, ALAN</au><au>HUBBARD, TANIA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>3-(5-TETRAZOLYL-BENZYL)AMINO-PIPERIDINE DERIVATIVES AND ANTAGONISTS OF TACHYKININS</title><date>1999-05-28</date><risdate>1999</risdate><abstract>PCT No. PCT/EP94/03129 Sec. 371 Date Mar. 21, 1996 Sec. 102(e) Date Mar. 21, 1996 PCT Filed Sep. 20, 1994 PCT Pub. No. WO95/08549 PCT Pub. Date Mar. 30, 1995The present invention relates to piperidine derivatives of formula (I) (I) wherein R1 is a C1-4alkoxy group; R2 is R3 is a hydrogen or halogen atom; R4 and R5 may each independently represent a hydrogen or halogen atom, or a C1-4alkyl, C1-4alkoxy or trifluoromethyl group; R6 is a hydrogen atom, a C1-4alkyl, (CH2)mcyclopropyl, -S(O)nC1-4alkyl, phenyl, NR7R8, CH2C(O)CF3 or trifluoromethyl group; R7 and R8 may each independently represent a hydrogen atom, or a C1-4alkyl or acyl group; x represents zero or 1; n represents zero, 1 or 2; m represents zero or 1; and pharmaceutically acceptable salts and solvates thereof; to processes for their preparation; and their use in the treatment of conditions mediated by tachykinins.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | 3-(5-TETRAZOLYL-BENZYL)AMINO-PIPERIDINE DERIVATIVES AND ANTAGONISTS OF TACHYKININS |
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