Perfusion manifold assembly
A first drop 23 protruding from a first fluid port on a first mating surface 10 may be brought into contact with a second fluid droplet 22 protruding from a second fluid port in a microfluidic device 16. Upon contact, fluid may flow from a fluid source, through the first fluid port, and then into th...
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| creator | Daniel Levner Petrus Wilhelmus Martinus van Ruijven Christopher David Hinojosa Guy Robert Thompson III Joshua Gomes Doug Sabin Josiah Daniel Sliz Jacob Freake Matthew Daniel Solomon Patrick Sean Tuohy Norman Wen Christian Alexander Potzner |
| description | A first drop 23 protruding from a first fluid port on a first mating surface 10 may be brought into contact with a second fluid droplet 22 protruding from a second fluid port in a microfluidic device 16. Upon contact, fluid may flow from a fluid source, through the first fluid port, and then into the second fluid port of the microfluidic device. A region surrounding the first fluid port may resist wetting and be hydrophobic. Surfaces may comprise hydrophilic regions, or geometric features such as a ridge, mount, gasket or depression to retain or confine droplets. The drop-to-drop connection or coupling may reduce the chance of bubbles becoming trapped during connection of ports of substrates. A perfusion manifold assembly may allow perfusion of a microfluidic device, such as an organ on a chip microfluidic device, comprising cells that mimic cells in an organ of the body; using valves. |
| format | Patent |
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Upon contact, fluid may flow from a fluid source, through the first fluid port, and then into the second fluid port of the microfluidic device. A region surrounding the first fluid port may resist wetting and be hydrophobic. Surfaces may comprise hydrophilic regions, or geometric features such as a ridge, mount, gasket or depression to retain or confine droplets. The drop-to-drop connection or coupling may reduce the chance of bubbles becoming trapped during connection of ports of substrates. 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Upon contact, fluid may flow from a fluid source, through the first fluid port, and then into the second fluid port of the microfluidic device. A region surrounding the first fluid port may resist wetting and be hydrophobic. Surfaces may comprise hydrophilic regions, or geometric features such as a ridge, mount, gasket or depression to retain or confine droplets. The drop-to-drop connection or coupling may reduce the chance of bubbles becoming trapped during connection of ports of substrates. A perfusion manifold assembly may allow perfusion of a microfluidic device, such as an organ on a chip microfluidic device, comprising cells that mimic cells in an organ of the body; using valves.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY BEER BIOCHEMISTRY CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE CHEMISTRY ENZYMOLOGY METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL SPIRITS TRANSPORTING VINEGAR WINE |
| title | Perfusion manifold assembly |
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