New polymorph and new path to synthesize tafamidis

A process for the production of 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid (2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol F (Tafemidis meglumine) comprising the step of cyclization of 4-(3,5-dichlorobenzamido)-3-hydroxybenzoic acid D in the presence of acetic acid and a sulfonic...

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Hauptverfasser:	Kristine Nerkararyan, Grigor Gevorgyan, Karine Barseghyan, Vahuni Karapetyan, Thomas Maier, Davit Hambardzumyan
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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