Treatment for enhancing joint lubrication
The present invention is directed to a method of altering the amount or composition of synovial fluids secreted from joints in a subject in need of such treatment. The method comprises administering to a subject a nicotinic receptor agonist such as nicotine, transmetanicotine, epibatidine, lobeline,...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Patent |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | MATTHEW S COWLEN BENJAMIN R YERXA |
| description | The present invention is directed to a method of altering the amount or composition of synovial fluids secreted from joints in a subject in need of such treatment. The method comprises administering to a subject a nicotinic receptor agonist such as nicotine, transmetanicotine, epibatidine, lobeline, and imidacloprid; analogs of such nicotinic agonists; and pyridol and para-alkylthiophenol derivatives in an amount effective to stimulate synovial secretions. Pharmaceutical formulations and methods of their production and administration are also disclosed. The invention is useful for treating disorders associated with joint stiffness, including but not limited to, osteoarthritis and following arthroplastic surgery. Preferred compounds are selected from nicotine, anabasine, 5-ethynylnicotine, trans-metanicotine, 3-ethoxy trans-metanicotine, epibatidine derivatives, ABT-089, ABT-594, SIB-1553A, lobeline analogues, ABT-418, DMXB, DBO-083, imidacloprid and desnitro-imidacloprid. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_GB2381750A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>GB2381750A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_GB2381750A3</originalsourceid><addsrcrecordid>eNrjZNAMKUpNLMlNzStRSMsvUkjNy0jMS87MS1fIys8EiuWUJhVlJieWZObn8TCwpiXmFKfyQmluBnk31xBnD93Ugvz41OKCxOTUvNSSeHcnI2MLQ3NTA0djwioAgCEoFg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Treatment for enhancing joint lubrication</title><source>esp@cenet</source><creator>MATTHEW S COWLEN ; BENJAMIN R YERXA</creator><creatorcontrib>MATTHEW S COWLEN ; BENJAMIN R YERXA</creatorcontrib><description>The present invention is directed to a method of altering the amount or composition of synovial fluids secreted from joints in a subject in need of such treatment. The method comprises administering to a subject a nicotinic receptor agonist such as nicotine, transmetanicotine, epibatidine, lobeline, and imidacloprid; analogs of such nicotinic agonists; and pyridol and para-alkylthiophenol derivatives in an amount effective to stimulate synovial secretions. Pharmaceutical formulations and methods of their production and administration are also disclosed. The invention is useful for treating disorders associated with joint stiffness, including but not limited to, osteoarthritis and following arthroplastic surgery. Preferred compounds are selected from nicotine, anabasine, 5-ethynylnicotine, trans-metanicotine, 3-ethoxy trans-metanicotine, epibatidine derivatives, ABT-089, ABT-594, SIB-1553A, lobeline analogues, ABT-418, DMXB, DBO-083, imidacloprid and desnitro-imidacloprid.</description><edition>7</edition><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2003</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20030514&DB=EPODOC&CC=GB&NR=2381750A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76294</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20030514&DB=EPODOC&CC=GB&NR=2381750A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MATTHEW S COWLEN</creatorcontrib><creatorcontrib>BENJAMIN R YERXA</creatorcontrib><title>Treatment for enhancing joint lubrication</title><description>The present invention is directed to a method of altering the amount or composition of synovial fluids secreted from joints in a subject in need of such treatment. The method comprises administering to a subject a nicotinic receptor agonist such as nicotine, transmetanicotine, epibatidine, lobeline, and imidacloprid; analogs of such nicotinic agonists; and pyridol and para-alkylthiophenol derivatives in an amount effective to stimulate synovial secretions. Pharmaceutical formulations and methods of their production and administration are also disclosed. The invention is useful for treating disorders associated with joint stiffness, including but not limited to, osteoarthritis and following arthroplastic surgery. Preferred compounds are selected from nicotine, anabasine, 5-ethynylnicotine, trans-metanicotine, 3-ethoxy trans-metanicotine, epibatidine derivatives, ABT-089, ABT-594, SIB-1553A, lobeline analogues, ABT-418, DMXB, DBO-083, imidacloprid and desnitro-imidacloprid.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2003</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNAMKUpNLMlNzStRSMsvUkjNy0jMS87MS1fIys8EiuWUJhVlJieWZObn8TCwpiXmFKfyQmluBnk31xBnD93Ugvz41OKCxOTUvNSSeHcnI2MLQ3NTA0djwioAgCEoFg</recordid><startdate>20030514</startdate><enddate>20030514</enddate><creator>MATTHEW S COWLEN</creator><creator>BENJAMIN R YERXA</creator><scope>EVB</scope></search><sort><creationdate>20030514</creationdate><title>Treatment for enhancing joint lubrication</title><author>MATTHEW S COWLEN ; BENJAMIN R YERXA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_GB2381750A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2003</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>MATTHEW S COWLEN</creatorcontrib><creatorcontrib>BENJAMIN R YERXA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MATTHEW S COWLEN</au><au>BENJAMIN R YERXA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Treatment for enhancing joint lubrication</title><date>2003-05-14</date><risdate>2003</risdate><abstract>The present invention is directed to a method of altering the amount or composition of synovial fluids secreted from joints in a subject in need of such treatment. The method comprises administering to a subject a nicotinic receptor agonist such as nicotine, transmetanicotine, epibatidine, lobeline, and imidacloprid; analogs of such nicotinic agonists; and pyridol and para-alkylthiophenol derivatives in an amount effective to stimulate synovial secretions. Pharmaceutical formulations and methods of their production and administration are also disclosed. The invention is useful for treating disorders associated with joint stiffness, including but not limited to, osteoarthritis and following arthroplastic surgery. Preferred compounds are selected from nicotine, anabasine, 5-ethynylnicotine, trans-metanicotine, 3-ethoxy trans-metanicotine, epibatidine derivatives, ABT-089, ABT-594, SIB-1553A, lobeline analogues, ABT-418, DMXB, DBO-083, imidacloprid and desnitro-imidacloprid.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng |
| recordid | cdi_epo_espacenet_GB2381750A |
| source | esp@cenet |
| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Treatment for enhancing joint lubrication |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T21%3A20%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=MATTHEW%20S%20COWLEN&rft.date=2003-05-14&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EGB2381750A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |