Non-steroidal ligands for the estrogen receptor
Triphenyl-alkene derivatives of formula (I) are new. R1 = (CH2)nCR5=CR6R7; R2, R3 = H, Me, OH, OMe, OEt or i-Pr; R4 = CN, NO2, Me, Et, CH2CH2Y or Y; R5, R6 = H, 1-4C alkyl, 2-4C alkenyl, 2-4C alkynyl, X-(1-3C)alkyl, X-(2-4C)alkenyl, X-(2-4C)alkynyl or Y; R7 = CN, 1-4C hydroxyalkyl, CONR10R11, CONR12...
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| creator | TIMOTHY MARK WILLSON |
| description | Triphenyl-alkene derivatives of formula (I) are new. R1 = (CH2)nCR5=CR6R7; R2, R3 = H, Me, OH, OMe, OEt or i-Pr; R4 = CN, NO2, Me, Et, CH2CH2Y or Y; R5, R6 = H, 1-4C alkyl, 2-4C alkenyl, 2-4C alkynyl, X-(1-3C)alkyl, X-(2-4C)alkenyl, X-(2-4C)alkynyl or Y; R7 = CN, 1-4C hydroxyalkyl, CONR10R11, CONR12R13, CONHCH2R12, C(NH2)NOR12, SOR12, SO2OR12, SO2NHCO2R12, PO3R12, PO(NR12R13)(NR12R13), PO(NR12R13)(OR14), CONR12(CH2)qOMe, CONR12(CH2)qNR8R9 or oxadiazolyl substituted with Me; R8, R9 = H, 1-7C alkyl, 3-7C cycloalkyl, 1-7C alkoxy, (1-7C)alkyl-Y or phenyl; R10, R11 = Me or Et; or NR10R11 = morpholino; R12-R14 = H, 1-12C alkyl, 2-12C alkenyl, 2-12C alkynyl, 1-12C alkoxy, 2-12C alkenyloxy, 2-12C alkynyloxy, 3-7C cycloalkenyl, 3-7C cycloalkenyl (sic), linear and cyclic heteroalkyl, aryl, heteroaryl or Y; X = O or S; Y = halo; n = 0-2; and q = 1-12. |
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R1 = (CH2)nCR5=CR6R7; R2, R3 = H, Me, OH, OMe, OEt or i-Pr; R4 = CN, NO2, Me, Et, CH2CH2Y or Y; R5, R6 = H, 1-4C alkyl, 2-4C alkenyl, 2-4C alkynyl, X-(1-3C)alkyl, X-(2-4C)alkenyl, X-(2-4C)alkynyl or Y; R7 = CN, 1-4C hydroxyalkyl, CONR10R11, CONR12R13, CONHCH2R12, C(NH2)NOR12, SOR12, SO2OR12, SO2NHCO2R12, PO3R12, PO(NR12R13)(NR12R13), PO(NR12R13)(OR14), CONR12(CH2)qOMe, CONR12(CH2)qNR8R9 or oxadiazolyl substituted with Me; R8, R9 = H, 1-7C alkyl, 3-7C cycloalkyl, 1-7C alkoxy, (1-7C)alkyl-Y or phenyl; R10, R11 = Me or Et; or NR10R11 = morpholino; R12-R14 = H, 1-12C alkyl, 2-12C alkenyl, 2-12C alkynyl, 1-12C alkoxy, 2-12C alkenyloxy, 2-12C alkynyloxy, 3-7C cycloalkenyl, 3-7C cycloalkenyl (sic), linear and cyclic heteroalkyl, aryl, heteroaryl or Y; X = O or S; Y = halo; n = 0-2; and q = 1-12.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2002</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZND3y8_TLS5JLcrPTEnMUcjJTE_MSylWSMsvUijJSFVILS4pyk9PzVMoSk1OLSjJL-JhYE1LzClO5YXS3Azybq4hzh66qQX58anFBYnJqXmpJfHuTkbGJiamFpZOxoRVAACSaCo-</recordid><startdate>20020206</startdate><enddate>20020206</enddate><creator>TIMOTHY MARK WILLSON</creator><scope>EVB</scope></search><sort><creationdate>20020206</creationdate><title>Non-steroidal ligands for the estrogen receptor</title><author>TIMOTHY MARK WILLSON</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_GB2344589B3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2002</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>TIMOTHY MARK WILLSON</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>TIMOTHY MARK WILLSON</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Non-steroidal ligands for the estrogen receptor</title><date>2002-02-06</date><risdate>2002</risdate><abstract>Triphenyl-alkene derivatives of formula (I) are new. R1 = (CH2)nCR5=CR6R7; R2, R3 = H, Me, OH, OMe, OEt or i-Pr; R4 = CN, NO2, Me, Et, CH2CH2Y or Y; R5, R6 = H, 1-4C alkyl, 2-4C alkenyl, 2-4C alkynyl, X-(1-3C)alkyl, X-(2-4C)alkenyl, X-(2-4C)alkynyl or Y; R7 = CN, 1-4C hydroxyalkyl, CONR10R11, CONR12R13, CONHCH2R12, C(NH2)NOR12, SOR12, SO2OR12, SO2NHCO2R12, PO3R12, PO(NR12R13)(NR12R13), PO(NR12R13)(OR14), CONR12(CH2)qOMe, CONR12(CH2)qNR8R9 or oxadiazolyl substituted with Me; R8, R9 = H, 1-7C alkyl, 3-7C cycloalkyl, 1-7C alkoxy, (1-7C)alkyl-Y or phenyl; R10, R11 = Me or Et; or NR10R11 = morpholino; R12-R14 = H, 1-12C alkyl, 2-12C alkenyl, 2-12C alkynyl, 1-12C alkoxy, 2-12C alkenyloxy, 2-12C alkynyloxy, 3-7C cycloalkenyl, 3-7C cycloalkenyl (sic), linear and cyclic heteroalkyl, aryl, heteroaryl or Y; X = O or S; Y = halo; n = 0-2; and q = 1-12.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Non-steroidal ligands for the estrogen receptor |
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