INDOLE DERIVATIVES

Novel compounds of formula (I): wherein R, is H, C1-6 alkyl, C3-7 cycloalkyl, phenyl, or phenyl (C1-4) alkyl, R2 and R3 are independently H or C1-3 alkyl, R4 and R5 are independently H, C1-3 alkyl or 2-propenyl; A is -CO- or -SO2-, n is 2 to 5, provided that R1 is not H when A is -SO2-, and physiolo...

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Bibliographische Detailangaben
Hauptverfasser: DAVID EDMUND BAYS, KEITH MILLS, IAN HAROLD COATES, MICHAEL DENNIS DOWLE, COLIN FREDERICK WEBB
Format: Patent
Sprache:eng
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Zusammenfassung:Novel compounds of formula (I): wherein R, is H, C1-6 alkyl, C3-7 cycloalkyl, phenyl, or phenyl (C1-4) alkyl, R2 and R3 are independently H or C1-3 alkyl, R4 and R5 are independently H, C1-3 alkyl or 2-propenyl; A is -CO- or -SO2-, n is 2 to 5, provided that R1 is not H when A is -SO2-, and physiologically acceptable salts and solvates e.g. hydrates thereof have potent and selective vasoconstrictor activity and are indicated as useful for the treatment of migraine. Intermediates of formula II are also claimed.