Method of preparing liposomes and products produced thereby

A method for preparing stable liposome precursors in the form of water-soluble carrier materials coated with thin films of liposome components includes dissolving at least one liposome-forming amphipathic lipid, optionally at least one biologically active compound, and, optionally, at least one adju...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: PETER TIMMINS, NICHOLAS I PAYNE, CHERYL VANESSA GROOM
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:A method for preparing stable liposome precursors in the form of water-soluble carrier materials coated with thin films of liposome components includes dissolving at least one liposome-forming amphipathic lipid, optionally at least one biologically active compound, and, optionally, at least one adjuvant in a suitable solvent and employing the resulting solution to coat particles of a water-soluble carrier material which is insoluble in the solvent, such as sorbitol, to form thin films of liposome components thereon. Upon exposing the coated carrier material to water, the thin films of liposome components hydrate and the carrier material dissolves to give liposome preparations. The active compound may be amphotericin B.