(E)-5-(2-BROMOVINYL)-URIDINE, ITS DERIVATIVES AND A PROCESS FOR THE PREPARATION THEREOF
The invention relates to (E)-5-(2-bromovinyl)-uridine and its derivatives of general formula VI, VI wherein R1 stands for a hydrogen atom, C1-8 alkanoyl group, benzoyl group or a benzoyl group substituted in para position either with a C1-4 alkyl group or a halogen atom, and a process for preparing...
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| creator | ILDIKO FRITZSCHE ISTVAN HORVATH PAL IVAN ANNA SZABOLCS JANOS SAGI JANOS NAGY LASZLO OTVOS MARIA PEREDY ISTVAN KOCZKA CSILLA RETHATI ATTILA SZEMZO |
| description | The invention relates to (E)-5-(2-bromovinyl)-uridine and its derivatives of general formula VI, VI wherein R1 stands for a hydrogen atom, C1-8 alkanoyl group, benzoyl group or a benzoyl group substituted in para position either with a C1-4 alkyl group or a halogen atom, and a process for preparing them by brominating 2',3',5'-tri-O-acyl-5-ethyl-uridine of general formula IV, IV wherein R is identical with R1, except where R1 stands for a hydrogen atom, dehydrohalogenating the resulting dibromo compound of general formula V V and optionally deacylating it. The resulting compounds of general formula VI are exhibiting significant potency against Herpes simplex virus species and are of remarkably low acute toxicity. |
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The resulting compounds of general formula VI are exhibiting significant potency against Herpes simplex virus species and are of remarkably low acute toxicity.</description><language>eng</language><subject>CHEMISTRY ; DERIVATIVES THEREOF ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; NUCLEIC ACIDS ; NUCLEOSIDES ; NUCLEOTIDES ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SUGARS</subject><creationdate>1983</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19830407&DB=EPODOC&CC=GB&NR=2106107A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19830407&DB=EPODOC&CC=GB&NR=2106107A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ILDIKO FRITZSCHE</creatorcontrib><creatorcontrib>ISTVAN HORVATH</creatorcontrib><creatorcontrib>PAL IVAN</creatorcontrib><creatorcontrib>ANNA SZABOLCS</creatorcontrib><creatorcontrib>JANOS SAGI</creatorcontrib><creatorcontrib>JANOS NAGY</creatorcontrib><creatorcontrib>LASZLO OTVOS</creatorcontrib><creatorcontrib>MARIA PEREDY</creatorcontrib><creatorcontrib>ISTVAN KOCZKA</creatorcontrib><creatorcontrib>CSILLA RETHATI</creatorcontrib><creatorcontrib>ATTILA SZEMZO</creatorcontrib><title>(E)-5-(2-BROMOVINYL)-URIDINE, ITS DERIVATIVES AND A PROCESS FOR THE PREPARATION THEREOF</title><description>The invention relates to (E)-5-(2-bromovinyl)-uridine and its derivatives of general formula VI, VI wherein R1 stands for a hydrogen atom, C1-8 alkanoyl group, benzoyl group or a benzoyl group substituted in para position either with a C1-4 alkyl group or a halogen atom, and a process for preparing them by brominating 2',3',5'-tri-O-acyl-5-ethyl-uridine of general formula IV, IV wherein R is identical with R1, except where R1 stands for a hydrogen atom, dehydrohalogenating the resulting dibromo compound of general formula V V and optionally deacylating it. 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The resulting compounds of general formula VI are exhibiting significant potency against Herpes simplex virus species and are of remarkably low acute toxicity.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS |
| title | (E)-5-(2-BROMOVINYL)-URIDINE, ITS DERIVATIVES AND A PROCESS FOR THE PREPARATION THEREOF |
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