ANTIGEN PURIFICATION
1,261,673. Antigen purification. FARBENFABRIKEN BAYER A.G. 11 March, 1970 [15 March, 1969], No. 11679/70. Heading A5B. Foot and mouth disease (FMD) virus antigen purified from undesirable proteins is prepared by precipitating the FMD virus antigen from an aqueous solution containing FMD virus antige...
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| creator | HANS BAHNEMANN HORST GEILHAUSEN OTTO WAGNER OTTO ERICH SCHWECKENDIEK |
| description | 1,261,673. Antigen purification. FARBENFABRIKEN BAYER A.G. 11 March, 1970 [15 March, 1969], No. 11679/70. Heading A5B. Foot and mouth disease (FMD) virus antigen purified from undesirable proteins is prepared by precipitating the FMD virus antigen from an aqueous solution containing FMD virus antigen and the undesirable proteins by the addition of polyethylene glycol, and separating the precipitated FMD virus antigen from the supernatant solution. Preferably a polyethylene glycol of molecular weight from 600 to 20,000 is added in the form of an aqueous solution containing from 10 to 70% by weight of polyethylene glycol. The precipitation may be carried out at a pH of 7 to 9 and at a temperature of from 0‹C to 24‹C. The mixture of virus solution and polyethylene glycol preferably contains from 15 to 35% by weight of polyethylene glycol, and may be allowed to stand for 12 to 60 hours after the addition of polyethylene glycol before the precipitated virus antigen is removed from the supernatant solution. The purified FMD virus antigen may be obtained in solid form by crystallisation or lyophilization. The purified FMD virus antigen obtained by the above process usually contains from 0.5 to 5% by weight of the polyethylene glycol. Vaccine compositions consist of or comprise the purified FMD virus antigen in admixture with a solid or liquid diluent or carrier such as an aqueous suspension of aluminium hydroxide or an isotonic buffered solution suitable for parenteral injection. |
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Foot and mouth disease (FMD) virus antigen purified from undesirable proteins is prepared by precipitating the FMD virus antigen from an aqueous solution containing FMD virus antigen and the undesirable proteins by the addition of polyethylene glycol, and separating the precipitated FMD virus antigen from the supernatant solution. Preferably a polyethylene glycol of molecular weight from 600 to 20,000 is added in the form of an aqueous solution containing from 10 to 70% by weight of polyethylene glycol. The precipitation may be carried out at a pH of 7 to 9 and at a temperature of from 0‹C to 24‹C. The mixture of virus solution and polyethylene glycol preferably contains from 15 to 35% by weight of polyethylene glycol, and may be allowed to stand for 12 to 60 hours after the addition of polyethylene glycol before the precipitated virus antigen is removed from the supernatant solution. The purified FMD virus antigen may be obtained in solid form by crystallisation or lyophilization. The purified FMD virus antigen obtained by the above process usually contains from 0.5 to 5% by weight of the polyethylene glycol. Vaccine compositions consist of or comprise the purified FMD virus antigen in admixture with a solid or liquid diluent or carrier such as an aqueous suspension of aluminium hydroxide or an isotonic buffered solution suitable for parenteral injection.</description><language>eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC ; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; TECHNICAL SUBJECTS COVERED BY FORMER USPC ; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS ; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ARTCOLLECTIONS [XRACs] AND DIGESTS ; VINEGAR ; WINE</subject><creationdate>1972</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19720126&DB=EPODOC&CC=GB&NR=1261673A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25546,76297</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19720126&DB=EPODOC&CC=GB&NR=1261673A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HANS BAHNEMANN</creatorcontrib><creatorcontrib>HORST GEILHAUSEN</creatorcontrib><creatorcontrib>OTTO WAGNER</creatorcontrib><creatorcontrib>OTTO ERICH SCHWECKENDIEK</creatorcontrib><title>ANTIGEN PURIFICATION</title><description>1,261,673. Antigen purification. FARBENFABRIKEN BAYER A.G. 11 March, 1970 [15 March, 1969], No. 11679/70. Heading A5B. Foot and mouth disease (FMD) virus antigen purified from undesirable proteins is prepared by precipitating the FMD virus antigen from an aqueous solution containing FMD virus antigen and the undesirable proteins by the addition of polyethylene glycol, and separating the precipitated FMD virus antigen from the supernatant solution. Preferably a polyethylene glycol of molecular weight from 600 to 20,000 is added in the form of an aqueous solution containing from 10 to 70% by weight of polyethylene glycol. The precipitation may be carried out at a pH of 7 to 9 and at a temperature of from 0‹C to 24‹C. The mixture of virus solution and polyethylene glycol preferably contains from 15 to 35% by weight of polyethylene glycol, and may be allowed to stand for 12 to 60 hours after the addition of polyethylene glycol before the precipitated virus antigen is removed from the supernatant solution. The purified FMD virus antigen may be obtained in solid form by crystallisation or lyophilization. The purified FMD virus antigen obtained by the above process usually contains from 0.5 to 5% by weight of the polyethylene glycol. Vaccine compositions consist of or comprise the purified FMD virus antigen in admixture with a solid or liquid diluent or carrier such as an aqueous suspension of aluminium hydroxide or an isotonic buffered solution suitable for parenteral injection.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC</subject><subject>GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>TECHNICAL SUBJECTS COVERED BY FORMER USPC</subject><subject>TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS</subject><subject>TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ARTCOLLECTIONS [XRACs] AND DIGESTS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1972</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZBBx9AvxdHf1UwgIDfJ083R2DPH09-NhYE1LzClO5YXS3Azybq4hzh66qQX58anFBYnJqXmpJfHuToZGZoZm5saOxoRVAAALdR3O</recordid><startdate>19720126</startdate><enddate>19720126</enddate><creator>HANS BAHNEMANN</creator><creator>HORST GEILHAUSEN</creator><creator>OTTO WAGNER</creator><creator>OTTO ERICH SCHWECKENDIEK</creator><scope>EVB</scope></search><sort><creationdate>19720126</creationdate><title>ANTIGEN PURIFICATION</title><author>HANS BAHNEMANN ; HORST GEILHAUSEN ; OTTO WAGNER ; OTTO ERICH SCHWECKENDIEK</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_GB1261673A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1972</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC</topic><topic>GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>TECHNICAL SUBJECTS COVERED BY FORMER USPC</topic><topic>TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS</topic><topic>TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ARTCOLLECTIONS [XRACs] AND DIGESTS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>HANS BAHNEMANN</creatorcontrib><creatorcontrib>HORST GEILHAUSEN</creatorcontrib><creatorcontrib>OTTO WAGNER</creatorcontrib><creatorcontrib>OTTO ERICH SCHWECKENDIEK</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HANS BAHNEMANN</au><au>HORST GEILHAUSEN</au><au>OTTO WAGNER</au><au>OTTO ERICH SCHWECKENDIEK</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>ANTIGEN PURIFICATION</title><date>1972-01-26</date><risdate>1972</risdate><abstract>1,261,673. Antigen purification. FARBENFABRIKEN BAYER A.G. 11 March, 1970 [15 March, 1969], No. 11679/70. Heading A5B. Foot and mouth disease (FMD) virus antigen purified from undesirable proteins is prepared by precipitating the FMD virus antigen from an aqueous solution containing FMD virus antigen and the undesirable proteins by the addition of polyethylene glycol, and separating the precipitated FMD virus antigen from the supernatant solution. Preferably a polyethylene glycol of molecular weight from 600 to 20,000 is added in the form of an aqueous solution containing from 10 to 70% by weight of polyethylene glycol. The precipitation may be carried out at a pH of 7 to 9 and at a temperature of from 0‹C to 24‹C. The mixture of virus solution and polyethylene glycol preferably contains from 15 to 35% by weight of polyethylene glycol, and may be allowed to stand for 12 to 60 hours after the addition of polyethylene glycol before the precipitated virus antigen is removed from the supernatant solution. The purified FMD virus antigen may be obtained in solid form by crystallisation or lyophilization. The purified FMD virus antigen obtained by the above process usually contains from 0.5 to 5% by weight of the polyethylene glycol. Vaccine compositions consist of or comprise the purified FMD virus antigen in admixture with a solid or liquid diluent or carrier such as an aqueous suspension of aluminium hydroxide or an isotonic buffered solution suitable for parenteral injection.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TECHNICAL SUBJECTS COVERED BY FORMER USPC TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ARTCOLLECTIONS [XRACs] AND DIGESTS VINEGAR WINE |
| title | ANTIGEN PURIFICATION |
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