NEW PYRIDOXYLIDENE AMIDOPHOSPHATE DERIVATIVES AND PROCESS FOR THE PRODUCTION OF THE SAME

1,217,773. Pyridoxylidene amidophosphates. YAMANOUCHI PHARMACEUTICAL CO. Ltd. 7 March, 1968, No. 11229/68. Heading C2C. Pyridoxylidene amidophosphates of the formula in which R 1 represents an oxygen atom or a radical of the formula N-R 3 in which R 3 represents a cycloalkyl or alkoxyphenyl radical, or an alkyl radical substituted by one or two radicals selected from alkoxy, aryl, carbamoyl, alkoxycarbonyl and alkylthio radicals, R 2 represents a radical of the formula in which R 4 and R 5 are the same or different and each represents a hydrogen atom or a cycloalkyl, alkoxyphenyl or aralkyl radical, or an alkyl radical substituted by one or two radicals selected from alkoxy, aryl, carbamoyl, alkoxycarbonyl and alkylthio radicals, R 4 and R 5 being capable of forming with the N atom a morpholine ring or a 2-oxopyrrolidine ring with the proviso that R 4 and R 5 cannot at the same time be hydrogen atoms, and M represents an alkali or alkaline earth metal or a cation of the formula They are prepared by reacting a pyridoxylidine phosphate of the formula with an amine of the formula in the presence of a carbodiimide compound. The compounds may be used as pharmaceuticals yielding a coenzyme useful in body metabolism, and may be administered orally, e.g. in the form of tablets or capsules.