COMPOSITION DE PLASMINOGENASE IMMOBILISEE, PROCEDE DE PREPARATION, UTILISATION ET DISPOSITIF COMPRENANT UNE TELLE COMPOSITION
L'invention concerne une composition enzymatique comprenant : au moins une enzyme, dite plasminogénase, de conversion en plasmine de plasminogène d'un milieu plasmatique sanguin comprenant du plasminogène ; - un support solide insoluble en solution aqueuse, ladite plasminogénase étant liée...
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| creator | OUARNE, FRANCOISE REBOUL, GERARD SAUX, Carine |
| description | L'invention concerne une composition enzymatique comprenant : au moins une enzyme, dite plasminogénase, de conversion en plasmine de plasminogène d'un milieu plasmatique sanguin comprenant du plasminogène ; - un support solide insoluble en solution aqueuse, ladite plasminogénase étant liée au support solide et restant liée à ce support au contact d'un milieu plasmatique sanguin, caractérisée en ce que le support solide est formé d'un matériau poreux et présente des dimensions adaptées pour pouvoir être retenu sur un filtre présentant un seuil de coupure inférieur ou égal à 0,22 µm. L'invention concerne également un procédé de préparation d'une telle composition enzymatique, son utilisation et un dispositif (20) pour la préparation d'un milieu plasmatique sanguin ex vivo riche en plasmine stérile et exempt de composition enzymatique.
Disclosed is an enzymatic composition including:-at least one enzyme, termed plasminogenase, for converting, into plasmin, plasminogen from a blood plasma medium including plasminogen;-a solid support that is insoluble in aqueous solution, the solid support having dimensions suitable for being able to be retained on a filter having a cut-off threshold of less than or equal to 0.22 μm. The plasminogenase is bound to the solid support and remains bound to this support on contact with a blood plasma medium. The composition is in the dry state. Also disclosed is a process for preparing such an enzymatic composition, to the use thereof and to a device (20) for preparing a blood plasma medium ex vivo rich in sterile plasmin and free of enzymatic composition. |
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Disclosed is an enzymatic composition including:-at least one enzyme, termed plasminogenase, for converting, into plasmin, plasminogen from a blood plasma medium including plasminogen;-a solid support that is insoluble in aqueous solution, the solid support having dimensions suitable for being able to be retained on a filter having a cut-off threshold of less than or equal to 0.22 μm. The plasminogenase is bound to the solid support and remains bound to this support on contact with a blood plasma medium. The composition is in the dry state. Also disclosed is a process for preparing such an enzymatic composition, to the use thereof and to a device (20) for preparing a blood plasma medium ex vivo rich in sterile plasmin and free of enzymatic composition.</description><language>fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200207&DB=EPODOC&CC=FR&NR=3035120B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200207&DB=EPODOC&CC=FR&NR=3035120B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>OUARNE, FRANCOISE</creatorcontrib><creatorcontrib>REBOUL, GERARD</creatorcontrib><creatorcontrib>SAUX, Carine</creatorcontrib><title>COMPOSITION DE PLASMINOGENASE IMMOBILISEE, PROCEDE DE PREPARATION, UTILISATION ET DISPOSITIF COMPRENANT UNE TELLE COMPOSITION</title><description>L'invention concerne une composition enzymatique comprenant : au moins une enzyme, dite plasminogénase, de conversion en plasmine de plasminogène d'un milieu plasmatique sanguin comprenant du plasminogène ; - un support solide insoluble en solution aqueuse, ladite plasminogénase étant liée au support solide et restant liée à ce support au contact d'un milieu plasmatique sanguin, caractérisée en ce que le support solide est formé d'un matériau poreux et présente des dimensions adaptées pour pouvoir être retenu sur un filtre présentant un seuil de coupure inférieur ou égal à 0,22 µm. L'invention concerne également un procédé de préparation d'une telle composition enzymatique, son utilisation et un dispositif (20) pour la préparation d'un milieu plasmatique sanguin ex vivo riche en plasmine stérile et exempt de composition enzymatique.
Disclosed is an enzymatic composition including:-at least one enzyme, termed plasminogenase, for converting, into plasmin, plasminogen from a blood plasma medium including plasminogen;-a solid support that is insoluble in aqueous solution, the solid support having dimensions suitable for being able to be retained on a filter having a cut-off threshold of less than or equal to 0.22 μm. The plasminogenase is bound to the solid support and remains bound to this support on contact with a blood plasma medium. The composition is in the dry state. Also disclosed is a process for preparing such an enzymatic composition, to the use thereof and to a device (20) for preparing a blood plasma medium ex vivo rich in sterile plasmin and free of enzymatic composition.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjU0KwjAUhLtxIeod3gEqtAYPkKYv-iB_JOm6lBJXooW69e426sKlq2Hgm2_WxVNY7WygSNZAi-AUD5qMPaHhAYG0tg0pCoglOG8FLkzGPDrueV6V0MVMvAtghJbCxyghy_1iMhE6gxBRKYSfx22xugzXOe2-uSlAYhTnfZrufZqnYUy39OilZxU71oeqqdkfyAuSYDtv</recordid><startdate>20200207</startdate><enddate>20200207</enddate><creator>OUARNE, FRANCOISE</creator><creator>REBOUL, GERARD</creator><creator>SAUX, Carine</creator><scope>EVB</scope></search><sort><creationdate>20200207</creationdate><title>COMPOSITION DE PLASMINOGENASE IMMOBILISEE, PROCEDE DE PREPARATION, UTILISATION ET DISPOSITIF COMPRENANT UNE TELLE COMPOSITION</title><author>OUARNE, FRANCOISE ; REBOUL, GERARD ; SAUX, Carine</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_FR3035120B13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>fre</language><creationdate>2020</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>OUARNE, FRANCOISE</creatorcontrib><creatorcontrib>REBOUL, GERARD</creatorcontrib><creatorcontrib>SAUX, Carine</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>OUARNE, FRANCOISE</au><au>REBOUL, GERARD</au><au>SAUX, Carine</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>COMPOSITION DE PLASMINOGENASE IMMOBILISEE, PROCEDE DE PREPARATION, UTILISATION ET DISPOSITIF COMPRENANT UNE TELLE COMPOSITION</title><date>2020-02-07</date><risdate>2020</risdate><abstract>L'invention concerne une composition enzymatique comprenant : au moins une enzyme, dite plasminogénase, de conversion en plasmine de plasminogène d'un milieu plasmatique sanguin comprenant du plasminogène ; - un support solide insoluble en solution aqueuse, ladite plasminogénase étant liée au support solide et restant liée à ce support au contact d'un milieu plasmatique sanguin, caractérisée en ce que le support solide est formé d'un matériau poreux et présente des dimensions adaptées pour pouvoir être retenu sur un filtre présentant un seuil de coupure inférieur ou égal à 0,22 µm. L'invention concerne également un procédé de préparation d'une telle composition enzymatique, son utilisation et un dispositif (20) pour la préparation d'un milieu plasmatique sanguin ex vivo riche en plasmine stérile et exempt de composition enzymatique.
Disclosed is an enzymatic composition including:-at least one enzyme, termed plasminogenase, for converting, into plasmin, plasminogen from a blood plasma medium including plasminogen;-a solid support that is insoluble in aqueous solution, the solid support having dimensions suitable for being able to be retained on a filter having a cut-off threshold of less than or equal to 0.22 μm. The plasminogenase is bound to the solid support and remains bound to this support on contact with a blood plasma medium. The composition is in the dry state. Also disclosed is a process for preparing such an enzymatic composition, to the use thereof and to a device (20) for preparing a blood plasma medium ex vivo rich in sterile plasmin and free of enzymatic composition.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | COMPOSITION DE PLASMINOGENASE IMMOBILISEE, PROCEDE DE PREPARATION, UTILISATION ET DISPOSITIF COMPRENANT UNE TELLE COMPOSITION |
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