DERIVES DE LA QUINOLEINE, LEUR PROCEDE DE PREPARATION ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT

LA PRESENTE INVENTION EST RELATIVE A DES DERIVES DE QUINOLEINE, A LEUR PROCEDE DE PREPARATION ET A DES COMPOSITIONS PHARMACEUTIQUES LES CONTENANT.CES DERIVES CORRESPONDENT A LA FORMULE GENERALE I(CF DESSIN DANS BOPI)DANS LAQUELLE :X EST UN ATOME D'HYDROGENE, D'HALOGENE OU UN GROUPE ALCOXY INFERIEUR;N EST EGAL A 1, 2 OU 3;R REPRESENTE UN ATOME D'HYDROGENE ETR REPRESENTE UN GROUPE HYDROXY-ALCOYLE INFERIEUR OU UN GROUPE ALCOXY (INFERIEUR)-ALCOYLE INFERIEUR OU UN GROUPE DE FORMULE GENERALE IV(CF DESSIN DANS BOPI) The invention relates to new quinoline derivatives of the general Formula I (I) (wherein X stands for hydrogen, halogen or lower alkoxy; n is an integer of 1, 2 or 3; R1 represents hydrogen and R2 represents hydroxy-lower alkyl or lower alkoxy-lower alkyl or a group of the general formula IV, (IV) wherein Z stands for -O-, -S-, -NH- or -N(lower alkyl)-; the dotted lines represent optional bonds; and m is 0 or 1; or R1 and R2 together with the adjacent nitrogen atom, they are attached to, form a 5- or 6-membered heterocyclic group which may optionally contain a further oxygen, nitrogen or sulfur heteroatom and may be optionally substituted), and pharmaceutically acceptable acid addition salts thereof. The new compounds of the present invention exhibit radiosensitizing effect, make hypoxial cells highly sensitive towards radiation and may be used in radiation therapy.