PARTICULES D'HYDROGEL SPHERIQUES, A EFFET DE CONTRASTE, A BASE DE POLYMERES ET DE COPOLYMERES D'ACRYLATES ET DE METHACRYLATES, ET PROCEDE POUR LEUR PREPARATION
The invention pertains to X-ray contrast spherical hydrogel particles based on polymers and copolymers of acrylates and methacrylates and to a method of their preparation. The subject of this invention are X-ray contrast spherical hydrogel particles based on polymers and copolymers of acrylates and...
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| creator | DANIEL HORAK, MARIE METALOVA, FRANTISEK SVEC, JAROSLAV DROBNIK, JAROSLAV KALAL, MICHAIL KUZIN, ARNOLD ADAMJAN, JURIJ MOJSEJEV ET KLARA GUMARGALIJEVA |
| description | The invention pertains to X-ray contrast spherical hydrogel particles based on polymers and copolymers of acrylates and methacrylates and to a method of their preparation. The subject of this invention are X-ray contrast spherical hydrogel particles based on polymers and copolymers of acrylates and methacrylates characterized by the particles of spherical form with diameter 0.2 to 2 mm, which strongly swell in water and contain a derivative of amino-triiodobenzoic acid of general formula I, I where R1,R2 is hydrogen, acyl group with 1 to 3 carbon atoms or alkyl with 1 to 10 carbon atoms and X is halogen, -OH or -NH(CH2)nNH2, where n=1-6, covalently bonded to the polymer skeleton. A method for preparation of X-ray contrast hydrogel particles according to the invention in which hydrogel particles, containing hydroxyl or epoxide groups localized on side chains of the polymer skeleton, are allowed to swell in an excess of a solvent chosen from the group comprising dioxane, dimethylacetamide, dimethylformamide, tetrahydrofuran and dimethylsulfoxide, which contains the dissolved derivative of amino-triiodobenzoic acid of the general formula I, optionally together with a compound reacting with hydrogen halogenide formed, which is selected, for example, from the group comprising tertiary amines, the dispersion is heated to 100 DEG C. at utmost and allowed to react for 150 hours at utmost, the solid phase is separated and freed of soluble substances by washing. The procedure according to the invention provides spherical hydrogels with X-ray contrast properties without changing their other properties substantial for application in medical practice. |
| format | Patent |
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The subject of this invention are X-ray contrast spherical hydrogel particles based on polymers and copolymers of acrylates and methacrylates characterized by the particles of spherical form with diameter 0.2 to 2 mm, which strongly swell in water and contain a derivative of amino-triiodobenzoic acid of general formula I, I where R1,R2 is hydrogen, acyl group with 1 to 3 carbon atoms or alkyl with 1 to 10 carbon atoms and X is halogen, -OH or -NH(CH2)nNH2, where n=1-6, covalently bonded to the polymer skeleton. A method for preparation of X-ray contrast hydrogel particles according to the invention in which hydrogel particles, containing hydroxyl or epoxide groups localized on side chains of the polymer skeleton, are allowed to swell in an excess of a solvent chosen from the group comprising dioxane, dimethylacetamide, dimethylformamide, tetrahydrofuran and dimethylsulfoxide, which contains the dissolved derivative of amino-triiodobenzoic acid of the general formula I, optionally together with a compound reacting with hydrogen halogenide formed, which is selected, for example, from the group comprising tertiary amines, the dispersion is heated to 100 DEG C. at utmost and allowed to react for 150 hours at utmost, the solid phase is separated and freed of soluble substances by washing. The procedure according to the invention provides spherical hydrogels with X-ray contrast properties without changing their other properties substantial for application in medical practice.</description><edition>4</edition><language>fre</language><subject>CHEMISTRY ; COMPOSITIONS BASED THEREON ; DIAGNOSIS ; HUMAN NECESSITIES ; HYGIENE ; IDENTIFICATION ; MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC MACROMOLECULAR COMPOUNDS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SURGERY ; THEIR PREPARATION OR CHEMICAL WORKING-UP</subject><creationdate>1989</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19890407&DB=EPODOC&CC=FR&NR=2574297B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25546,76297</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19890407&DB=EPODOC&CC=FR&NR=2574297B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>DANIEL HORAK, MARIE METALOVA, FRANTISEK SVEC, JAROSLAV DROBNIK, JAROSLAV KALAL, MICHAIL KUZIN, ARNOLD ADAMJAN, JURIJ MOJSEJEV ET KLARA GUMARGALIJEVA</creatorcontrib><title>PARTICULES D'HYDROGEL SPHERIQUES, A EFFET DE CONTRASTE, A BASE DE POLYMERES ET DE COPOLYMERES D'ACRYLATES ET DE METHACRYLATES, ET PROCEDE POUR LEUR PREPARATION</title><description>The invention pertains to X-ray contrast spherical hydrogel particles based on polymers and copolymers of acrylates and methacrylates and to a method of their preparation. The subject of this invention are X-ray contrast spherical hydrogel particles based on polymers and copolymers of acrylates and methacrylates characterized by the particles of spherical form with diameter 0.2 to 2 mm, which strongly swell in water and contain a derivative of amino-triiodobenzoic acid of general formula I, I where R1,R2 is hydrogen, acyl group with 1 to 3 carbon atoms or alkyl with 1 to 10 carbon atoms and X is halogen, -OH or -NH(CH2)nNH2, where n=1-6, covalently bonded to the polymer skeleton. A method for preparation of X-ray contrast hydrogel particles according to the invention in which hydrogel particles, containing hydroxyl or epoxide groups localized on side chains of the polymer skeleton, are allowed to swell in an excess of a solvent chosen from the group comprising dioxane, dimethylacetamide, dimethylformamide, tetrahydrofuran and dimethylsulfoxide, which contains the dissolved derivative of amino-triiodobenzoic acid of the general formula I, optionally together with a compound reacting with hydrogen halogenide formed, which is selected, for example, from the group comprising tertiary amines, the dispersion is heated to 100 DEG C. at utmost and allowed to react for 150 hours at utmost, the solid phase is separated and freed of soluble substances by washing. 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The subject of this invention are X-ray contrast spherical hydrogel particles based on polymers and copolymers of acrylates and methacrylates characterized by the particles of spherical form with diameter 0.2 to 2 mm, which strongly swell in water and contain a derivative of amino-triiodobenzoic acid of general formula I, I where R1,R2 is hydrogen, acyl group with 1 to 3 carbon atoms or alkyl with 1 to 10 carbon atoms and X is halogen, -OH or -NH(CH2)nNH2, where n=1-6, covalently bonded to the polymer skeleton. A method for preparation of X-ray contrast hydrogel particles according to the invention in which hydrogel particles, containing hydroxyl or epoxide groups localized on side chains of the polymer skeleton, are allowed to swell in an excess of a solvent chosen from the group comprising dioxane, dimethylacetamide, dimethylformamide, tetrahydrofuran and dimethylsulfoxide, which contains the dissolved derivative of amino-triiodobenzoic acid of the general formula I, optionally together with a compound reacting with hydrogen halogenide formed, which is selected, for example, from the group comprising tertiary amines, the dispersion is heated to 100 DEG C. at utmost and allowed to react for 150 hours at utmost, the solid phase is separated and freed of soluble substances by washing. The procedure according to the invention provides spherical hydrogels with X-ray contrast properties without changing their other properties substantial for application in medical practice.</abstract><edition>4</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY COMPOSITIONS BASED THEREON DIAGNOSIS HUMAN NECESSITIES HYGIENE IDENTIFICATION MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC MACROMOLECULAR COMPOUNDS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SURGERY THEIR PREPARATION OR CHEMICAL WORKING-UP |
| title | PARTICULES D'HYDROGEL SPHERIQUES, A EFFET DE CONTRASTE, A BASE DE POLYMERES ET DE COPOLYMERES D'ACRYLATES ET DE METHACRYLATES, ET PROCEDE POUR LEUR PREPARATION |
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