AMINOCYCLITOLS ANTIBIOTIQUES ET LEURS PROCEDES DE PREPARATION
1529376 Aminocyclitol antibiotics STERLING DRUG Inc 9 Feb 1976 [18 Feb 1975 22 Sept 1975] 04973/76 Heading C2C Novel aminocyclitol antibiotics of the general Formula I wherein R 1 , R 3 and R 8 are hydrogen, or one of R 1 , R 3 and R 8 is H 2 NCH 2 (CH 2 ) n CHOHCO-, wherein n is 0 or 1, and the oth...
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Patent |
| Sprache: | fre |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | SOL JACOB DAUM ET ROBERT LA GRONE CLARKE |
| description | 1529376 Aminocyclitol antibiotics STERLING DRUG Inc 9 Feb 1976 [18 Feb 1975 22 Sept 1975] 04973/76 Heading C2C Novel aminocyclitol antibiotics of the general Formula I wherein R 1 , R 3 and R 8 are hydrogen, or one of R 1 , R 3 and R 8 is H 2 NCH 2 (CH 2 ) n CHOHCO-, wherein n is 0 or 1, and the others are hydrogen; R 2 is H or OH; R 5 is hydrogen, hydroxy or halogen, except that when R 2 is hydrogen, R 5 is not hydroxy cis to the amino groups at the 1- and 3- positions; and R 6 and R 7 are each hydrogen or methyl, and acid addition salts thereof are prepared (a) when R 1 ,R 4 and R 8 are each hydrogen, by culturing a nutrient medium containing carbohydrates, a source of assimilable nitrogen, essential salts and a corresponding aminocyclitol of the general formula wherein R 1 , R 2 , R 3 and R 5 are as defined above, except that R 1 and R 3 may also form a single bond between the nitrogen atoms to which they are attached, in the presence of Micromonospora purpurea ATCC 31,119, and isolating the desired product from the medium; (b) when R 1 , R 3 and R 8 are each hydrogen and R 5 is as defined above with the exception of halogen, by culturing a nutrient medium containing carbohydrates, a source of assimilable nitrogen, essential salts and a cyclitol of the general formula wherein R is hydrogen or acetyl, R1 3 is oxo or hydroxy and R1 2 and R1 5 are each hydrogen or OR, in the presence of Micromonospora purpurea ATCC 31,164; (c) when R 1 , R 3 and R 8 are each hydrogen and R 5 is as defined above with the exception of halogen, by culturing a nutrient medium containing carbohydrates, a source of assimilable nitrogen, essential salts and an aminoclitol of the general formula wherein R1 2 and R1 5 correspond to R 2 and R 5 and R1 1 is amino or hydroxy, in the presence of Micromonospora purpurea 31,164; and (d) when one of R 1 , R 3 and R 8 is by reacting the product of (a), (b) or (c) with an N-hydroxysuccinimide ester of the general formula followed by hydrogenolysis of the resulting N- benzylorycarbonyl derivative with hydrogen and a catalyst; followed optionally by salification of the product. dl-Deoxyinosose is prepared by microbiological oxidation of dl-viboquercitol with Acetobacter suboxydans. dl - 2,3,4,6 - Tetrahydroxy - cyclohexanone- (2,4,6-cis) is prepared by reducing dl-epiinosose with hydrogen and PtO 2 and oxidizing the resulting di-epi-quercitol with Acetobacter suboxydans, 2,4,5-Tri-hydroxycyclohexanone(2,4-cis) is prepared by treating 4-cycloh |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_FR2301265A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>FR2301265A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_FR2301265A13</originalsourceid><addsrcrecordid>eNrjZLB19PX083eOdPbxDPH3CVZw9AvxdPL0D_EMDHUNVnANUfBxDQ0KVggI8nd2dQGKuLgC2a4BjkGOIZ7-fjwMrGmJOcWpvFCam0HBzTXE2UM3tSA_PrW4IDE5NS-1JN4tyMjYwNDIzNTR0JgIJQAQJCnK</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>AMINOCYCLITOLS ANTIBIOTIQUES ET LEURS PROCEDES DE PREPARATION</title><source>esp@cenet</source><creator>SOL JACOB DAUM ET ROBERT LA GRONE CLARKE</creator><creatorcontrib>SOL JACOB DAUM ET ROBERT LA GRONE CLARKE</creatorcontrib><description>1529376 Aminocyclitol antibiotics STERLING DRUG Inc 9 Feb 1976 [18 Feb 1975 22 Sept 1975] 04973/76 Heading C2C Novel aminocyclitol antibiotics of the general Formula I wherein R 1 , R 3 and R 8 are hydrogen, or one of R 1 , R 3 and R 8 is H 2 NCH 2 (CH 2 ) n CHOHCO-, wherein n is 0 or 1, and the others are hydrogen; R 2 is H or OH; R 5 is hydrogen, hydroxy or halogen, except that when R 2 is hydrogen, R 5 is not hydroxy cis to the amino groups at the 1- and 3- positions; and R 6 and R 7 are each hydrogen or methyl, and acid addition salts thereof are prepared (a) when R 1 ,R 4 and R 8 are each hydrogen, by culturing a nutrient medium containing carbohydrates, a source of assimilable nitrogen, essential salts and a corresponding aminocyclitol of the general formula wherein R 1 , R 2 , R 3 and R 5 are as defined above, except that R 1 and R 3 may also form a single bond between the nitrogen atoms to which they are attached, in the presence of Micromonospora purpurea ATCC 31,119, and isolating the desired product from the medium; (b) when R 1 , R 3 and R 8 are each hydrogen and R 5 is as defined above with the exception of halogen, by culturing a nutrient medium containing carbohydrates, a source of assimilable nitrogen, essential salts and a cyclitol of the general formula wherein R is hydrogen or acetyl, R1 3 is oxo or hydroxy and R1 2 and R1 5 are each hydrogen or OR, in the presence of Micromonospora purpurea ATCC 31,164; (c) when R 1 , R 3 and R 8 are each hydrogen and R 5 is as defined above with the exception of halogen, by culturing a nutrient medium containing carbohydrates, a source of assimilable nitrogen, essential salts and an aminoclitol of the general formula wherein R1 2 and R1 5 correspond to R 2 and R 5 and R1 1 is amino or hydroxy, in the presence of Micromonospora purpurea 31,164; and (d) when one of R 1 , R 3 and R 8 is by reacting the product of (a), (b) or (c) with an N-hydroxysuccinimide ester of the general formula followed by hydrogenolysis of the resulting N- benzylorycarbonyl derivative with hydrogen and a catalyst; followed optionally by salification of the product. dl-Deoxyinosose is prepared by microbiological oxidation of dl-viboquercitol with Acetobacter suboxydans. dl - 2,3,4,6 - Tetrahydroxy - cyclohexanone- (2,4,6-cis) is prepared by reducing dl-epiinosose with hydrogen and PtO 2 and oxidizing the resulting di-epi-quercitol with Acetobacter suboxydans, 2,4,5-Tri-hydroxycyclohexanone(2,4-cis) is prepared by treating 4-cyclohexene-1α,2#-diol with 3-chloroperbenzoic acid and heating the resulting 4,5-epoxycyclohexane-1α,2#-diol with BF 3 etherate. 2,5-Dideoxy-5-iodostreptamine is prepared by treating 2-deoxy-1,6 : 3,4-dicarbonylstreptamine with methanesulphonyl chloride, treating the resulting 5-O-methanesulphonyl derivative with Na1, refluxing the resulting 5-deoxy- 5-iodo derivative with HCl, treating the resulting 2,5-dideoxy-5-iodostreptamine dihydrochloride with acetic anhydride and sodium acetate and hydrolysing the resulting N,N1-diacetyl-2,5- dideoxy-5-iodo-streptamine with aqueous HCl. 2,5-Dideoxy-5-fluorostreptamine is prepared by heating 2-deoxy-5-O-methanesulphonyl-1,6 : 3,4-dicarbonylstreptamine with HCl, reacting the resulting 2-deoxy-5-O-methanesulphonylstreptamine dihydrochloride with aqueous NaOH and then benzyl chloroformate, treating the resulting N,N1- di - carbobenzoxy - 2 -deoxy - 5-O- methanesulphonylstreptamine with KF and hydrolysing the resulting N,N1-dicarbobenzoxy- 2,5-dideoxy-5-fluorostreptamine with aqueous mineral acid. Pharmaceutical compositions having antibacterial activity comprise, as active ingredient, an aminocyclitol antibiotic (I) or an acid addition salt thereof, together with a pharmaceutical carrier.</description><language>fre</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; APPARATUS THEREFOR ; BEER ; BIOCHEMISTRY ; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY ; CHEMISTRY ; DERIVATIVES THEREOF ; ENZYMOLOGY ; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE ; GENERAL METHODS OF ORGANIC CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; MICROBIOLOGY ; MUTATION OR GENETIC ENGINEERING ; NUCLEIC ACIDS ; NUCLEOSIDES ; NUCLEOTIDES ; ORGANIC CHEMISTRY ; PERFORMING OPERATIONS ; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL ; SPIRITS ; SUGARS ; THEIR RELEVANT APPARATUS ; TRANSPORTING ; VINEGAR ; WINE</subject><creationdate>1976</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19760917&DB=EPODOC&CC=FR&NR=2301265A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19760917&DB=EPODOC&CC=FR&NR=2301265A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SOL JACOB DAUM ET ROBERT LA GRONE CLARKE</creatorcontrib><title>AMINOCYCLITOLS ANTIBIOTIQUES ET LEURS PROCEDES DE PREPARATION</title><description>1529376 Aminocyclitol antibiotics STERLING DRUG Inc 9 Feb 1976 [18 Feb 1975 22 Sept 1975] 04973/76 Heading C2C Novel aminocyclitol antibiotics of the general Formula I wherein R 1 , R 3 and R 8 are hydrogen, or one of R 1 , R 3 and R 8 is H 2 NCH 2 (CH 2 ) n CHOHCO-, wherein n is 0 or 1, and the others are hydrogen; R 2 is H or OH; R 5 is hydrogen, hydroxy or halogen, except that when R 2 is hydrogen, R 5 is not hydroxy cis to the amino groups at the 1- and 3- positions; and R 6 and R 7 are each hydrogen or methyl, and acid addition salts thereof are prepared (a) when R 1 ,R 4 and R 8 are each hydrogen, by culturing a nutrient medium containing carbohydrates, a source of assimilable nitrogen, essential salts and a corresponding aminocyclitol of the general formula wherein R 1 , R 2 , R 3 and R 5 are as defined above, except that R 1 and R 3 may also form a single bond between the nitrogen atoms to which they are attached, in the presence of Micromonospora purpurea ATCC 31,119, and isolating the desired product from the medium; (b) when R 1 , R 3 and R 8 are each hydrogen and R 5 is as defined above with the exception of halogen, by culturing a nutrient medium containing carbohydrates, a source of assimilable nitrogen, essential salts and a cyclitol of the general formula wherein R is hydrogen or acetyl, R1 3 is oxo or hydroxy and R1 2 and R1 5 are each hydrogen or OR, in the presence of Micromonospora purpurea ATCC 31,164; (c) when R 1 , R 3 and R 8 are each hydrogen and R 5 is as defined above with the exception of halogen, by culturing a nutrient medium containing carbohydrates, a source of assimilable nitrogen, essential salts and an aminoclitol of the general formula wherein R1 2 and R1 5 correspond to R 2 and R 5 and R1 1 is amino or hydroxy, in the presence of Micromonospora purpurea 31,164; and (d) when one of R 1 , R 3 and R 8 is by reacting the product of (a), (b) or (c) with an N-hydroxysuccinimide ester of the general formula followed by hydrogenolysis of the resulting N- benzylorycarbonyl derivative with hydrogen and a catalyst; followed optionally by salification of the product. dl-Deoxyinosose is prepared by microbiological oxidation of dl-viboquercitol with Acetobacter suboxydans. dl - 2,3,4,6 - Tetrahydroxy - cyclohexanone- (2,4,6-cis) is prepared by reducing dl-epiinosose with hydrogen and PtO 2 and oxidizing the resulting di-epi-quercitol with Acetobacter suboxydans, 2,4,5-Tri-hydroxycyclohexanone(2,4-cis) is prepared by treating 4-cyclohexene-1α,2#-diol with 3-chloroperbenzoic acid and heating the resulting 4,5-epoxycyclohexane-1α,2#-diol with BF 3 etherate. 2,5-Dideoxy-5-iodostreptamine is prepared by treating 2-deoxy-1,6 : 3,4-dicarbonylstreptamine with methanesulphonyl chloride, treating the resulting 5-O-methanesulphonyl derivative with Na1, refluxing the resulting 5-deoxy- 5-iodo derivative with HCl, treating the resulting 2,5-dideoxy-5-iodostreptamine dihydrochloride with acetic anhydride and sodium acetate and hydrolysing the resulting N,N1-diacetyl-2,5- dideoxy-5-iodo-streptamine with aqueous HCl. 2,5-Dideoxy-5-fluorostreptamine is prepared by heating 2-deoxy-5-O-methanesulphonyl-1,6 : 3,4-dicarbonylstreptamine with HCl, reacting the resulting 2-deoxy-5-O-methanesulphonylstreptamine dihydrochloride with aqueous NaOH and then benzyl chloroformate, treating the resulting N,N1- di - carbobenzoxy - 2 -deoxy - 5-O- methanesulphonylstreptamine with KF and hydrolysing the resulting N,N1-dicarbobenzoxy- 2,5-dideoxy-5-fluorostreptamine with aqueous mineral acid. Pharmaceutical compositions having antibacterial activity comprise, as active ingredient, an aminocyclitol antibiotic (I) or an acid addition salt thereof, together with a pharmaceutical carrier.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>APPARATUS THEREFOR</subject><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>DERIVATIVES THEREOF</subject><subject>ENZYMOLOGY</subject><subject>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</subject><subject>GENERAL METHODS OF ORGANIC CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>NUCLEIC ACIDS</subject><subject>NUCLEOSIDES</subject><subject>NUCLEOTIDES</subject><subject>ORGANIC CHEMISTRY</subject><subject>PERFORMING OPERATIONS</subject><subject>PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL</subject><subject>SPIRITS</subject><subject>SUGARS</subject><subject>THEIR RELEVANT APPARATUS</subject><subject>TRANSPORTING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1976</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLB19PX083eOdPbxDPH3CVZw9AvxdPL0D_EMDHUNVnANUfBxDQ0KVggI8nd2dQGKuLgC2a4BjkGOIZ7-fjwMrGmJOcWpvFCam0HBzTXE2UM3tSA_PrW4IDE5NS-1JN4tyMjYwNDIzNTR0JgIJQAQJCnK</recordid><startdate>19760917</startdate><enddate>19760917</enddate><creator>SOL JACOB DAUM ET ROBERT LA GRONE CLARKE</creator><scope>EVB</scope></search><sort><creationdate>19760917</creationdate><title>AMINOCYCLITOLS ANTIBIOTIQUES ET LEURS PROCEDES DE PREPARATION</title><author>SOL JACOB DAUM ET ROBERT LA GRONE CLARKE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_FR2301265A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>fre</language><creationdate>1976</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>APPARATUS THEREFOR</topic><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>DERIVATIVES THEREOF</topic><topic>ENZYMOLOGY</topic><topic>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</topic><topic>GENERAL METHODS OF ORGANIC CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>NUCLEIC ACIDS</topic><topic>NUCLEOSIDES</topic><topic>NUCLEOTIDES</topic><topic>ORGANIC CHEMISTRY</topic><topic>PERFORMING OPERATIONS</topic><topic>PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL</topic><topic>SPIRITS</topic><topic>SUGARS</topic><topic>THEIR RELEVANT APPARATUS</topic><topic>TRANSPORTING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>SOL JACOB DAUM ET ROBERT LA GRONE CLARKE</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SOL JACOB DAUM ET ROBERT LA GRONE CLARKE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>AMINOCYCLITOLS ANTIBIOTIQUES ET LEURS PROCEDES DE PREPARATION</title><date>1976-09-17</date><risdate>1976</risdate><abstract>1529376 Aminocyclitol antibiotics STERLING DRUG Inc 9 Feb 1976 [18 Feb 1975 22 Sept 1975] 04973/76 Heading C2C Novel aminocyclitol antibiotics of the general Formula I wherein R 1 , R 3 and R 8 are hydrogen, or one of R 1 , R 3 and R 8 is H 2 NCH 2 (CH 2 ) n CHOHCO-, wherein n is 0 or 1, and the others are hydrogen; R 2 is H or OH; R 5 is hydrogen, hydroxy or halogen, except that when R 2 is hydrogen, R 5 is not hydroxy cis to the amino groups at the 1- and 3- positions; and R 6 and R 7 are each hydrogen or methyl, and acid addition salts thereof are prepared (a) when R 1 ,R 4 and R 8 are each hydrogen, by culturing a nutrient medium containing carbohydrates, a source of assimilable nitrogen, essential salts and a corresponding aminocyclitol of the general formula wherein R 1 , R 2 , R 3 and R 5 are as defined above, except that R 1 and R 3 may also form a single bond between the nitrogen atoms to which they are attached, in the presence of Micromonospora purpurea ATCC 31,119, and isolating the desired product from the medium; (b) when R 1 , R 3 and R 8 are each hydrogen and R 5 is as defined above with the exception of halogen, by culturing a nutrient medium containing carbohydrates, a source of assimilable nitrogen, essential salts and a cyclitol of the general formula wherein R is hydrogen or acetyl, R1 3 is oxo or hydroxy and R1 2 and R1 5 are each hydrogen or OR, in the presence of Micromonospora purpurea ATCC 31,164; (c) when R 1 , R 3 and R 8 are each hydrogen and R 5 is as defined above with the exception of halogen, by culturing a nutrient medium containing carbohydrates, a source of assimilable nitrogen, essential salts and an aminoclitol of the general formula wherein R1 2 and R1 5 correspond to R 2 and R 5 and R1 1 is amino or hydroxy, in the presence of Micromonospora purpurea 31,164; and (d) when one of R 1 , R 3 and R 8 is by reacting the product of (a), (b) or (c) with an N-hydroxysuccinimide ester of the general formula followed by hydrogenolysis of the resulting N- benzylorycarbonyl derivative with hydrogen and a catalyst; followed optionally by salification of the product. dl-Deoxyinosose is prepared by microbiological oxidation of dl-viboquercitol with Acetobacter suboxydans. dl - 2,3,4,6 - Tetrahydroxy - cyclohexanone- (2,4,6-cis) is prepared by reducing dl-epiinosose with hydrogen and PtO 2 and oxidizing the resulting di-epi-quercitol with Acetobacter suboxydans, 2,4,5-Tri-hydroxycyclohexanone(2,4-cis) is prepared by treating 4-cyclohexene-1α,2#-diol with 3-chloroperbenzoic acid and heating the resulting 4,5-epoxycyclohexane-1α,2#-diol with BF 3 etherate. 2,5-Dideoxy-5-iodostreptamine is prepared by treating 2-deoxy-1,6 : 3,4-dicarbonylstreptamine with methanesulphonyl chloride, treating the resulting 5-O-methanesulphonyl derivative with Na1, refluxing the resulting 5-deoxy- 5-iodo derivative with HCl, treating the resulting 2,5-dideoxy-5-iodostreptamine dihydrochloride with acetic anhydride and sodium acetate and hydrolysing the resulting N,N1-diacetyl-2,5- dideoxy-5-iodo-streptamine with aqueous HCl. 2,5-Dideoxy-5-fluorostreptamine is prepared by heating 2-deoxy-5-O-methanesulphonyl-1,6 : 3,4-dicarbonylstreptamine with HCl, reacting the resulting 2-deoxy-5-O-methanesulphonylstreptamine dihydrochloride with aqueous NaOH and then benzyl chloroformate, treating the resulting N,N1- di - carbobenzoxy - 2 -deoxy - 5-O- methanesulphonylstreptamine with KF and hydrolysing the resulting N,N1-dicarbobenzoxy- 2,5-dideoxy-5-fluorostreptamine with aqueous mineral acid. Pharmaceutical compositions having antibacterial activity comprise, as active ingredient, an aminocyclitol antibiotic (I) or an acid addition salt thereof, together with a pharmaceutical carrier.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | fre |
| recordid | cdi_epo_espacenet_FR2301265A1 |
| source | esp@cenet |
| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS APPARATUS THEREFOR BEER BIOCHEMISTRY CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY DERIVATIVES THEREOF ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE GENERAL METHODS OF ORGANIC CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL SPIRITS SUGARS THEIR RELEVANT APPARATUS TRANSPORTING VINEGAR WINE |
| title | AMINOCYCLITOLS ANTIBIOTIQUES ET LEURS PROCEDES DE PREPARATION |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T13%3A05%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=SOL%20JACOB%20DAUM%20ET%20ROBERT%20LA%20GRONE%20CLARKE&rft.date=1976-09-17&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EFR2301265A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |