Nouveau procédé de préparation de l'oxytétracycline, par fermentation à l'aide d'une nouvelle espèce de streptomyces
Oxytetracyline is produced by cultivating Streptomyces henetus (I.M.I. 109532; I.M. 3872) nor. spec. under aerobic conditions in a nutrient medium. A typical medium contains starch, corn steep liquor, calcium carbonate, casein, (NH4)2SO4, K2HPO4 and water. The pH of cultivation is 6.1 to 8.0 and tem...
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| description | Oxytetracyline is produced by cultivating Streptomyces henetus (I.M.I. 109532; I.M. 3872) nor. spec. under aerobic conditions in a nutrient medium. A typical medium contains starch, corn steep liquor, calcium carbonate, casein, (NH4)2SO4, K2HPO4 and water. The pH of cultivation is 6.1 to 8.0 and temperature is 24 DEG to 37 DEG C. The broth is acidified to pH 2 to 2.5, clarified, treated with oxalic acid, clarified, adjusted to pH 8-8.5, extracted with a mixture of tricresol and CCl4, the organic phase separated, treated with aqueous HCl and acetone and oxytetracycline recovered from the aqueous phase at pH 7.0. The oxytetracycline may be converted into a salt with a mineral or organic acid, e.g. citric or tartaric acid. Other methods of isolation and purification are (a) solvent extraction with, e.g. butanol, (b) adsorption on, e.g. activated carbon, (c) precipitation with substances capable of forming insoluble derivatives, e.g. N,N1-malonylurea and sulphates. |
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A typical medium contains starch, corn steep liquor, calcium carbonate, casein, (NH4)2SO4, K2HPO4 and water. The pH of cultivation is 6.1 to 8.0 and temperature is 24 DEG to 37 DEG C. The broth is acidified to pH 2 to 2.5, clarified, treated with oxalic acid, clarified, adjusted to pH 8-8.5, extracted with a mixture of tricresol and CCl4, the organic phase separated, treated with aqueous HCl and acetone and oxytetracycline recovered from the aqueous phase at pH 7.0. The oxytetracycline may be converted into a salt with a mineral or organic acid, e.g. citric or tartaric acid. Other methods of isolation and purification are (a) solvent extraction with, e.g. butanol, (b) adsorption on, e.g. activated carbon, (c) precipitation with substances capable of forming insoluble derivatives, e.g. N,N1-malonylurea and sulphates.</description><language>fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; ENZYMOLOGY ; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE ; METALLURGY ; MICROBIOLOGY ; MUTATION OR GENETIC ENGINEERING ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>1966</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19660923&DB=EPODOC&CC=FR&NR=1453824A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19660923&DB=EPODOC&CC=FR&NR=1453824A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BARCHIELLI RICCARDO</creatorcontrib><creatorcontrib>CANEVAZZI GRAZIANA</creatorcontrib><creatorcontrib>GREIN ARPAD</creatorcontrib><title>Nouveau procédé de préparation de l'oxytétracycline, par fermentation à l'aide d'une nouvelle espèce de streptomyces</title><description>Oxytetracyline is produced by cultivating Streptomyces henetus (I.M.I. 109532; I.M. 3872) nor. spec. under aerobic conditions in a nutrient medium. 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| subjects | BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING SPIRITS VINEGAR WINE |
| title | Nouveau procédé de préparation de l'oxytétracycline, par fermentation à l'aide d'une nouvelle espèce de streptomyces |
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