Menetelmä alkoholin aiheuttaman annoksen vapautumisen vähentämiseksi optioidia viivästetysti vapauttavista oraalisista annostusmuodoista

Menetelmä alkoholin aiheuttaman annoksen vapautumisen vähentämiseksi optioidia viivästetysti vapauttavista oraalisista annostusmuodoista

Oral dosage form comprises an opioid and a dosing structure that provides extended release of the opioid in the presence of aqueous alcohol with an alcohol concentration of at least 20 vol.%, such that the ratio of the mean unit dose maximum opioid plasma concentration with alcohol coadminstration t...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: PORS,LINDA HEARNEY, HASTEDT,JAYNE, DAVAR,NIPUN, CASADEVALL,GEMMA, SATHYAN,GAYATRI
Format: Patent
Sprache:fin ; swe
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue
container_start_page
container_title
container_volume
creator PORS,LINDA HEARNEY
HASTEDT,JAYNE
DAVAR,NIPUN
CASADEVALL,GEMMA
SATHYAN,GAYATRI
description Oral dosage form comprises an opioid and a dosing structure that provides extended release of the opioid in the presence of aqueous alcohol with an alcohol concentration of at least 20 vol.%, such that the ratio of the mean unit dose maximum opioid plasma concentration with alcohol coadminstration to the mean unit dose maximum opioid plasma concentration without alcohol co-adminstration is no more than 1.8:1. Independent claims are also included for: (1) oral dosage form comprising an opioid and a dosing structure that provides extended release of the opioid in the presence of aqueous alcohol with an alcohol concentration of at least 20 vol.%, such that the ratio of an individual patient unit dose maximum opioid plasma concentration with alcohol coadminstration to the individual unit dose maximum opioid plasma concentration without alcohol coadminstration is no more than 5:1; (2) oral dosage form comprising an opioid and a dosing structure that provides extended release of the opioid in the presence of aqueous alcohol with an alcohol concentration of at least 20 vol.%, such that no more than 80% of the dose is released in 2 hours in an in-vitro test performed in the presence of at least 20 vol.% alcohol. ACTIVITY : Analgesic. MECHANISM OF ACTION : None given.
format Patent
fullrecord <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_FIU20060451UU0</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>FIU20060451UU0</sourcerecordid><originalsourceid>FETCH-epo_espacenet_FIU20060451UU03</originalsourceid><addsrcrecordid>eNqNjksKwkAQRLNxIeodBlwL8XsBMejCnVmHxrSkycx0sHsC3sFj5Ca5mJmQA7iqV9Ufap587-hR0bq-M2BrrtiSN0AVBlVwMLD3XAt600IDQYOj0fRdhV77LtpayHCjxFQSmJZomIqifkRpOlNoSRQMvwEsycjxs2gQF7jkmCyT2Qus4GrSRbLOLo_zdYMNFygNPGPZIrvluzQ9pYfjNs_T_X9bP1U8VVM</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Menetelmä alkoholin aiheuttaman annoksen vapautumisen vähentämiseksi optioidia viivästetysti vapauttavista oraalisista annostusmuodoista</title><source>esp@cenet</source><creator>PORS,LINDA HEARNEY ; HASTEDT,JAYNE ; DAVAR,NIPUN ; CASADEVALL,GEMMA ; SATHYAN,GAYATRI</creator><creatorcontrib>PORS,LINDA HEARNEY ; HASTEDT,JAYNE ; DAVAR,NIPUN ; CASADEVALL,GEMMA ; SATHYAN,GAYATRI</creatorcontrib><description>Oral dosage form comprises an opioid and a dosing structure that provides extended release of the opioid in the presence of aqueous alcohol with an alcohol concentration of at least 20 vol.%, such that the ratio of the mean unit dose maximum opioid plasma concentration with alcohol coadminstration to the mean unit dose maximum opioid plasma concentration without alcohol co-adminstration is no more than 1.8:1. Independent claims are also included for: (1) oral dosage form comprising an opioid and a dosing structure that provides extended release of the opioid in the presence of aqueous alcohol with an alcohol concentration of at least 20 vol.%, such that the ratio of an individual patient unit dose maximum opioid plasma concentration with alcohol coadminstration to the individual unit dose maximum opioid plasma concentration without alcohol coadminstration is no more than 5:1; (2) oral dosage form comprising an opioid and a dosing structure that provides extended release of the opioid in the presence of aqueous alcohol with an alcohol concentration of at least 20 vol.%, such that no more than 80% of the dose is released in 2 hours in an in-vitro test performed in the presence of at least 20 vol.% alcohol. ACTIVITY : Analgesic. MECHANISM OF ACTION : None given.</description><language>fin ; swe</language><creationdate>2006</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20061030&amp;DB=EPODOC&amp;CC=FI&amp;NR=U20060451U0$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76294</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20061030&amp;DB=EPODOC&amp;CC=FI&amp;NR=U20060451U0$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>PORS,LINDA HEARNEY</creatorcontrib><creatorcontrib>HASTEDT,JAYNE</creatorcontrib><creatorcontrib>DAVAR,NIPUN</creatorcontrib><creatorcontrib>CASADEVALL,GEMMA</creatorcontrib><creatorcontrib>SATHYAN,GAYATRI</creatorcontrib><title>Menetelmä alkoholin aiheuttaman annoksen vapautumisen vähentämiseksi optioidia viivästetysti vapauttavista oraalisista annostusmuodoista</title><description>Oral dosage form comprises an opioid and a dosing structure that provides extended release of the opioid in the presence of aqueous alcohol with an alcohol concentration of at least 20 vol.%, such that the ratio of the mean unit dose maximum opioid plasma concentration with alcohol coadminstration to the mean unit dose maximum opioid plasma concentration without alcohol co-adminstration is no more than 1.8:1. Independent claims are also included for: (1) oral dosage form comprising an opioid and a dosing structure that provides extended release of the opioid in the presence of aqueous alcohol with an alcohol concentration of at least 20 vol.%, such that the ratio of an individual patient unit dose maximum opioid plasma concentration with alcohol coadminstration to the individual unit dose maximum opioid plasma concentration without alcohol coadminstration is no more than 5:1; (2) oral dosage form comprising an opioid and a dosing structure that provides extended release of the opioid in the presence of aqueous alcohol with an alcohol concentration of at least 20 vol.%, such that no more than 80% of the dose is released in 2 hours in an in-vitro test performed in the presence of at least 20 vol.% alcohol. ACTIVITY : Analgesic. MECHANISM OF ACTION : None given.</description><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2006</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjksKwkAQRLNxIeodBlwL8XsBMejCnVmHxrSkycx0sHsC3sFj5Ca5mJmQA7iqV9Ufap587-hR0bq-M2BrrtiSN0AVBlVwMLD3XAt600IDQYOj0fRdhV77LtpayHCjxFQSmJZomIqifkRpOlNoSRQMvwEsycjxs2gQF7jkmCyT2Qus4GrSRbLOLo_zdYMNFygNPGPZIrvluzQ9pYfjNs_T_X9bP1U8VVM</recordid><startdate>20061030</startdate><enddate>20061030</enddate><creator>PORS,LINDA HEARNEY</creator><creator>HASTEDT,JAYNE</creator><creator>DAVAR,NIPUN</creator><creator>CASADEVALL,GEMMA</creator><creator>SATHYAN,GAYATRI</creator><scope>EVB</scope></search><sort><creationdate>20061030</creationdate><title>Menetelmä alkoholin aiheuttaman annoksen vapautumisen vähentämiseksi optioidia viivästetysti vapauttavista oraalisista annostusmuodoista</title><author>PORS,LINDA HEARNEY ; HASTEDT,JAYNE ; DAVAR,NIPUN ; CASADEVALL,GEMMA ; SATHYAN,GAYATRI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_FIU20060451UU03</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>fin ; swe</language><creationdate>2006</creationdate><toplevel>online_resources</toplevel><creatorcontrib>PORS,LINDA HEARNEY</creatorcontrib><creatorcontrib>HASTEDT,JAYNE</creatorcontrib><creatorcontrib>DAVAR,NIPUN</creatorcontrib><creatorcontrib>CASADEVALL,GEMMA</creatorcontrib><creatorcontrib>SATHYAN,GAYATRI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>PORS,LINDA HEARNEY</au><au>HASTEDT,JAYNE</au><au>DAVAR,NIPUN</au><au>CASADEVALL,GEMMA</au><au>SATHYAN,GAYATRI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Menetelmä alkoholin aiheuttaman annoksen vapautumisen vähentämiseksi optioidia viivästetysti vapauttavista oraalisista annostusmuodoista</title><date>2006-10-30</date><risdate>2006</risdate><abstract>Oral dosage form comprises an opioid and a dosing structure that provides extended release of the opioid in the presence of aqueous alcohol with an alcohol concentration of at least 20 vol.%, such that the ratio of the mean unit dose maximum opioid plasma concentration with alcohol coadminstration to the mean unit dose maximum opioid plasma concentration without alcohol co-adminstration is no more than 1.8:1. Independent claims are also included for: (1) oral dosage form comprising an opioid and a dosing structure that provides extended release of the opioid in the presence of aqueous alcohol with an alcohol concentration of at least 20 vol.%, such that the ratio of an individual patient unit dose maximum opioid plasma concentration with alcohol coadminstration to the individual unit dose maximum opioid plasma concentration without alcohol coadminstration is no more than 5:1; (2) oral dosage form comprising an opioid and a dosing structure that provides extended release of the opioid in the presence of aqueous alcohol with an alcohol concentration of at least 20 vol.%, such that no more than 80% of the dose is released in 2 hours in an in-vitro test performed in the presence of at least 20 vol.% alcohol. ACTIVITY : Analgesic. MECHANISM OF ACTION : None given.</abstract><oa>free_for_read</oa></addata></record>
fulltext fulltext_linktorsrc
identifier
ispartof
issn
language fin ; swe
recordid cdi_epo_espacenet_FIU20060451UU0
source esp@cenet
title Menetelmä alkoholin aiheuttaman annoksen vapautumisen vähentämiseksi optioidia viivästetysti vapauttavista oraalisista annostusmuodoista
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-23T11%3A04%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=PORS,LINDA%20HEARNEY&rft.date=2006-10-30&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EFIU20060451UU0%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true