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PCT No. PCT/SE94/00152 Sec. 371 Date May 4, 1995 Sec. 102(e) Date May 4, 1995 PCT Filed Feb. 22, 1994 PCT Pub. No. WO94/19315 PCT Pub. Date Sep. 1, 1994 (I) The present invention relates to novel derivatives of 3-hydroxyanthranilic acid, 3-HANA of general formula (I), wherein R1 and R2 are the same...

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Hauptverfasser:	BJOERK, SUSANNA KARIN MARIA, GOTTHAMMAR, KRISTINA BIRGITTA, PERSSON, KERSTIN MARGARETA IRMA, LINDERBERG, MATS TORBJOERN, SCHWARCZ, ROBERT, LUTHMAN, PER JOHAN
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Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator	BJOERK, SUSANNA KARIN MARIA GOTTHAMMAR, KRISTINA BIRGITTA PERSSON, KERSTIN MARGARETA IRMA LINDERBERG, MATS TORBJOERN SCHWARCZ, ROBERT LUTHMAN, PER JOHAN
description	PCT No. PCT/SE94/00152 Sec. 371 Date May 4, 1995 Sec. 102(e) Date May 4, 1995 PCT Filed Feb. 22, 1994 PCT Pub. No. WO94/19315 PCT Pub. Date Sep. 1, 1994 (I) The present invention relates to novel derivatives of 3-hydroxyanthranilic acid, 3-HANA of general formula (I), wherein R1 and R2 are the same or different and selected from H and alkyl; X is selected from alkylthio, arylthio, aryloxy, halogen and cyano; R3, R4 are the same or different and selected from halogen, methyl, fluoroalkyl, cyano and Z-R5 wherein Z is selected from CHn, NHm, O, S, SO2 and CO wherein n=1 or 2; m=0 or 1 and R5 is selected from alkyl, aryl and fluoroalkyl; or R3 and R4 together form a saturated or unsaturated ring system Y-V-Z wherein Y and Z, independently of each other, are as defined for Z above and V is selected from C1-C3 alkylene or alkenylene, -N=, -N=N- and (a), wherein R7=H or alkyl; or a pharmaceutically acceptable salt thereof, methods and intermediates for their preparation, novel pharmaceutical compositions and the use thereof for inhibiting the enzyme 3-hydroxy-anthranilate oxygenase, 3-HAO, responsible for the production of the endogenous neurotoxin quinolinic acid, QUIN.
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No. WO94/19315 PCT Pub. Date Sep. 1, 1994 (I) The present invention relates to novel derivatives of 3-hydroxyanthranilic acid, 3-HANA of general formula (I), wherein R1 and R2 are the same or different and selected from H and alkyl; X is selected from alkylthio, arylthio, aryloxy, halogen and cyano; R3, R4 are the same or different and selected from halogen, methyl, fluoroalkyl, cyano and Z-R5 wherein Z is selected from CHn, NHm, O, S, SO2 and CO wherein n=1 or 2; m=0 or 1 and R5 is selected from alkyl, aryl and fluoroalkyl; or R3 and R4 together form a saturated or unsaturated ring system Y-V-Z wherein Y and Z, independently of each other, are as defined for Z above and V is selected from C1-C3 alkylene or alkenylene, -N=, -N=N- and (a), wherein R7=H or alkyl; or a pharmaceutically acceptable salt thereof, methods and intermediates for their preparation, novel pharmaceutical compositions and the use thereof for inhibiting the enzyme 3-hydroxy-anthranilate oxygenase, 3-HAO, responsible for the production of the endogenous neurotoxin quinolinic acid, QUIN.</description><edition>6</edition><language>fin ; swe</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1995</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19950825&DB=EPODOC&CC=FI&NR=954016A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19950825&DB=EPODOC&CC=FI&NR=954016A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BJOERK, SUSANNA KARIN MARIA</creatorcontrib><creatorcontrib>GOTTHAMMAR, KRISTINA BIRGITTA</creatorcontrib><creatorcontrib>PERSSON, KERSTIN MARGARETA IRMA</creatorcontrib><creatorcontrib>LINDERBERG, MATS TORBJOERN</creatorcontrib><creatorcontrib>SCHWARCZ, ROBERT</creatorcontrib><creatorcontrib>LUTHMAN, PER JOHAN</creatorcontrib><title>Uudet yhdisteet</title><description>PCT No. PCT/SE94/00152 Sec. 371 Date May 4, 1995 Sec. 102(e) Date May 4, 1995 PCT Filed Feb. 22, 1994 PCT Pub. 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Date Sep. 1, 1994 (I) The present invention relates to novel derivatives of 3-hydroxyanthranilic acid, 3-HANA of general formula (I), wherein R1 and R2 are the same or different and selected from H and alkyl; X is selected from alkylthio, arylthio, aryloxy, halogen and cyano; R3, R4 are the same or different and selected from halogen, methyl, fluoroalkyl, cyano and Z-R5 wherein Z is selected from CHn, NHm, O, S, SO2 and CO wherein n=1 or 2; m=0 or 1 and R5 is selected from alkyl, aryl and fluoroalkyl; or R3 and R4 together form a saturated or unsaturated ring system Y-V-Z wherein Y and Z, independently of each other, are as defined for Z above and V is selected from C1-C3 alkylene or alkenylene, -N=, -N=N- and (a), wherein R7=H or alkyl; or a pharmaceutically acceptable salt thereof, methods and intermediates for their preparation, novel pharmaceutical compositions and the use thereof for inhibiting the enzyme 3-hydroxy-anthranilate oxygenase, 3-HAO, responsible for the production of the endogenous neurotoxin quinolinic acid, QUIN.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1995</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZOAPLU1JLVGozEjJLC5JTS3hYWBNS8wpTuWF0twMcm6uIc4euqkF-fGpxQWJyal5qSXxbp6WpiYGhmaOxgQVAADcNR24</recordid><startdate>19950825</startdate><enddate>19950825</enddate><creator>BJOERK, SUSANNA KARIN MARIA</creator><creator>GOTTHAMMAR, KRISTINA BIRGITTA</creator><creator>PERSSON, KERSTIN MARGARETA IRMA</creator><creator>LINDERBERG, MATS TORBJOERN</creator><creator>SCHWARCZ, ROBERT</creator><creator>LUTHMAN, PER JOHAN</creator><scope>EVB</scope></search><sort><creationdate>19950825</creationdate><title>Uudet yhdisteet</title><author>BJOERK, SUSANNA KARIN MARIA ; GOTTHAMMAR, KRISTINA BIRGITTA ; PERSSON, KERSTIN MARGARETA IRMA ; LINDERBERG, MATS TORBJOERN ; SCHWARCZ, ROBERT ; LUTHMAN, PER JOHAN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_FI954016A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>fin ; swe</language><creationdate>1995</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>BJOERK, SUSANNA KARIN MARIA</creatorcontrib><creatorcontrib>GOTTHAMMAR, KRISTINA BIRGITTA</creatorcontrib><creatorcontrib>PERSSON, KERSTIN MARGARETA IRMA</creatorcontrib><creatorcontrib>LINDERBERG, MATS TORBJOERN</creatorcontrib><creatorcontrib>SCHWARCZ, ROBERT</creatorcontrib><creatorcontrib>LUTHMAN, PER JOHAN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>BJOERK, SUSANNA KARIN MARIA</au><au>GOTTHAMMAR, KRISTINA BIRGITTA</au><au>PERSSON, KERSTIN MARGARETA IRMA</au><au>LINDERBERG, MATS TORBJOERN</au><au>SCHWARCZ, ROBERT</au><au>LUTHMAN, PER JOHAN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Uudet yhdisteet</title><date>1995-08-25</date><risdate>1995</risdate><abstract>PCT No. PCT/SE94/00152 Sec. 371 Date May 4, 1995 Sec. 102(e) Date May 4, 1995 PCT Filed Feb. 22, 1994 PCT Pub. No. WO94/19315 PCT Pub. Date Sep. 1, 1994 (I) The present invention relates to novel derivatives of 3-hydroxyanthranilic acid, 3-HANA of general formula (I), wherein R1 and R2 are the same or different and selected from H and alkyl; X is selected from alkylthio, arylthio, aryloxy, halogen and cyano; R3, R4 are the same or different and selected from halogen, methyl, fluoroalkyl, cyano and Z-R5 wherein Z is selected from CHn, NHm, O, S, SO2 and CO wherein n=1 or 2; m=0 or 1 and R5 is selected from alkyl, aryl and fluoroalkyl; or R3 and R4 together form a saturated or unsaturated ring system Y-V-Z wherein Y and Z, independently of each other, are as defined for Z above and V is selected from C1-C3 alkylene or alkenylene, -N=, -N=N- and (a), wherein R7=H or alkyl; or a pharmaceutically acceptable salt thereof, methods and intermediates for their preparation, novel pharmaceutical compositions and the use thereof for inhibiting the enzyme 3-hydroxy-anthranilate oxygenase, 3-HAO, responsible for the production of the endogenous neurotoxin quinolinic acid, QUIN.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record>
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title	Uudet yhdisteet
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