1-substituoitujen (S)- ja (R)-2-aminometyylipyrrolidiinien tehokas, stereorakenteen säilyttävä synteesi sekä synteesin välituotteet

Stereoconservative method for preparation of an (R)- or (S)-isomer of the compound of the formula I with at least 95% optical purity wherein R is a hydrogen atom, a saturated or unsaturated lower alkyl group, a cycloalkyl group, or a group (CH2)m Ph wherein m is O-3 and Ph is a substituted or unsubs...

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Hauptverfasser: STROEM,HANS ERIC PETER, RAEMSBY,STEN INGVAR, HOEGBERG,THOMAS, FEDERSEL,HANS-JUERGEN
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creator STROEM,HANS ERIC PETER
RAEMSBY,STEN INGVAR
HOEGBERG,THOMAS
FEDERSEL,HANS-JUERGEN
description Stereoconservative method for preparation of an (R)- or (S)-isomer of the compound of the formula I with at least 95% optical purity wherein R is a hydrogen atom, a saturated or unsaturated lower alkyl group, a cycloalkyl group, or a group (CH2)m Ph wherein m is O-3 and Ph is a substituted or unsubstituted phenyl group including l) O,N-dialkylation, directly or stepwise of (R)- or (S)-proline 2) aminolysis 3) reduction to formation of the (R)- or (S)-isomer of the compound of the formula I, and new intermediates II and III in optical active form obtained by the reaction steps above and wherein R is defined as R above. h
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subjects APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title 1-substituoitujen (S)- ja (R)-2-aminometyylipyrrolidiinien tehokas, stereorakenteen säilyttävä synteesi sekä synteesin välituotteet
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