Substituoituja pyridopyrmidiinejä korkean verenpaineen vastaisina aineina

This invention relates to intermediates useful in the production of substituted pyridopyrimidinones of general formula (I): wherein n is 0 to 3; R and R are, independently, H, C1-C6alkyl, hydroxy(C1-C6alkyl), formyl, carbonyl(C1-C6alkyl), carboxy, or carboxy(C1-C6alkyl); R and R are, independently,...

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1. Verfasser: ELLINGBOE, JOHN WATSON
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description This invention relates to intermediates useful in the production of substituted pyridopyrimidinones of general formula (I): wherein n is 0 to 3; R and R are, independently, H, C1-C6alkyl, hydroxy(C1-C6alkyl), formyl, carbonyl(C1-C6alkyl), carboxy, or carboxy(C1-C6alkyl); R and R are, independently, H, C1-C6alkyl, or hydroxy; R and R are H, or one of -CR R and -CR R is a carbonyl group; with the proviso that at least one of the groups R and R must be hydroxy(C1-C6alkyl), formyl, carbonyl(C1-C6alkyl), carboxy, or carboxy(C1-C6alkyl); or one of R and R must be hydroxy; or one of -CR R and -CR R must be a carbonyl group; ; Ar is wherein W is H, C1-C6alkyl, halogen, hydroxy, or C1-C6alkoxy; Ar is wherein X is wherein R is H, CH3, tert-butyl, tri-n-butylstannyl, or triphenylmethyl; or a tautomer of said compound, or a pharmaceutically acceptable salt of said compound or tautomer. The compounds of Formula I are useful for treating hypertension and congestive heart failure. Also disclosed are pharmaceutical compositions containing compounds of Formula I and a pharmaceutically acceptable carrier and methods for production of the compounds of Formula I. Intermediates for making the pharmaceutical useful compounds are also enclosed.
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The compounds of Formula I are useful for treating hypertension and congestive heart failure. Also disclosed are pharmaceutical compositions containing compounds of Formula I and a pharmaceutically acceptable carrier and methods for production of the compounds of Formula I. 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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Substituoituja pyridopyrmidiinejä korkean verenpaineen vastaisina aineina
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