Menetelmä 1- 2-/5-dimetyyliaminometyyli-2-(furyylimetyylitio)etyyli/ amino-1-metyyliamino-2-nitroeteenin ja sen hydrokloridin valmistamiseksi

1-{2-[5-dimethylaminomethyl-2-(furylmethylthio)-ethyl]}-amino-1-methyl amino-2 - nitroethylene of the formula (I> and its hydrochloride, are prepared by reacting an 1-{2-[5-dimethylaminomethyl-2-(furylmethylthio)-ethyl]}-amino-1-(subst ituted thio)-2- nitroethylene of the formula (VI), wherein R...

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Bibliographische Detailangaben
Hauptverfasser:	LANG,TIBOR, KOCZKA NEE FALTA,EVA, HORVATH,GYULA, KASZTREINER,ENDRE, STEFKO,BELA, TOLDY,LAJOS, USKERT NEE DIEVALD,EMILIA, MAKK,NANDOR, DIESLER,ESZTER, BOBAK NEE SZEKERES,DORA, MATYUS,PETER, SOMOGYI,TIBOR, BALOGH,TIBOR, SZEDERKENYI,FERENC, LAZAR,ARPAD
Format:	Patent
Sprache:	fin ; swe
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	1-{2-[5-dimethylaminomethyl-2-(furylmethylthio)-ethyl]}-amino-1-methyl amino-2 - nitroethylene of the formula (I> and its hydrochloride, are prepared by reacting an 1-{2-[5-dimethylaminomethyl-2-(furylmethylthio)-ethyl]}-amino-1-(subst ituted thio)-2- nitroethylene of the formula (VI), wherein R represents an optionally substituted C1-4 alkyl group or an oxoalkyl, aryl, aralkyl, or oxoaralkyl group, with an agent capable of splitting off a mercapten, in an organic solvent, optionally in the presence of an acid-binding agent, then reacting the in situ prepared 1-{2-[5-dimethylaminomethyl-2-(furylmethylthio)-ethyl]}-3-nitroketenei mine of the formula (VII> with methylamine and finally, if desired, separating the obtained base of formula (I), purifying it and/or, if desired, transforming it to its hydrochloric salt.