FOERFARANDE FOER FRAMSTAELLNING AV NYA TERAPEUTISKT ANVAENDBARA TRANS-3-(4-OXO-4H-KINAZOLIN-3-YL)-2- PROPENSYRADERIVAT

Trans-3-(4-oxo-4H-quinazolin-3-yl)-2-propenoic acid derivatives of the formula I wherein R1 is hydrogen, lower alkyl, lower cycloalkyl, lower alkoxy, hydroxy, halo, lower alkykthio, lower alkylsulfinyl, lower alkylsulfonyl, di-(C1-C7)alkyl-N(CH2)nO- or 2-hydroxyethoxy; R2 is hydrogen, lower alkyl or...

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Hauptverfasser:	LEMAHIEU, RONALD ANDREW, NASON, WILLIAM CHESTER
Format:	Patent
Sprache:	fin
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
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creator	LEMAHIEU, RONALD ANDREW NASON, WILLIAM CHESTER
description	Trans-3-(4-oxo-4H-quinazolin-3-yl)-2-propenoic acid derivatives of the formula I wherein R1 is hydrogen, lower alkyl, lower cycloalkyl, lower alkoxy, hydroxy, halo, lower alkykthio, lower alkylsulfinyl, lower alkylsulfonyl, di-(C1-C7)alkyl-N(CH2)nO- or 2-hydroxyethoxy; R2 is hydrogen, lower alkyl or lower alkoxy; R3 is hydroxy, lower alkoxy, di-(C1-C7)alkyl-N(CH2)nO- or di-(C1-C7)alkyl-N(CH2)nNH-; and n is 2 to 7; provided that at least one of R1 and R2 is other than hydrogen, when R3 is hydroxy, a salt thereof with a pharmaceutically acceptable base, or when R3 is di-(C1-C7)alkyl-N(CH2)nO- or di-(C1-C7)alkyl-N(CH2)nNH-, a salt thereof with a pharmaceutically acceptable acid, and a process for the preparation thereof, are described. The compounds of formula I are useful as agents in the prevention of allergic reactions.
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The compounds of formula I are useful as agents in the prevention of allergic reactions.</description><edition>4</edition><language>fin</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>1987</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19870930&DB=EPODOC&CC=FI&NR=74279B$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25544,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19870930&DB=EPODOC&CC=FI&NR=74279B$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LEMAHIEU, RONALD ANDREW</creatorcontrib><creatorcontrib>NASON, WILLIAM CHESTER</creatorcontrib><title>FOERFARANDE FOER FRAMSTAELLNING AV NYA TERAPEUTISKT ANVAENDBARA TRANS-3-(4-OXO-4H-KINAZOLIN-3-YL)-2- PROPENSYRADERIVAT</title><description>Trans-3-(4-oxo-4H-quinazolin-3-yl)-2-propenoic acid derivatives of the formula I wherein R1 is hydrogen, lower alkyl, lower cycloalkyl, lower alkoxy, hydroxy, halo, lower alkykthio, lower alkylsulfinyl, lower alkylsulfonyl, di-(C1-C7)alkyl-N(CH2)nO- or 2-hydroxyethoxy; R2 is hydrogen, lower alkyl or lower alkoxy; R3 is hydroxy, lower alkoxy, di-(C1-C7)alkyl-N(CH2)nO- or di-(C1-C7)alkyl-N(CH2)nNH-; and n is 2 to 7; provided that at least one of R1 and R2 is other than hydrogen, when R3 is hydroxy, a salt thereof with a pharmaceutically acceptable base, or when R3 is di-(C1-C7)alkyl-N(CH2)nO- or di-(C1-C7)alkyl-N(CH2)nNH-, a salt thereof with a pharmaceutically acceptable acid, and a process for the preparation thereof, are described. The compounds of formula I are useful as agents in the prevention of allergic reactions.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1987</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqFi7EKwjAURbs4iPoLklGHt7SF4vhqX2xofClJLNalFImTaKHi91vB3elcDvfMo7c0ZCVa5ILEdwtp8eg8ktas-CCwEdyi8GSxppNXrvICuUHiIp8y4afUQQKbFMzZQFpCpRgvRiuebKu3EIOoramJXWuxIKsa9MtoduvvY1j9uIjWkvy-hDA8uzAO_TU8wquTKkvjbJfnyd_DB7MkOAw</recordid><startdate>19870930</startdate><enddate>19870930</enddate><creator>LEMAHIEU, RONALD ANDREW</creator><creator>NASON, WILLIAM CHESTER</creator><scope>EVB</scope></search><sort><creationdate>19870930</creationdate><title>FOERFARANDE FOER FRAMSTAELLNING AV NYA TERAPEUTISKT ANVAENDBARA TRANS-3-(4-OXO-4H-KINAZOLIN-3-YL)-2- PROPENSYRADERIVAT</title><author>LEMAHIEU, RONALD ANDREW ; NASON, WILLIAM CHESTER</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_FI74279BB3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>fin</language><creationdate>1987</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>LEMAHIEU, RONALD ANDREW</creatorcontrib><creatorcontrib>NASON, WILLIAM CHESTER</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LEMAHIEU, RONALD ANDREW</au><au>NASON, WILLIAM CHESTER</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>FOERFARANDE FOER FRAMSTAELLNING AV NYA TERAPEUTISKT ANVAENDBARA TRANS-3-(4-OXO-4H-KINAZOLIN-3-YL)-2- PROPENSYRADERIVAT</title><date>1987-09-30</date><risdate>1987</risdate><abstract>Trans-3-(4-oxo-4H-quinazolin-3-yl)-2-propenoic acid derivatives of the formula I wherein R1 is hydrogen, lower alkyl, lower cycloalkyl, lower alkoxy, hydroxy, halo, lower alkykthio, lower alkylsulfinyl, lower alkylsulfonyl, di-(C1-C7)alkyl-N(CH2)nO- or 2-hydroxyethoxy; R2 is hydrogen, lower alkyl or lower alkoxy; R3 is hydroxy, lower alkoxy, di-(C1-C7)alkyl-N(CH2)nO- or di-(C1-C7)alkyl-N(CH2)nNH-; and n is 2 to 7; provided that at least one of R1 and R2 is other than hydrogen, when R3 is hydroxy, a salt thereof with a pharmaceutically acceptable base, or when R3 is di-(C1-C7)alkyl-N(CH2)nO- or di-(C1-C7)alkyl-N(CH2)nNH-, a salt thereof with a pharmaceutically acceptable acid, and a process for the preparation thereof, are described. The compounds of formula I are useful as agents in the prevention of allergic reactions.</abstract><edition>4</edition><oa>free_for_read</oa></addata></record>
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subjects	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
title	FOERFARANDE FOER FRAMSTAELLNING AV NYA TERAPEUTISKT ANVAENDBARA TRANS-3-(4-OXO-4H-KINAZOLIN-3-YL)-2- PROPENSYRADERIVAT
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