FOERFARANDE FOER FRAMSTAELLNING AV 2-(4-(2-FUROYL)PIPERAZIN-1-YL)-4-AMINO-6,7-DIMETOXIKINAZOLIN OCH EN MELLANPRODUKT FOER ANVAENDNING VID FOERFARANDET

Novel compounds of the general formula II in which X represents a chlorine, bromine or iodine atom, and n denotes an integer from 1 to 3, are obtained by reacting a 6,7-dimethoxyquinazoline with a halogen-substituted furan. The compounds obtained can then be reacted at a temperature from 0 DEG to 15...

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1. Verfasser:	HAMMEN PHILIP DIETRICH
Format:	Patent
Sprache:	fin
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator	HAMMEN PHILIP DIETRICH
description	Novel compounds of the general formula II in which X represents a chlorine, bromine or iodine atom, and n denotes an integer from 1 to 3, are obtained by reacting a 6,7-dimethoxyquinazoline with a halogen-substituted furan. The compounds obtained can then be reacted at a temperature from 0 DEG to 150 DEG C with hydrogen in the presence of a catalytic amount of a dehalogenating catalyst and in the presence of a solvent which is inert to the reaction. The compound 2-[4-(2-furoyl)piperazin-1-yl]-4-amino-6,7-dimethoxy-quinazoline which can be prepared according to the invention is in general useful on account of its ability to lower the blood pressure in mammals having high blood pressure.
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The compounds obtained can then be reacted at a temperature from 0 DEG to 150 DEG C with hydrogen in the presence of a catalytic amount of a dehalogenating catalyst and in the presence of a solvent which is inert to the reaction. The compound 2-[4-(2-furoyl)piperazin-1-yl]-4-amino-6,7-dimethoxy-quinazoline which can be prepared according to the invention is in general useful on account of its ability to lower the blood pressure in mammals having high blood pressure.</description><edition>3</edition><language>fin</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>1984</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19840810&DB=EPODOC&CC=FI&NR=65999C$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19840810&DB=EPODOC&CC=FI&NR=65999C$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HAMMEN PHILIP DIETRICH</creatorcontrib><title>FOERFARANDE FOER FRAMSTAELLNING AV 2-(4-(2-FUROYL)PIPERAZIN-1-YL)-4-AMINO-6,7-DIMETOXIKINAZOLIN OCH EN MELLANPRODUKT FOER ANVAENDNING VID FOERFARANDET</title><description>Novel compounds of the general formula II in which X represents a chlorine, bromine or iodine atom, and n denotes an integer from 1 to 3, are obtained by reacting a 6,7-dimethoxyquinazoline with a halogen-substituted furan. 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The compound 2-[4-(2-furoyl)piperazin-1-yl]-4-amino-6,7-dimethoxy-quinazoline which can be prepared according to the invention is in general useful on account of its ability to lower the blood pressure in mammals having high blood pressure.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1984</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqFjr0KwkAQhNNYiPoKcmUEtzBGJeWSuzNLkr1wnkHTiMhZiQr6LD6v8aews5oZGOabbvDQRlmNFlkq8fJCWyxXDlVRMPFSYC0iCGMII9Bra7bFqKJKWWyIYQJthBiwJDYwHy9AUqmc2VBOjI0piIVJM6FYlO0ecmWNXOfuA0KuUbF8U2qS4ueJ6wed4_5084Ov9oKhVi7NwF8vO3-77g_-7O87TfNZkiRpOv1beAK4SkBj</recordid><startdate>19840810</startdate><enddate>19840810</enddate><creator>HAMMEN PHILIP DIETRICH</creator><scope>EVB</scope></search><sort><creationdate>19840810</creationdate><title>FOERFARANDE FOER FRAMSTAELLNING AV 2-(4-(2-FUROYL)PIPERAZIN-1-YL)-4-AMINO-6,7-DIMETOXIKINAZOLIN OCH EN MELLANPRODUKT FOER ANVAENDNING VID FOERFARANDET</title><author>HAMMEN PHILIP DIETRICH</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_FI65999CC3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>fin</language><creationdate>1984</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>HAMMEN PHILIP DIETRICH</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HAMMEN PHILIP DIETRICH</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>FOERFARANDE FOER FRAMSTAELLNING AV 2-(4-(2-FUROYL)PIPERAZIN-1-YL)-4-AMINO-6,7-DIMETOXIKINAZOLIN OCH EN MELLANPRODUKT FOER ANVAENDNING VID FOERFARANDET</title><date>1984-08-10</date><risdate>1984</risdate><abstract>Novel compounds of the general formula II in which X represents a chlorine, bromine or iodine atom, and n denotes an integer from 1 to 3, are obtained by reacting a 6,7-dimethoxyquinazoline with a halogen-substituted furan. The compounds obtained can then be reacted at a temperature from 0 DEG to 150 DEG C with hydrogen in the presence of a catalytic amount of a dehalogenating catalyst and in the presence of a solvent which is inert to the reaction. The compound 2-[4-(2-furoyl)piperazin-1-yl]-4-amino-6,7-dimethoxy-quinazoline which can be prepared according to the invention is in general useful on account of its ability to lower the blood pressure in mammals having high blood pressure.</abstract><edition>3</edition><oa>free_for_read</oa></addata></record>
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subjects	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title	FOERFARANDE FOER FRAMSTAELLNING AV 2-(4-(2-FUROYL)PIPERAZIN-1-YL)-4-AMINO-6,7-DIMETOXIKINAZOLIN OCH EN MELLANPRODUKT FOER ANVAENDNING VID FOERFARANDET
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