ANALOGIFOERFARANDE FOER FRAMSTAELLNING AV FARMACEUTISKT ANVAENDBARA 2-DEOXI-2-NIKOTINAMIDO-1-0-NIKOTINOYL-GLUKOPYRANOS-DERIVAT

1451181 2 - Nicotinamides - 1 - nicotinoyloxy- 0-glycopyranoses F HOFFMAN-LA ROCHE AG 24 Jan 1975 [25 Jan 1974] 3180/75 Heading C2C Novel compounds I in which R is C 1-6 alkanoyl, C 1-6 alkoxy C 1-6 alkanoyl or aryl are prepared by replacing X in a compound II where X is halogen or optionally protec...

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Hauptverfasser:	LENGSFELD HANS, WYSS PIERREARLES, GEY KARL FRIEDRICH, SCHUEEP WILLY, KISS JOSEPH
Format:	Patent
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Schlagworte:	CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SUGARS
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creator	LENGSFELD HANS WYSS PIERREARLES GEY KARL FRIEDRICH SCHUEEP WILLY KISS JOSEPH
description	1451181 2 - Nicotinamides - 1 - nicotinoyloxy- 0-glycopyranoses F HOFFMAN-LA ROCHE AG 24 Jan 1975 [25 Jan 1974] 3180/75 Heading C2C Novel compounds I in which R is C 1-6 alkanoyl, C 1-6 alkoxy C 1-6 alkanoyl or aryl are prepared by replacing X in a compound II where X is halogen or optionally protected hydroxy, by a nicotinoyloxy group in known manner. Compounds I (R=acetyl, propionyl, benzoyl) are prepared. Compound II (X=Cl, R=acetyl) is prepared by reacting N-nicotinoyl-D-glucosamine with acetyl chloride. Compound II (X=acetoxy, R=acetyl) is prepared by reacting 1,3,4,6- tetra - O - acetyl - D - glucosamine with nicotinic acid. Compounds I have plasma lipid-lowering activity and form with a carrier a pharmaceutical composition which may be administered orally, parenterally or rectally.
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Compounds I (R=acetyl, propionyl, benzoyl) are prepared. Compound II (X=Cl, R=acetyl) is prepared by reacting N-nicotinoyl-D-glucosamine with acetyl chloride. Compound II (X=acetoxy, R=acetyl) is prepared by reacting 1,3,4,6- tetra - O - acetyl - D - glucosamine with nicotinic acid. 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subjects	CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SUGARS
title	ANALOGIFOERFARANDE FOER FRAMSTAELLNING AV FARMACEUTISKT ANVAENDBARA 2-DEOXI-2-NIKOTINAMIDO-1-0-NIKOTINOYL-GLUKOPYRANOS-DERIVAT
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