Modifioitu beeta-laktamaasi ja menetelmä sen valmistamiseksi

Modifioitu beeta-laktamaasi ja menetelmä sen valmistamiseksi

The invention relates to targeted post translational modification of metallo-beta-lactamase by truncation and insertion of a dipeptide at the amino terminal end to reduce amino terminal heterogeneity in a recombinant DNA production system. A protein K-T-E- BL is expressed, and modified by host prote...

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Hauptverfasser: KAEAERIAEINEN,SUSANNA, WICKSTRAND,NINA, KOSKI,PERTTI
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Sprache:fin ; swe
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CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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creator KAEAERIAEINEN,SUSANNA
WICKSTRAND,NINA
KOSKI,PERTTI
description The invention relates to targeted post translational modification of metallo-beta-lactamase by truncation and insertion of a dipeptide at the amino terminal end to reduce amino terminal heterogeneity in a recombinant DNA production system. A protein K-T-E- BL is expressed, and modified by host proteases to E- BL. Appropriate nucleotide molecules, vectors and hosts are also described. E- BL is useful in a pharmaceutical composition for treating antibiotic induced adverse effects in the intestine of patients treated with beta-lactam antibiotics.
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subjects CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
title Modifioitu beeta-laktamaasi ja menetelmä sen valmistamiseksi
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