Derivados de imidazol condensados como moduladores de IL-17

En consecuencia, una serie de derivados de imidazol bicíclicos fusionados sustituidos, incluidos derivados de bencimidazol y análogos de los mismos, que son potentes moduladores de la actividad de la IL-17 humana, son beneficiosos en el tratamiento y/o prevención de diversas dolencias humanas, inclu...

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Hauptverfasser: YAU, Wei Tsung, ZHU, Zhaoning, TAYLOR, Richard David, HORSLEY, Helen Tracey, SCHULZE, Monika-Sarah Elisabeth Dorothea, FOULKES, Gregory, BRACE, Gareth Neil, CHAPPELL, Rose Elizabeth, FROST, James Richard, JONES, Elizabeth Pearl, REUBERSON, James Thomas, LECOMTE, Fabien Claude
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creator YAU, Wei Tsung
ZHU, Zhaoning
TAYLOR, Richard David
HORSLEY, Helen Tracey
SCHULZE, Monika-Sarah Elisabeth Dorothea
FOULKES, Gregory
BRACE, Gareth Neil
CHAPPELL, Rose Elizabeth
FROST, James Richard
JONES, Elizabeth Pearl
REUBERSON, James Thomas
LECOMTE, Fabien Claude
description En consecuencia, una serie de derivados de imidazol bicíclicos fusionados sustituidos, incluidos derivados de bencimidazol y análogos de los mismos, que son potentes moduladores de la actividad de la IL-17 humana, son beneficiosos en el tratamiento y/o prevención de diversas dolencias humanas, incluidos trastornos inflamatorios y autoinmunes. (Traducción automática con Google Translate, sin valor legal) A series of substituted fused bicyclic imidazole derivatives, including benzimidazole derivatives and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Derivados de imidazol condensados como moduladores de IL-17
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