Matrices de tejidos con porosidad o propiedades mecánicas controladas

Un dispositivo para el tratamiento de un defecto anatómico, que comprende: un sustrato de material polimérico sintético; y una matriz acelular de tejido incrustada en la estructura reticulada del sustrato de material polimérico sintético, en donde la matriz acelular de tejido comprende una matriz de tejido adiposo. The present disclosure provides tissue products produced from extracellular tissue matrices. The tissue products can include acellular extracellular matrices that have been treated in select areas to increase the compressive modulus of the matrix in the selected area while maintaining the ability to support cell growth and tissue regeneration. In addition, the tissue products can include collagen-containing materials that support tissue ingrowth along with a framework of collagenous or polymeric materials such that the combination has a desired compressive or tensile modulus and/or strength while maintaining the ability to support cell growth and tissue regeneration.