Variantes de polimerasa
Una ADN polimerasa modificada que tiene una actividad ADN polimerasa que comprende una secuencia de aminoácidos que tiene al menos un 70 % de identidad de secuencia con respecto a la secuencia de aminoácidos como se expone en SEQ ID NO: 2, secuencia de aminoácidos que tiene una sustitución de acuerd...
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| creator | MCGAW, Colin Alexander SUKO, Shawn SCHULTZ, Tyler O'Brien BIBILLO, Arkadiusz ECKERT, Barbara WUNDERLICH, David Daniel BOENITZ-DULAT, Mara THAI, Eileen LEDERMAN, Ilya ARNOLD, Cleoma Renetta WOERSDOERFER, Bigna SCHWAB, Charles Wayan AYER, Aruna |
| description | Una ADN polimerasa modificada que tiene una actividad ADN polimerasa que comprende una secuencia de aminoácidos que tiene al menos un 70 % de identidad de secuencia con respecto a la secuencia de aminoácidos como se expone en SEQ ID NO: 2, secuencia de aminoácidos que tiene una sustitución de acuerdo con S366 A/L y que opcionalmente incluye una o más sustituciones aminoacídicas seleccionadas del grupo que consiste en H223, N224, Y225, H227, I295, Y342, T343, I357, S360, L361, I363, S365Q, Y367, P368, D417, E475, Y476, F478, K518, H527, T529, M531, N535, G539, P542, N545, Q546, A547, L549, I550, N552, G553, F558, A596, G603, A610, V615, Y622, C623, D624, I628, Y629, R632, N635, M641, A643, I644, T647, I648, T651, I652, K655, W656, D657, V658, H660, F662, L690 y combinaciones de las mismas.
Described herein is a variant pol6 polymerase having at least one mutation selected from H223, N224, Y225, H227, I295, Y342, T343, I357, S360, L361, I363, S365, S366, Y367, P368, D417, E475, Y476, F478, K518, H527, T529, M531, N535, G539, P542, N545, Q546, A547, L549, I550, N552, G553, F558, A596, G603, A610, V615, Y622, C623, D624, I628, Y629, R632, N635, M641, A643, I644, T647, I648, T651, I652, K655, W656, D657, V658, H660, F662, L690 and combinations thereof. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_ES2804843TT3</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>ES2804843TT3</sourcerecordid><originalsourceid>FETCH-epo_espacenet_ES2804843TT33</originalsourceid><addsrcrecordid>eNrjZBAPSyzKTMwrSS1WSElVKMjPycxNLUosTuRhYE1LzClO5YXS3AyKbq4hzh66qQX58anFBYnJqXmpJfGuwUYWBiYWJsYhIcbGxKgBANSWIl0</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Variantes de polimerasa</title><source>esp@cenet</source><creator>MCGAW, Colin Alexander ; SUKO, Shawn ; SCHULTZ, Tyler O'Brien ; BIBILLO, Arkadiusz ; ECKERT, Barbara ; WUNDERLICH, David Daniel ; BOENITZ-DULAT, Mara ; THAI, Eileen ; LEDERMAN, Ilya ; ARNOLD, Cleoma Renetta ; WOERSDOERFER, Bigna ; SCHWAB, Charles Wayan ; AYER, Aruna</creator><creatorcontrib>MCGAW, Colin Alexander ; SUKO, Shawn ; SCHULTZ, Tyler O'Brien ; BIBILLO, Arkadiusz ; ECKERT, Barbara ; WUNDERLICH, David Daniel ; BOENITZ-DULAT, Mara ; THAI, Eileen ; LEDERMAN, Ilya ; ARNOLD, Cleoma Renetta ; WOERSDOERFER, Bigna ; SCHWAB, Charles Wayan ; AYER, Aruna</creatorcontrib><description>Una ADN polimerasa modificada que tiene una actividad ADN polimerasa que comprende una secuencia de aminoácidos que tiene al menos un 70 % de identidad de secuencia con respecto a la secuencia de aminoácidos como se expone en SEQ ID NO: 2, secuencia de aminoácidos que tiene una sustitución de acuerdo con S366 A/L y que opcionalmente incluye una o más sustituciones aminoacídicas seleccionadas del grupo que consiste en H223, N224, Y225, H227, I295, Y342, T343, I357, S360, L361, I363, S365Q, Y367, P368, D417, E475, Y476, F478, K518, H527, T529, M531, N535, G539, P542, N545, Q546, A547, L549, I550, N552, G553, F558, A596, G603, A610, V615, Y622, C623, D624, I628, Y629, R632, N635, M641, A643, I644, T647, I648, T651, I652, K655, W656, D657, V658, H660, F662, L690 y combinaciones de las mismas.
Described herein is a variant pol6 polymerase having at least one mutation selected from H223, N224, Y225, H227, I295, Y342, T343, I357, S360, L361, I363, S365, S366, Y367, P368, D417, E475, Y476, F478, K518, H527, T529, M531, N535, G539, P542, N545, Q546, A547, L549, I550, N552, G553, F558, A596, G603, A610, V615, Y622, C623, D624, I628, Y629, R632, N635, M641, A643, I644, T647, I648, T651, I652, K655, W656, D657, V658, H660, F662, L690 and combinations thereof.</description><language>spa</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210209&DB=EPODOC&CC=ES&NR=2804843T3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210209&DB=EPODOC&CC=ES&NR=2804843T3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MCGAW, Colin Alexander</creatorcontrib><creatorcontrib>SUKO, Shawn</creatorcontrib><creatorcontrib>SCHULTZ, Tyler O'Brien</creatorcontrib><creatorcontrib>BIBILLO, Arkadiusz</creatorcontrib><creatorcontrib>ECKERT, Barbara</creatorcontrib><creatorcontrib>WUNDERLICH, David Daniel</creatorcontrib><creatorcontrib>BOENITZ-DULAT, Mara</creatorcontrib><creatorcontrib>THAI, Eileen</creatorcontrib><creatorcontrib>LEDERMAN, Ilya</creatorcontrib><creatorcontrib>ARNOLD, Cleoma Renetta</creatorcontrib><creatorcontrib>WOERSDOERFER, Bigna</creatorcontrib><creatorcontrib>SCHWAB, Charles Wayan</creatorcontrib><creatorcontrib>AYER, Aruna</creatorcontrib><title>Variantes de polimerasa</title><description>Una ADN polimerasa modificada que tiene una actividad ADN polimerasa que comprende una secuencia de aminoácidos que tiene al menos un 70 % de identidad de secuencia con respecto a la secuencia de aminoácidos como se expone en SEQ ID NO: 2, secuencia de aminoácidos que tiene una sustitución de acuerdo con S366 A/L y que opcionalmente incluye una o más sustituciones aminoacídicas seleccionadas del grupo que consiste en H223, N224, Y225, H227, I295, Y342, T343, I357, S360, L361, I363, S365Q, Y367, P368, D417, E475, Y476, F478, K518, H527, T529, M531, N535, G539, P542, N545, Q546, A547, L549, I550, N552, G553, F558, A596, G603, A610, V615, Y622, C623, D624, I628, Y629, R632, N635, M641, A643, I644, T647, I648, T651, I652, K655, W656, D657, V658, H660, F662, L690 y combinaciones de las mismas.
Described herein is a variant pol6 polymerase having at least one mutation selected from H223, N224, Y225, H227, I295, Y342, T343, I357, S360, L361, I363, S365, S366, Y367, P368, D417, E475, Y476, F478, K518, H527, T529, M531, N535, G539, P542, N545, Q546, A547, L549, I550, N552, G553, F558, A596, G603, A610, V615, Y622, C623, D624, I628, Y629, R632, N635, M641, A643, I644, T647, I648, T651, I652, K655, W656, D657, V658, H660, F662, L690 and combinations thereof.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZBAPSyzKTMwrSS1WSElVKMjPycxNLUosTuRhYE1LzClO5YXS3AyKbq4hzh66qQX58anFBYnJqXmpJfGuwUYWBiYWJsYhIcbGxKgBANSWIl0</recordid><startdate>20210209</startdate><enddate>20210209</enddate><creator>MCGAW, Colin Alexander</creator><creator>SUKO, Shawn</creator><creator>SCHULTZ, Tyler O'Brien</creator><creator>BIBILLO, Arkadiusz</creator><creator>ECKERT, Barbara</creator><creator>WUNDERLICH, David Daniel</creator><creator>BOENITZ-DULAT, Mara</creator><creator>THAI, Eileen</creator><creator>LEDERMAN, Ilya</creator><creator>ARNOLD, Cleoma Renetta</creator><creator>WOERSDOERFER, Bigna</creator><creator>SCHWAB, Charles Wayan</creator><creator>AYER, Aruna</creator><scope>EVB</scope></search><sort><creationdate>20210209</creationdate><title>Variantes de polimerasa</title><author>MCGAW, Colin Alexander ; SUKO, Shawn ; SCHULTZ, Tyler O'Brien ; BIBILLO, Arkadiusz ; ECKERT, Barbara ; WUNDERLICH, David Daniel ; BOENITZ-DULAT, Mara ; THAI, Eileen ; LEDERMAN, Ilya ; ARNOLD, Cleoma Renetta ; WOERSDOERFER, Bigna ; SCHWAB, Charles Wayan ; AYER, Aruna</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_ES2804843TT33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>spa</language><creationdate>2021</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>MCGAW, Colin Alexander</creatorcontrib><creatorcontrib>SUKO, Shawn</creatorcontrib><creatorcontrib>SCHULTZ, Tyler O'Brien</creatorcontrib><creatorcontrib>BIBILLO, Arkadiusz</creatorcontrib><creatorcontrib>ECKERT, Barbara</creatorcontrib><creatorcontrib>WUNDERLICH, David Daniel</creatorcontrib><creatorcontrib>BOENITZ-DULAT, Mara</creatorcontrib><creatorcontrib>THAI, Eileen</creatorcontrib><creatorcontrib>LEDERMAN, Ilya</creatorcontrib><creatorcontrib>ARNOLD, Cleoma Renetta</creatorcontrib><creatorcontrib>WOERSDOERFER, Bigna</creatorcontrib><creatorcontrib>SCHWAB, Charles Wayan</creatorcontrib><creatorcontrib>AYER, Aruna</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MCGAW, Colin Alexander</au><au>SUKO, Shawn</au><au>SCHULTZ, Tyler O'Brien</au><au>BIBILLO, Arkadiusz</au><au>ECKERT, Barbara</au><au>WUNDERLICH, David Daniel</au><au>BOENITZ-DULAT, Mara</au><au>THAI, Eileen</au><au>LEDERMAN, Ilya</au><au>ARNOLD, Cleoma Renetta</au><au>WOERSDOERFER, Bigna</au><au>SCHWAB, Charles Wayan</au><au>AYER, Aruna</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Variantes de polimerasa</title><date>2021-02-09</date><risdate>2021</risdate><abstract>Una ADN polimerasa modificada que tiene una actividad ADN polimerasa que comprende una secuencia de aminoácidos que tiene al menos un 70 % de identidad de secuencia con respecto a la secuencia de aminoácidos como se expone en SEQ ID NO: 2, secuencia de aminoácidos que tiene una sustitución de acuerdo con S366 A/L y que opcionalmente incluye una o más sustituciones aminoacídicas seleccionadas del grupo que consiste en H223, N224, Y225, H227, I295, Y342, T343, I357, S360, L361, I363, S365Q, Y367, P368, D417, E475, Y476, F478, K518, H527, T529, M531, N535, G539, P542, N545, Q546, A547, L549, I550, N552, G553, F558, A596, G603, A610, V615, Y622, C623, D624, I628, Y629, R632, N635, M641, A643, I644, T647, I648, T651, I652, K655, W656, D657, V658, H660, F662, L690 y combinaciones de las mismas.
Described herein is a variant pol6 polymerase having at least one mutation selected from H223, N224, Y225, H227, I295, Y342, T343, I357, S360, L361, I363, S365, S366, Y367, P368, D417, E475, Y476, F478, K518, H527, T529, M531, N535, G539, P542, N545, Q546, A547, L549, I550, N552, G553, F558, A596, G603, A610, V615, Y622, C623, D624, I628, Y629, R632, N635, M641, A643, I644, T647, I648, T651, I652, K655, W656, D657, V658, H660, F662, L690 and combinations thereof.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | Variantes de polimerasa |
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