Modulación de la activación del inflamasoma de células supresoras derivadas de mieloides para el tratamiento de GvHD o tumor
Una pluralidad de celulas supresoras derivadas de mieloides (MDSC) deficientes en proteina similar a la mota asociada a la apoptosis que contiene una CARD (ASC) (MDSC deficientes en ASC) para usar en un metodo de tratamiento de un sujeto que tiene o esta en riesgo de tener la enfermedad injerto cont...
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| creator | TING, Jenny P. Y BLAZAR, Bruce R ZEISER, Robert MURRAY, Peter J MILLER, Jeff S KOEHN, Brent H |
| description | Una pluralidad de celulas supresoras derivadas de mieloides (MDSC) deficientes en proteina similar a la mota asociada a la apoptosis que contiene una CARD (ASC) (MDSC deficientes en ASC) para usar en un metodo de tratamiento de un sujeto que tiene o esta en riesgo de tener la enfermedad injerto contra huesped (GvHD), el metodo comprende: administrar al sujeto una pluralidad de MDSC deficientes en ASC.
In one aspect, a method of treating a subject having or at risk of having graft-versus-host disease (GvHD) generally includes administering to the subject a plurality of myeloid-derived suppressor cells (MDSCs) effective to ameliorate at least one symptom or clinical sign of graft-versus-host disease compared to a suitable control subject. In another aspect, a method of treating a tumor in a subject generally includes administering to the subject an anti-tumor therapy and co-administering to the subject an inflammasome inciting agent in an amount effective to increase inflammasome activation of MDSCs sufficiently to reduce suppressor function of the MDSCs. |
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In one aspect, a method of treating a subject having or at risk of having graft-versus-host disease (GvHD) generally includes administering to the subject a plurality of myeloid-derived suppressor cells (MDSCs) effective to ameliorate at least one symptom or clinical sign of graft-versus-host disease compared to a suitable control subject. In another aspect, a method of treating a tumor in a subject generally includes administering to the subject an anti-tumor therapy and co-administering to the subject an inflammasome inciting agent in an amount effective to increase inflammasome activation of MDSCs sufficiently to reduce suppressor function of the MDSCs.</description><language>spa</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20201026&DB=EPODOC&CC=ES&NR=2789574T3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20201026&DB=EPODOC&CC=ES&NR=2789574T3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>TING, Jenny P. Y</creatorcontrib><creatorcontrib>BLAZAR, Bruce R</creatorcontrib><creatorcontrib>ZEISER, Robert</creatorcontrib><creatorcontrib>MURRAY, Peter J</creatorcontrib><creatorcontrib>MILLER, Jeff S</creatorcontrib><creatorcontrib>KOEHN, Brent H</creatorcontrib><title>Modulación de la activación del inflamasoma de células supresoras derivadas de mieloides para el tratamiento de GvHD o tumor</title><description>Una pluralidad de celulas supresoras derivadas de mieloides (MDSC) deficientes en proteina similar a la mota asociada a la apoptosis que contiene una CARD (ASC) (MDSC deficientes en ASC) para usar en un metodo de tratamiento de un sujeto que tiene o esta en riesgo de tener la enfermedad injerto contra huesped (GvHD), el metodo comprende: administrar al sujeto una pluralidad de MDSC deficientes en ASC.
In one aspect, a method of treating a subject having or at risk of having graft-versus-host disease (GvHD) generally includes administering to the subject a plurality of myeloid-derived suppressor cells (MDSCs) effective to ameliorate at least one symptom or clinical sign of graft-versus-host disease compared to a suitable control subject. In another aspect, a method of treating a tumor in a subject generally includes administering to the subject an anti-tumor therapy and co-administering to the subject an inflammasome inciting agent in an amount effective to increase inflammasome activation of MDSCs sufficiently to reduce suppressor function of the MDSCs.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjDsOwjAQRNNQIOAOywFoCChQQyANFemjlb2RLNley5-0nIeaI-RiOAhRU83T6M3Mi8eNZdIo1PiyIAk0Aoqohl-jQdleo8HABidDjE-dFwFCcp4C-4ySfJ7ID4FRpFlJCuDQI-SH6DFirm3kSbgOzRkYYjLsl8WsRx1o9c1Fsb7U7anZkOOOgkNBlmJX37fV4bivdm1blv84bynTSuU</recordid><startdate>20201026</startdate><enddate>20201026</enddate><creator>TING, Jenny P. Y</creator><creator>BLAZAR, Bruce R</creator><creator>ZEISER, Robert</creator><creator>MURRAY, Peter J</creator><creator>MILLER, Jeff S</creator><creator>KOEHN, Brent H</creator><scope>EVB</scope></search><sort><creationdate>20201026</creationdate><title>Modulación de la activación del inflamasoma de células supresoras derivadas de mieloides para el tratamiento de GvHD o tumor</title><author>TING, Jenny P. Y ; BLAZAR, Bruce R ; ZEISER, Robert ; MURRAY, Peter J ; MILLER, Jeff S ; KOEHN, Brent H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_ES2789574TT33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>spa</language><creationdate>2020</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>TING, Jenny P. Y</creatorcontrib><creatorcontrib>BLAZAR, Bruce R</creatorcontrib><creatorcontrib>ZEISER, Robert</creatorcontrib><creatorcontrib>MURRAY, Peter J</creatorcontrib><creatorcontrib>MILLER, Jeff S</creatorcontrib><creatorcontrib>KOEHN, Brent H</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>TING, Jenny P. Y</au><au>BLAZAR, Bruce R</au><au>ZEISER, Robert</au><au>MURRAY, Peter J</au><au>MILLER, Jeff S</au><au>KOEHN, Brent H</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Modulación de la activación del inflamasoma de células supresoras derivadas de mieloides para el tratamiento de GvHD o tumor</title><date>2020-10-26</date><risdate>2020</risdate><abstract>Una pluralidad de celulas supresoras derivadas de mieloides (MDSC) deficientes en proteina similar a la mota asociada a la apoptosis que contiene una CARD (ASC) (MDSC deficientes en ASC) para usar en un metodo de tratamiento de un sujeto que tiene o esta en riesgo de tener la enfermedad injerto contra huesped (GvHD), el metodo comprende: administrar al sujeto una pluralidad de MDSC deficientes en ASC.
In one aspect, a method of treating a subject having or at risk of having graft-versus-host disease (GvHD) generally includes administering to the subject a plurality of myeloid-derived suppressor cells (MDSCs) effective to ameliorate at least one symptom or clinical sign of graft-versus-host disease compared to a suitable control subject. In another aspect, a method of treating a tumor in a subject generally includes administering to the subject an anti-tumor therapy and co-administering to the subject an inflammasome inciting agent in an amount effective to increase inflammasome activation of MDSCs sufficiently to reduce suppressor function of the MDSCs.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | Modulación de la activación del inflamasoma de células supresoras derivadas de mieloides para el tratamiento de GvHD o tumor |
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