Compuesto de pirrolopiridina tricíclico, e inhibidor de JAK
To provide a novel tricyclic pyrrolopyridine compound having a JAK inhibitory activity and useful for prevention, treatment and/or improvement of particularly autoimmune diseases, inflammatory diseases and allergic diseases. A novel tricyclic pyrrolopyridine compound represented by the formula (I),...
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| creator | WATANABE, Tsuneo HIDAKA, Yuuki NISHIMURA, Takuya KURIHARA, Kazunori YAMAMOTO, Akio TAKAHASHI, Keiji HAYASHI, Keishi KAMIYAMA, Toshihiko NAKAMURA, Takanori |
| description | To provide a novel tricyclic pyrrolopyridine compound having a JAK inhibitory activity and useful for prevention, treatment and/or improvement of particularly autoimmune diseases, inflammatory diseases and allergic diseases. A novel tricyclic pyrrolopyridine compound represented by the formula (I), a tautomer or pharmaceutically acceptable salt of the compound or a solvate thereof:
wherein the respective substituents are defined in detail in the specification, and R 1 is a C 1-6 alkyl group or the like, R 2 is a hydrogen atom or the like, R 3 is a hydrogen atom or the like, the ring A is C 3-11 cycloalkane or the like, L 1 is a C 1-6 alkylene group or the like, and R 4 is NR a R b or the like. |
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wherein the respective substituents are defined in detail in the specification, and R 1 is a C 1-6 alkyl group or the like, R 2 is a hydrogen atom or the like, R 3 is a hydrogen atom or the like, the ring A is C 3-11 cycloalkane or the like, L 1 is a C 1-6 alkylene group or the like, and R 4 is NR a R b or the like.</description><language>spa</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200421&DB=EPODOC&CC=ES&NR=2755130T3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76418</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200421&DB=EPODOC&CC=ES&NR=2755130T3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>WATANABE, Tsuneo</creatorcontrib><creatorcontrib>HIDAKA, Yuuki</creatorcontrib><creatorcontrib>NISHIMURA, Takuya</creatorcontrib><creatorcontrib>KURIHARA, Kazunori</creatorcontrib><creatorcontrib>YAMAMOTO, Akio</creatorcontrib><creatorcontrib>TAKAHASHI, Keiji</creatorcontrib><creatorcontrib>HAYASHI, Keishi</creatorcontrib><creatorcontrib>KAMIYAMA, Toshihiko</creatorcontrib><creatorcontrib>NAKAMURA, Takanori</creatorcontrib><title>Compuesto de pirrolopiridina tricíclico, e inhibidor de JAK</title><description>To provide a novel tricyclic pyrrolopyridine compound having a JAK inhibitory activity and useful for prevention, treatment and/or improvement of particularly autoimmune diseases, inflammatory diseases and allergic diseases. A novel tricyclic pyrrolopyridine compound represented by the formula (I), a tautomer or pharmaceutically acceptable salt of the compound or a solvate thereof:
wherein the respective substituents are defined in detail in the specification, and R 1 is a C 1-6 alkyl group or the like, R 2 is a hydrogen atom or the like, R 3 is a hydrogen atom or the like, the ring A is C 3-11 cycloalkane or the like, L 1 is a C 1-6 alkylene group or the like, and R 4 is NR a R b or the like.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLBxzs8tKE0tLslXSElVKMgsKsrPyQdSmSmZeYkKJUWZyYfXJudkJufrKKQqZOZlZCZlpuQXgdR6OXrzMLCmJeYUp_JCaW4GRTfXEGcP3dSC_PjU4oLE5NS81JJ412Ajc1NTQ2ODkBBjY2LUAAAf7DBm</recordid><startdate>20200421</startdate><enddate>20200421</enddate><creator>WATANABE, Tsuneo</creator><creator>HIDAKA, Yuuki</creator><creator>NISHIMURA, Takuya</creator><creator>KURIHARA, Kazunori</creator><creator>YAMAMOTO, Akio</creator><creator>TAKAHASHI, Keiji</creator><creator>HAYASHI, Keishi</creator><creator>KAMIYAMA, Toshihiko</creator><creator>NAKAMURA, Takanori</creator><scope>EVB</scope></search><sort><creationdate>20200421</creationdate><title>Compuesto de pirrolopiridina tricíclico, e inhibidor de JAK</title><author>WATANABE, Tsuneo ; HIDAKA, Yuuki ; NISHIMURA, Takuya ; KURIHARA, Kazunori ; YAMAMOTO, Akio ; TAKAHASHI, Keiji ; HAYASHI, Keishi ; KAMIYAMA, Toshihiko ; NAKAMURA, Takanori</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_ES2755130TT33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>spa</language><creationdate>2020</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>WATANABE, Tsuneo</creatorcontrib><creatorcontrib>HIDAKA, Yuuki</creatorcontrib><creatorcontrib>NISHIMURA, Takuya</creatorcontrib><creatorcontrib>KURIHARA, Kazunori</creatorcontrib><creatorcontrib>YAMAMOTO, Akio</creatorcontrib><creatorcontrib>TAKAHASHI, Keiji</creatorcontrib><creatorcontrib>HAYASHI, Keishi</creatorcontrib><creatorcontrib>KAMIYAMA, Toshihiko</creatorcontrib><creatorcontrib>NAKAMURA, Takanori</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>WATANABE, Tsuneo</au><au>HIDAKA, Yuuki</au><au>NISHIMURA, Takuya</au><au>KURIHARA, Kazunori</au><au>YAMAMOTO, Akio</au><au>TAKAHASHI, Keiji</au><au>HAYASHI, Keishi</au><au>KAMIYAMA, Toshihiko</au><au>NAKAMURA, Takanori</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Compuesto de pirrolopiridina tricíclico, e inhibidor de JAK</title><date>2020-04-21</date><risdate>2020</risdate><abstract>To provide a novel tricyclic pyrrolopyridine compound having a JAK inhibitory activity and useful for prevention, treatment and/or improvement of particularly autoimmune diseases, inflammatory diseases and allergic diseases. A novel tricyclic pyrrolopyridine compound represented by the formula (I), a tautomer or pharmaceutically acceptable salt of the compound or a solvate thereof:
wherein the respective substituents are defined in detail in the specification, and R 1 is a C 1-6 alkyl group or the like, R 2 is a hydrogen atom or the like, R 3 is a hydrogen atom or the like, the ring A is C 3-11 cycloalkane or the like, L 1 is a C 1-6 alkylene group or the like, and R 4 is NR a R b or the like.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Compuesto de pirrolopiridina tricíclico, e inhibidor de JAK |
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