COMPUESTOS ZWITTERIONICOS DE ACIDOS 2-FOSFOCOLINA CARBOXILICOS Y SU USO COMO AGENTES CITOTOXICOS
The present invention relates to zwitterions of saturated, monounsaturated, polyunsaturated and acid derivatives of 2-phosphocholine carboxylic acids with a structure described by general formula (1), and derivatives thereof, in which A is a carbonated chain with a number of carbon atoms between 4 a...
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Zusammenfassung: | The present invention relates to zwitterions of saturated, monounsaturated, polyunsaturated and acid derivatives of 2-phosphocholine carboxylic acids with a structure described by general formula (1), and derivatives thereof, in which A is a carbonated chain with a number of carbon atoms between 4 and 19 that is saturated, monounsaturated or polyunsaturated, mono or polyhydroxylated in different positions or non-hydroxylated, and (R) can be any atom or groups of atoms with a weight between 1 and 200 Da, wherein (R) is selected from: COOH, COOMe, COOEt, COOBut, COOBu, COOPri, COOBui, COOPr, COSEt, COSMe, COSPr, COSBu, COSPri,CSNR2R3, CONR2R3, CN and COOM, wherein M is a cation derived from an alkaline metal or alkaline earth metal, such as lithium, sodium, potassium, caesium, magnesium or calcium, R2 and R3 being able to be the same or different and representing an alkyl radical, which are pharmaceutically acceptable. The invention also relates to the use of the zwitterions against different types of carcinogenic cells. |
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