Composiciones farmacéuticas de paclitaxel, análogos de paclitaxel o conjugados de paclitaxel y métodos relacionados de preparación y uso

Una composición liofilizada que comprende: (a) ANG1005, en donde ANG1005 tiene la estructura:**Fórmula** (b) un agente de tonicidad opcional; (c) un agente de tamponamiento; (d) un agente de carga; (e) un agente solubilizante, en donde dicho agente solubilizante es un éster de polioxietileno de un á...

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Hauptverfasser: REGINA, Anthony, BELIVEAU, Richard, GAGNON, Catherine, CHE, Christian, CASTAIGNE, Jean-Paul, GABATHULER, Reinhard, DEMEULE, Michel
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creator REGINA, Anthony
BELIVEAU, Richard
GAGNON, Catherine
CHE, Christian
CASTAIGNE, Jean-Paul
GABATHULER, Reinhard
DEMEULE, Michel
description Una composición liofilizada que comprende: (a) ANG1005, en donde ANG1005 tiene la estructura:**Fórmula** (b) un agente de tonicidad opcional; (c) un agente de tamponamiento; (d) un agente de carga; (e) un agente solubilizante, en donde dicho agente solubilizante es un éster de polioxietileno de un ácido graso; y (f) del 0,2 al 10 % de DMSO. Pharmaceutical compositions useful for hydrophobic agents paclitaxel, paclitaxel analogs and conjugates thereof (e g ANG1005) which do not contain Cremophor™ The compositions further comprise an optional tonicity agent, a buffering agent a bulking agent and a solubilizing agent which is not Cremophor™ Methods of preparing said compositions and of said compositions in the treatment of cancer are also included.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Composiciones farmacéuticas de paclitaxel, análogos de paclitaxel o conjugados de paclitaxel y métodos relacionados de preparación y uso
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