Agentes perturbadores vasculares activados MMP
Un compuesto, o una de sus sales farmacéuticamente aceptables, que comprende un agente perturbador vascular (VDA) asociado con un péptido que comprende un sitio de escisión proteolítica de metaloproteinasa de matriz (MMP), en el que la VDA es un agente de unión anticancerígeno y tubulina, y el sitio...
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| creator | GILL, Jason ATKINSON, Jennifer BIBBY, Michael FALCONER, Robert Andrew LOADMAN, Paul PATTERSON, Laurence |
| description | Un compuesto, o una de sus sales farmacéuticamente aceptables, que comprende un agente perturbador vascular (VDA) asociado con un péptido que comprende un sitio de escisión proteolítica de metaloproteinasa de matriz (MMP), en el que la VDA es un agente de unión anticancerígeno y tubulina, y el sitio de escisión proteolítica de MMP comprende una secuencia de aminoácidos -Arg-Ser-Cit-Gly-Hof-P2'-Leu- en donde P2' es un aminoácido y no es tirosina.
The present invention relates to prodrugs of vascular disrupting agents comprising a vascular disrupting agent (VDA) associated with a MMP proteolytic cleavage site and to the use of such prodrugs in the targeted treatment of cancer. |
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The present invention relates to prodrugs of vascular disrupting agents comprising a vascular disrupting agent (VDA) associated with a MMP proteolytic cleavage site and to the use of such prodrugs in the targeted treatment of cancer.</description><language>spa</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190529&DB=EPODOC&CC=ES&NR=2714590T3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,781,886,25569,76552</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190529&DB=EPODOC&CC=ES&NR=2714590T3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>GILL, Jason</creatorcontrib><creatorcontrib>ATKINSON, Jennifer</creatorcontrib><creatorcontrib>BIBBY, Michael</creatorcontrib><creatorcontrib>FALCONER, Robert Andrew</creatorcontrib><creatorcontrib>LOADMAN, Paul</creatorcontrib><creatorcontrib>PATTERSON, Laurence</creatorcontrib><title>Agentes perturbadores vasculares activados MMP</title><description>Un compuesto, o una de sus sales farmacéuticamente aceptables, que comprende un agente perturbador vascular (VDA) asociado con un péptido que comprende un sitio de escisión proteolítica de metaloproteinasa de matriz (MMP), en el que la VDA es un agente de unión anticancerígeno y tubulina, y el sitio de escisión proteolítica de MMP comprende una secuencia de aminoácidos -Arg-Ser-Cit-Gly-Hof-P2'-Leu- en donde P2' es un aminoácido y no es tirosina.
The present invention relates to prodrugs of vascular disrupting agents comprising a vascular disrupting agent (VDA) associated with a MMP proteolytic cleavage site and to the use of such prodrugs in the targeted treatment of cancer.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2019</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNBzTE_NK0ktVihILSopLUpKTMkvAvLKEouTS3MSQczE5JLMMqBwsYKvbwAPA2taYk5xKi-U5mZQdHMNcfbQTS3Ij08tLkhMTs1LLYl3DTYyNzQxtTQICTE2JkYNACXKKzk</recordid><startdate>20190529</startdate><enddate>20190529</enddate><creator>GILL, Jason</creator><creator>ATKINSON, Jennifer</creator><creator>BIBBY, Michael</creator><creator>FALCONER, Robert Andrew</creator><creator>LOADMAN, Paul</creator><creator>PATTERSON, Laurence</creator><scope>EVB</scope></search><sort><creationdate>20190529</creationdate><title>Agentes perturbadores vasculares activados MMP</title><author>GILL, Jason ; ATKINSON, Jennifer ; BIBBY, Michael ; FALCONER, Robert Andrew ; LOADMAN, Paul ; PATTERSON, Laurence</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_ES2714590TT33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>spa</language><creationdate>2019</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>GILL, Jason</creatorcontrib><creatorcontrib>ATKINSON, Jennifer</creatorcontrib><creatorcontrib>BIBBY, Michael</creatorcontrib><creatorcontrib>FALCONER, Robert Andrew</creatorcontrib><creatorcontrib>LOADMAN, Paul</creatorcontrib><creatorcontrib>PATTERSON, Laurence</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>GILL, Jason</au><au>ATKINSON, Jennifer</au><au>BIBBY, Michael</au><au>FALCONER, Robert Andrew</au><au>LOADMAN, Paul</au><au>PATTERSON, Laurence</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Agentes perturbadores vasculares activados MMP</title><date>2019-05-29</date><risdate>2019</risdate><abstract>Un compuesto, o una de sus sales farmacéuticamente aceptables, que comprende un agente perturbador vascular (VDA) asociado con un péptido que comprende un sitio de escisión proteolítica de metaloproteinasa de matriz (MMP), en el que la VDA es un agente de unión anticancerígeno y tubulina, y el sitio de escisión proteolítica de MMP comprende una secuencia de aminoácidos -Arg-Ser-Cit-Gly-Hof-P2'-Leu- en donde P2' es un aminoácido y no es tirosina.
The present invention relates to prodrugs of vascular disrupting agents comprising a vascular disrupting agent (VDA) associated with a MMP proteolytic cleavage site and to the use of such prodrugs in the targeted treatment of cancer.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | Agentes perturbadores vasculares activados MMP |
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