Uso de un agente modificador de hormonas suprarrenales
Compuesto 4-[(5R)-6,7-dihidro-5H-pirrolo[1,2-c]imidazol-5-il]-3-fluoro-benzonitrilo que tiene la fórmula:**Fórmula** o una sal farmacéuticamente aceptable de dicho compuesto, para el uso en el tratamiento del síndrome de Cushing o la enfermedad de Cushing. The present invention relates to a method o...
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| creator | KSANDER, Gary SCHUMACHER, Christoph HU, Qi-Ying PAPILLON, Julien MONOVICH, Lauren G MEREDITH, Erik |
| description | Compuesto 4-[(5R)-6,7-dihidro-5H-pirrolo[1,2-c]imidazol-5-il]-3-fluoro-benzonitrilo que tiene la fórmula:**Fórmula** o una sal farmacéuticamente aceptable de dicho compuesto, para el uso en el tratamiento del síndrome de Cushing o la enfermedad de Cushing.
The present invention relates to a method of treating a disease or disorder characterised by increased stress hormone levels and/or decreased androgen hormone levels in a subject, comprising administering to the subject a therapeutically effective amount of a compound represented by formula (I):wherein n is 1 or 3; R is hydrogen or --C(O)N(R)(R) wherein Rand Rare independently--(C-C) alkyl, or --(C-C) alkyl-(C-C) aryl, wherein each of Rand Ris optionally substituted by --(C-C) alkoxy; RRand Rare independently hydrogen, halogen, cyano or --(C-C) aryl, wherein said --(C-C) aryl is optionally substituted by halogen, with the proviso that no more than one of RRand Ris hydrogen; and Rand Rare hydrogen; or a pharmaceutically acceptable salt thereof. |
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The present invention relates to a method of treating a disease or disorder characterised by increased stress hormone levels and/or decreased androgen hormone levels in a subject, comprising administering to the subject a therapeutically effective amount of a compound represented by formula (I):wherein n is 1 or 3; R is hydrogen or --C(O)N(R)(R) wherein Rand Rare independently--(C-C) alkyl, or --(C-C) alkyl-(C-C) aryl, wherein each of Rand Ris optionally substituted by --(C-C) alkoxy; RRand Rare independently hydrogen, halogen, cyano or --(C-C) aryl, wherein said --(C-C) aryl is optionally substituted by halogen, with the proviso that no more than one of RRand Ris hydrogen; and Rand Rare hydrogen; or a pharmaceutically acceptable salt thereof.</description><language>spa</language><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190404&DB=EPODOC&CC=ES&NR=2707596T3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190404&DB=EPODOC&CC=ES&NR=2707596T3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KSANDER, Gary</creatorcontrib><creatorcontrib>SCHUMACHER, Christoph</creatorcontrib><creatorcontrib>HU, Qi-Ying</creatorcontrib><creatorcontrib>PAPILLON, Julien</creatorcontrib><creatorcontrib>MONOVICH, Lauren G</creatorcontrib><creatorcontrib>MEREDITH, Erik</creatorcontrib><title>Uso de un agente modificador de hormonas suprarrenales</title><description>Compuesto 4-[(5R)-6,7-dihidro-5H-pirrolo[1,2-c]imidazol-5-il]-3-fluoro-benzonitrilo que tiene la fórmula:**Fórmula** o una sal farmacéuticamente aceptable de dicho compuesto, para el uso en el tratamiento del síndrome de Cushing o la enfermedad de Cushing.
The present invention relates to a method of treating a disease or disorder characterised by increased stress hormone levels and/or decreased androgen hormone levels in a subject, comprising administering to the subject a therapeutically effective amount of a compound represented by formula (I):wherein n is 1 or 3; R is hydrogen or --C(O)N(R)(R) wherein Rand Rare independently--(C-C) alkyl, or --(C-C) alkyl-(C-C) aryl, wherein each of Rand Ris optionally substituted by --(C-C) alkoxy; RRand Rare independently hydrogen, halogen, cyano or --(C-C) aryl, wherein said --(C-C) aryl is optionally substituted by halogen, with the proviso that no more than one of RRand Ris hydrogen; and Rand Rare hydrogen; or a pharmaceutically acceptable salt thereof.</description><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2019</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDALLc5XSElVKM1TSExPzStJVcjNT8lMy0xOTMkvAklk5Bfl5uclFisUlxYUJRYVpeYl5qQW8zCwpiXmFKfyQmluBkU31xBnD93Ugvz41OKCxOTUvNSSeNdgI3MDc1NLs5AQY2Ni1AAAmFwuFg</recordid><startdate>20190404</startdate><enddate>20190404</enddate><creator>KSANDER, Gary</creator><creator>SCHUMACHER, Christoph</creator><creator>HU, Qi-Ying</creator><creator>PAPILLON, Julien</creator><creator>MONOVICH, Lauren G</creator><creator>MEREDITH, Erik</creator><scope>EVB</scope></search><sort><creationdate>20190404</creationdate><title>Uso de un agente modificador de hormonas suprarrenales</title><author>KSANDER, Gary ; SCHUMACHER, Christoph ; HU, Qi-Ying ; PAPILLON, Julien ; MONOVICH, Lauren G ; MEREDITH, Erik</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_ES2707596TT33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>spa</language><creationdate>2019</creationdate><topic>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>KSANDER, Gary</creatorcontrib><creatorcontrib>SCHUMACHER, Christoph</creatorcontrib><creatorcontrib>HU, Qi-Ying</creatorcontrib><creatorcontrib>PAPILLON, Julien</creatorcontrib><creatorcontrib>MONOVICH, Lauren G</creatorcontrib><creatorcontrib>MEREDITH, Erik</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KSANDER, Gary</au><au>SCHUMACHER, Christoph</au><au>HU, Qi-Ying</au><au>PAPILLON, Julien</au><au>MONOVICH, Lauren G</au><au>MEREDITH, Erik</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Uso de un agente modificador de hormonas suprarrenales</title><date>2019-04-04</date><risdate>2019</risdate><abstract>Compuesto 4-[(5R)-6,7-dihidro-5H-pirrolo[1,2-c]imidazol-5-il]-3-fluoro-benzonitrilo que tiene la fórmula:**Fórmula** o una sal farmacéuticamente aceptable de dicho compuesto, para el uso en el tratamiento del síndrome de Cushing o la enfermedad de Cushing.
The present invention relates to a method of treating a disease or disorder characterised by increased stress hormone levels and/or decreased androgen hormone levels in a subject, comprising administering to the subject a therapeutically effective amount of a compound represented by formula (I):wherein n is 1 or 3; R is hydrogen or --C(O)N(R)(R) wherein Rand Rare independently--(C-C) alkyl, or --(C-C) alkyl-(C-C) aryl, wherein each of Rand Ris optionally substituted by --(C-C) alkoxy; RRand Rare independently hydrogen, halogen, cyano or --(C-C) aryl, wherein said --(C-C) aryl is optionally substituted by halogen, with the proviso that no more than one of RRand Ris hydrogen; and Rand Rare hydrogen; or a pharmaceutically acceptable salt thereof.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Uso de un agente modificador de hormonas suprarrenales |
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