Moduladores de FLAP
Un compuesto de fórmula (I)**Fórmula** en donde L es un enlace, -CH2-, -SO2-, -CH2-SO2-, -SO2-CH2-, -SO2-NR-, -SO2-NR-CH2-, -CH2-SO2-NR-, -NR-, -NR-SO2-, - NR-SO2-NR-, 20 -S-, -S-CH2-, -CH2-S-, -C(=O)-, -C(=O)-O-, -O-, -O-CH2-, -NR-C(=O)-, -NR-C(=O)-NR-, o -C(=O)-NR-, donde R es H, C1-2alquilo, C1-2...
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| creator | HAWRYLUK, Natalie A LIU, Jing KEITH, John M MCCLURE, Kelly J BACANI, Genesis M LEE-DUTRA, Alice ECCLES, Wendy HACK, Michael D SALES, Zachary S FITZGERALD, Anne E LEBSACK, Alec D JONES, William M GOLDBERG, Steven D PIPPEL, Daniel J KRAWCZUK, Paul MEDUNA, Steven P ROSEN, Mark D |
| description | Un compuesto de fórmula (I)**Fórmula** en donde L es un enlace, -CH2-, -SO2-, -CH2-SO2-, -SO2-CH2-, -SO2-NR-, -SO2-NR-CH2-, -CH2-SO2-NR-, -NR-, -NR-SO2-, - NR-SO2-NR-, 20 -S-, -S-CH2-, -CH2-S-, -C(=O)-, -C(=O)-O-, -O-, -O-CH2-, -NR-C(=O)-, -NR-C(=O)-NR-, o -C(=O)-NR-, donde R es H, C1-2alquilo, C1-2alquilo-OH o ciclopropil; R1 es H, o metil; R2 es H, ciano, halo, -SO2-CH3, 2-(trimetilsililo)etoxi, fenil, C1-6alquilo, heteroarilo, heterociclilo, C3-9cicloalquilo, siempre que R2 no sea H si L es un enlace, y en donde dicho fenil, C1-6alquilo, heteroarilo, heterociclilo o C3- 9cicloalquilo está opcional e independientemente sustituido con 1-4 sustituyentes seleccionados del grupo que consiste en: metil, etil, oxo, flúor, hidroxilo, ciano, amino, metoxi, terc-butoxi, acetil, ciclopropil, ciclobutil, ciclohexil, fenil, acetidin-1-il, acetidin-3-il, pirrolidin-1-il, 2,4-dihidro-3H-1,2,4-triazol-3-ona-4-il, 1H-imidazol-4-il, pirazin-2-il, pirimidin-2-il, 1,3-oxazolidin-2-ona-5-il, N-benzamida, benzo[d]imidazol-2(3H)-ona, 4-metilpiperazin-1-il, morfolin-4-il, CF3, -SO2-CH3, -C(=O)-ciclopropil, -SO2-ciclohexil, -NHCH3, -N(CH3)2, -NHAc, -NHCO2t-Bu, - CH2-NH2, -C(=O)-NH2, -C(=O)-N(etil)2, -NH-C(=O)-NH2, -NH-C(=O)-CH3, -C(=O)-(C1-C4alquilo), -C(=O)-OH, - C(=O)-NH (C1-C4alquilo)-(CH2)n-OH, y -(CH2)n-CN, en donde n es 1 o 2; V es CH, CR' o N, en donde R' es metil o F; W es CR" o N, en donde R" es H, F, hidroxilo, amino, CH3 o -O-CH3; el anillo A se selecciona del grupo que consiste en:**Fórmula** R3 es H, F, metil o -O-CH3; R3' es H o F; R4 es H, metil, ciano, amino, halo, -COOH, o -O-CH3; y R5 es H, metil, ciano o -CF3; o una sal farmacéuticamente aceptable del mismo.
The present invention relates to compounds of Formula (I),or a form thereof, wherein ring A, R, R, R, R', L, W, and V are as defined herein, useful as FLAP modulators. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention. |
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| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_ES2706399TT3</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>ES2706399TT3</sourcerecordid><originalsourceid>FETCH-epo_espacenet_ES2706399TT33</originalsourceid><addsrcrecordid>eNrjZBD2zU8pzUlMyS9KLVZISVVw83EM4GFgTUvMKU7lhdLcDIpuriHOHrqpBfnxqcUFicmpeakl8a7BRuYGZsaWliEhxsbEqAEA7p4gLw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Moduladores de FLAP</title><source>esp@cenet</source><creator>HAWRYLUK, Natalie A ; LIU, Jing ; KEITH, John M ; MCCLURE, Kelly J ; BACANI, Genesis M ; LEE-DUTRA, Alice ; ECCLES, Wendy ; HACK, Michael D ; SALES, Zachary S ; FITZGERALD, Anne E ; LEBSACK, Alec D ; JONES, William M ; GOLDBERG, Steven D ; PIPPEL, Daniel J ; KRAWCZUK, Paul ; MEDUNA, Steven P ; ROSEN, Mark D</creator><creatorcontrib>HAWRYLUK, Natalie A ; LIU, Jing ; KEITH, John M ; MCCLURE, Kelly J ; BACANI, Genesis M ; LEE-DUTRA, Alice ; ECCLES, Wendy ; HACK, Michael D ; SALES, Zachary S ; FITZGERALD, Anne E ; LEBSACK, Alec D ; JONES, William M ; GOLDBERG, Steven D ; PIPPEL, Daniel J ; KRAWCZUK, Paul ; MEDUNA, Steven P ; ROSEN, Mark D</creatorcontrib><description>Un compuesto de fórmula (I)**Fórmula** en donde L es un enlace, -CH2-, -SO2-, -CH2-SO2-, -SO2-CH2-, -SO2-NR-, -SO2-NR-CH2-, -CH2-SO2-NR-, -NR-, -NR-SO2-, - NR-SO2-NR-, 20 -S-, -S-CH2-, -CH2-S-, -C(=O)-, -C(=O)-O-, -O-, -O-CH2-, -NR-C(=O)-, -NR-C(=O)-NR-, o -C(=O)-NR-, donde R es H, C1-2alquilo, C1-2alquilo-OH o ciclopropil; R1 es H, o metil; R2 es H, ciano, halo, -SO2-CH3, 2-(trimetilsililo)etoxi, fenil, C1-6alquilo, heteroarilo, heterociclilo, C3-9cicloalquilo, siempre que R2 no sea H si L es un enlace, y en donde dicho fenil, C1-6alquilo, heteroarilo, heterociclilo o C3- 9cicloalquilo está opcional e independientemente sustituido con 1-4 sustituyentes seleccionados del grupo que consiste en: metil, etil, oxo, flúor, hidroxilo, ciano, amino, metoxi, terc-butoxi, acetil, ciclopropil, ciclobutil, ciclohexil, fenil, acetidin-1-il, acetidin-3-il, pirrolidin-1-il, 2,4-dihidro-3H-1,2,4-triazol-3-ona-4-il, 1H-imidazol-4-il, pirazin-2-il, pirimidin-2-il, 1,3-oxazolidin-2-ona-5-il, N-benzamida, benzo[d]imidazol-2(3H)-ona, 4-metilpiperazin-1-il, morfolin-4-il, CF3, -SO2-CH3, -C(=O)-ciclopropil, -SO2-ciclohexil, -NHCH3, -N(CH3)2, -NHAc, -NHCO2t-Bu, - CH2-NH2, -C(=O)-NH2, -C(=O)-N(etil)2, -NH-C(=O)-NH2, -NH-C(=O)-CH3, -C(=O)-(C1-C4alquilo), -C(=O)-OH, - C(=O)-NH (C1-C4alquilo)-(CH2)n-OH, y -(CH2)n-CN, en donde n es 1 o 2; V es CH, CR' o N, en donde R' es metil o F; W es CR" o N, en donde R" es H, F, hidroxilo, amino, CH3 o -O-CH3; el anillo A se selecciona del grupo que consiste en:**Fórmula** R3 es H, F, metil o -O-CH3; R3' es H o F; R4 es H, metil, ciano, amino, halo, -COOH, o -O-CH3; y R5 es H, metil, ciano o -CF3; o una sal farmacéuticamente aceptable del mismo.
The present invention relates to compounds of Formula (I),or a form thereof, wherein ring A, R, R, R, R', L, W, and V are as defined herein, useful as FLAP modulators. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.</description><language>spa</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190328&DB=EPODOC&CC=ES&NR=2706399T3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190328&DB=EPODOC&CC=ES&NR=2706399T3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HAWRYLUK, Natalie A</creatorcontrib><creatorcontrib>LIU, Jing</creatorcontrib><creatorcontrib>KEITH, John M</creatorcontrib><creatorcontrib>MCCLURE, Kelly J</creatorcontrib><creatorcontrib>BACANI, Genesis M</creatorcontrib><creatorcontrib>LEE-DUTRA, Alice</creatorcontrib><creatorcontrib>ECCLES, Wendy</creatorcontrib><creatorcontrib>HACK, Michael D</creatorcontrib><creatorcontrib>SALES, Zachary S</creatorcontrib><creatorcontrib>FITZGERALD, Anne E</creatorcontrib><creatorcontrib>LEBSACK, Alec D</creatorcontrib><creatorcontrib>JONES, William M</creatorcontrib><creatorcontrib>GOLDBERG, Steven D</creatorcontrib><creatorcontrib>PIPPEL, Daniel J</creatorcontrib><creatorcontrib>KRAWCZUK, Paul</creatorcontrib><creatorcontrib>MEDUNA, Steven P</creatorcontrib><creatorcontrib>ROSEN, Mark D</creatorcontrib><title>Moduladores de FLAP</title><description>Un compuesto de fórmula (I)**Fórmula** en donde L es un enlace, -CH2-, -SO2-, -CH2-SO2-, -SO2-CH2-, -SO2-NR-, -SO2-NR-CH2-, -CH2-SO2-NR-, -NR-, -NR-SO2-, - NR-SO2-NR-, 20 -S-, -S-CH2-, -CH2-S-, -C(=O)-, -C(=O)-O-, -O-, -O-CH2-, -NR-C(=O)-, -NR-C(=O)-NR-, o -C(=O)-NR-, donde R es H, C1-2alquilo, C1-2alquilo-OH o ciclopropil; R1 es H, o metil; R2 es H, ciano, halo, -SO2-CH3, 2-(trimetilsililo)etoxi, fenil, C1-6alquilo, heteroarilo, heterociclilo, C3-9cicloalquilo, siempre que R2 no sea H si L es un enlace, y en donde dicho fenil, C1-6alquilo, heteroarilo, heterociclilo o C3- 9cicloalquilo está opcional e independientemente sustituido con 1-4 sustituyentes seleccionados del grupo que consiste en: metil, etil, oxo, flúor, hidroxilo, ciano, amino, metoxi, terc-butoxi, acetil, ciclopropil, ciclobutil, ciclohexil, fenil, acetidin-1-il, acetidin-3-il, pirrolidin-1-il, 2,4-dihidro-3H-1,2,4-triazol-3-ona-4-il, 1H-imidazol-4-il, pirazin-2-il, pirimidin-2-il, 1,3-oxazolidin-2-ona-5-il, N-benzamida, benzo[d]imidazol-2(3H)-ona, 4-metilpiperazin-1-il, morfolin-4-il, CF3, -SO2-CH3, -C(=O)-ciclopropil, -SO2-ciclohexil, -NHCH3, -N(CH3)2, -NHAc, -NHCO2t-Bu, - CH2-NH2, -C(=O)-NH2, -C(=O)-N(etil)2, -NH-C(=O)-NH2, -NH-C(=O)-CH3, -C(=O)-(C1-C4alquilo), -C(=O)-OH, - C(=O)-NH (C1-C4alquilo)-(CH2)n-OH, y -(CH2)n-CN, en donde n es 1 o 2; V es CH, CR' o N, en donde R' es metil o F; W es CR" o N, en donde R" es H, F, hidroxilo, amino, CH3 o -O-CH3; el anillo A se selecciona del grupo que consiste en:**Fórmula** R3 es H, F, metil o -O-CH3; R3' es H o F; R4 es H, metil, ciano, amino, halo, -COOH, o -O-CH3; y R5 es H, metil, ciano o -CF3; o una sal farmacéuticamente aceptable del mismo.
The present invention relates to compounds of Formula (I),or a form thereof, wherein ring A, R, R, R, R', L, W, and V are as defined herein, useful as FLAP modulators. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2019</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZBD2zU8pzUlMyS9KLVZISVVw83EM4GFgTUvMKU7lhdLcDIpuriHOHrqpBfnxqcUFicmpeakl8a7BRuYGZsaWliEhxsbEqAEA7p4gLw</recordid><startdate>20190328</startdate><enddate>20190328</enddate><creator>HAWRYLUK, Natalie A</creator><creator>LIU, Jing</creator><creator>KEITH, John M</creator><creator>MCCLURE, Kelly J</creator><creator>BACANI, Genesis M</creator><creator>LEE-DUTRA, Alice</creator><creator>ECCLES, Wendy</creator><creator>HACK, Michael D</creator><creator>SALES, Zachary S</creator><creator>FITZGERALD, Anne E</creator><creator>LEBSACK, Alec D</creator><creator>JONES, William M</creator><creator>GOLDBERG, Steven D</creator><creator>PIPPEL, Daniel J</creator><creator>KRAWCZUK, Paul</creator><creator>MEDUNA, Steven P</creator><creator>ROSEN, Mark D</creator><scope>EVB</scope></search><sort><creationdate>20190328</creationdate><title>Moduladores de FLAP</title><author>HAWRYLUK, Natalie A ; LIU, Jing ; KEITH, John M ; MCCLURE, Kelly J ; BACANI, Genesis M ; LEE-DUTRA, Alice ; ECCLES, Wendy ; HACK, Michael D ; SALES, Zachary S ; FITZGERALD, Anne E ; LEBSACK, Alec D ; JONES, William M ; GOLDBERG, Steven D ; PIPPEL, Daniel J ; KRAWCZUK, Paul ; MEDUNA, Steven P ; ROSEN, Mark D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_ES2706399TT33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>spa</language><creationdate>2019</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>HAWRYLUK, Natalie A</creatorcontrib><creatorcontrib>LIU, Jing</creatorcontrib><creatorcontrib>KEITH, John M</creatorcontrib><creatorcontrib>MCCLURE, Kelly J</creatorcontrib><creatorcontrib>BACANI, Genesis M</creatorcontrib><creatorcontrib>LEE-DUTRA, Alice</creatorcontrib><creatorcontrib>ECCLES, Wendy</creatorcontrib><creatorcontrib>HACK, Michael D</creatorcontrib><creatorcontrib>SALES, Zachary S</creatorcontrib><creatorcontrib>FITZGERALD, Anne E</creatorcontrib><creatorcontrib>LEBSACK, Alec D</creatorcontrib><creatorcontrib>JONES, William M</creatorcontrib><creatorcontrib>GOLDBERG, Steven D</creatorcontrib><creatorcontrib>PIPPEL, Daniel J</creatorcontrib><creatorcontrib>KRAWCZUK, Paul</creatorcontrib><creatorcontrib>MEDUNA, Steven P</creatorcontrib><creatorcontrib>ROSEN, Mark D</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HAWRYLUK, Natalie A</au><au>LIU, Jing</au><au>KEITH, John M</au><au>MCCLURE, Kelly J</au><au>BACANI, Genesis M</au><au>LEE-DUTRA, Alice</au><au>ECCLES, Wendy</au><au>HACK, Michael D</au><au>SALES, Zachary S</au><au>FITZGERALD, Anne E</au><au>LEBSACK, Alec D</au><au>JONES, William M</au><au>GOLDBERG, Steven D</au><au>PIPPEL, Daniel J</au><au>KRAWCZUK, Paul</au><au>MEDUNA, Steven P</au><au>ROSEN, Mark D</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Moduladores de FLAP</title><date>2019-03-28</date><risdate>2019</risdate><abstract>Un compuesto de fórmula (I)**Fórmula** en donde L es un enlace, -CH2-, -SO2-, -CH2-SO2-, -SO2-CH2-, -SO2-NR-, -SO2-NR-CH2-, -CH2-SO2-NR-, -NR-, -NR-SO2-, - NR-SO2-NR-, 20 -S-, -S-CH2-, -CH2-S-, -C(=O)-, -C(=O)-O-, -O-, -O-CH2-, -NR-C(=O)-, -NR-C(=O)-NR-, o -C(=O)-NR-, donde R es H, C1-2alquilo, C1-2alquilo-OH o ciclopropil; R1 es H, o metil; R2 es H, ciano, halo, -SO2-CH3, 2-(trimetilsililo)etoxi, fenil, C1-6alquilo, heteroarilo, heterociclilo, C3-9cicloalquilo, siempre que R2 no sea H si L es un enlace, y en donde dicho fenil, C1-6alquilo, heteroarilo, heterociclilo o C3- 9cicloalquilo está opcional e independientemente sustituido con 1-4 sustituyentes seleccionados del grupo que consiste en: metil, etil, oxo, flúor, hidroxilo, ciano, amino, metoxi, terc-butoxi, acetil, ciclopropil, ciclobutil, ciclohexil, fenil, acetidin-1-il, acetidin-3-il, pirrolidin-1-il, 2,4-dihidro-3H-1,2,4-triazol-3-ona-4-il, 1H-imidazol-4-il, pirazin-2-il, pirimidin-2-il, 1,3-oxazolidin-2-ona-5-il, N-benzamida, benzo[d]imidazol-2(3H)-ona, 4-metilpiperazin-1-il, morfolin-4-il, CF3, -SO2-CH3, -C(=O)-ciclopropil, -SO2-ciclohexil, -NHCH3, -N(CH3)2, -NHAc, -NHCO2t-Bu, - CH2-NH2, -C(=O)-NH2, -C(=O)-N(etil)2, -NH-C(=O)-NH2, -NH-C(=O)-CH3, -C(=O)-(C1-C4alquilo), -C(=O)-OH, - C(=O)-NH (C1-C4alquilo)-(CH2)n-OH, y -(CH2)n-CN, en donde n es 1 o 2; V es CH, CR' o N, en donde R' es metil o F; W es CR" o N, en donde R" es H, F, hidroxilo, amino, CH3 o -O-CH3; el anillo A se selecciona del grupo que consiste en:**Fórmula** R3 es H, F, metil o -O-CH3; R3' es H o F; R4 es H, metil, ciano, amino, halo, -COOH, o -O-CH3; y R5 es H, metil, ciano o -CF3; o una sal farmacéuticamente aceptable del mismo.
The present invention relates to compounds of Formula (I),or a form thereof, wherein ring A, R, R, R, R', L, W, and V are as defined herein, useful as FLAP modulators. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.</abstract><oa>free_for_read</oa></addata></record> |
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| title | Moduladores de FLAP |
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