Derivados de aza-epoxi-guayano y tratamiento del cáncer
Compuesto de fórmula (I) o fórmula (II):**Fórmula** o un epímero del mismo, en las que R1 es isopropilo o isopropilenilo, R2 y R3 son independientemente alquilo C1-C6, R4 es arilo C6-C10 o cicloalquilo C3-C8, en el que el arilo está opcionalmente sustituido con alquilo C1-C6, hidroxialquilo C1-C6, a...
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| creator | RAMOS, Joe William BEUTLER, John A PEER, Cody John SULZMAIER, Florian J FIGG, William D CHAIN, William J FASH, David LI, Zhenwu |
| description | Compuesto de fórmula (I) o fórmula (II):**Fórmula** o un epímero del mismo, en las que R1 es isopropilo o isopropilenilo, R2 y R3 son independientemente alquilo C1-C6, R4 es arilo C6-C10 o cicloalquilo C3-C8, en el que el arilo está opcionalmente sustituido con alquilo C1-C6, hidroxialquilo C1-C6, alcoxilo C1-C6, halo o nitro, R5 es hidrógeno o alquilo C1-C6, y R6 es alquilo C1-C6, hidroxialquilo C1-C6 o fluoroalquilo C1-C6.
Disclosed is a compound of formula (I) or formula (II): (Formulas should be inserted here) wherein R1-R6 are as defined herein. Also disclosed are a pharmaceutical composition comprising such a compound and a method of treating or preventing cancer in a mammal in need thereof, comprising administering to the mammal a compound of formula (I) or formula (II). |
| format | Patent |
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Disclosed is a compound of formula (I) or formula (II): (Formulas should be inserted here) wherein R1-R6 are as defined herein. Also disclosed are a pharmaceutical composition comprising such a compound and a method of treating or preventing cancer in a mammal in need thereof, comprising administering to the mammal a compound of formula (I) or formula (II).</description><language>spa</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2018</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180920&DB=EPODOC&CC=ES&NR=2682368T3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180920&DB=EPODOC&CC=ES&NR=2682368T3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>RAMOS, Joe William</creatorcontrib><creatorcontrib>BEUTLER, John A</creatorcontrib><creatorcontrib>PEER, Cody John</creatorcontrib><creatorcontrib>SULZMAIER, Florian J</creatorcontrib><creatorcontrib>FIGG, William D</creatorcontrib><creatorcontrib>CHAIN, William J</creatorcontrib><creatorcontrib>FASH, David</creatorcontrib><creatorcontrib>LI, Zhenwu</creatorcontrib><title>Derivados de aza-epoxi-guayano y tratamiento del cáncer</title><description>Compuesto de fórmula (I) o fórmula (II):**Fórmula** o un epímero del mismo, en las que R1 es isopropilo o isopropilenilo, R2 y R3 son independientemente alquilo C1-C6, R4 es arilo C6-C10 o cicloalquilo C3-C8, en el que el arilo está opcionalmente sustituido con alquilo C1-C6, hidroxialquilo C1-C6, alcoxilo C1-C6, halo o nitro, R5 es hidrógeno o alquilo C1-C6, y R6 es alquilo C1-C6, hidroxialquilo C1-C6 o fluoroalquilo C1-C6.
Disclosed is a compound of formula (I) or formula (II): (Formulas should be inserted here) wherein R1-R6 are as defined herein. Also disclosed are a pharmaceutical composition comprising such a compound and a method of treating or preventing cancer in a mammal in need thereof, comprising administering to the mammal a compound of formula (I) or formula (II).</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2018</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLBwSS3KLEtMyS9WSElVSKxK1E0tyK_I1E0vTaxMzMtXqFQoKUosSczNTM0ryQcqyVFIPrwwLzm1iIeBNS0xpziVF0pzMyi6uYY4e4D0x6cWFyQmp-allsS7BhuZWRgZm1mEhBgbE6MGADqcL0U</recordid><startdate>20180920</startdate><enddate>20180920</enddate><creator>RAMOS, Joe William</creator><creator>BEUTLER, John A</creator><creator>PEER, Cody John</creator><creator>SULZMAIER, Florian J</creator><creator>FIGG, William D</creator><creator>CHAIN, William J</creator><creator>FASH, David</creator><creator>LI, Zhenwu</creator><scope>EVB</scope></search><sort><creationdate>20180920</creationdate><title>Derivados de aza-epoxi-guayano y tratamiento del cáncer</title><author>RAMOS, Joe William ; BEUTLER, John A ; PEER, Cody John ; SULZMAIER, Florian J ; FIGG, William D ; CHAIN, William J ; FASH, David ; LI, Zhenwu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_ES2682368TT33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>spa</language><creationdate>2018</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>RAMOS, Joe William</creatorcontrib><creatorcontrib>BEUTLER, John A</creatorcontrib><creatorcontrib>PEER, Cody John</creatorcontrib><creatorcontrib>SULZMAIER, Florian J</creatorcontrib><creatorcontrib>FIGG, William D</creatorcontrib><creatorcontrib>CHAIN, William J</creatorcontrib><creatorcontrib>FASH, David</creatorcontrib><creatorcontrib>LI, Zhenwu</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>RAMOS, Joe William</au><au>BEUTLER, John A</au><au>PEER, Cody John</au><au>SULZMAIER, Florian J</au><au>FIGG, William D</au><au>CHAIN, William J</au><au>FASH, David</au><au>LI, Zhenwu</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Derivados de aza-epoxi-guayano y tratamiento del cáncer</title><date>2018-09-20</date><risdate>2018</risdate><abstract>Compuesto de fórmula (I) o fórmula (II):**Fórmula** o un epímero del mismo, en las que R1 es isopropilo o isopropilenilo, R2 y R3 son independientemente alquilo C1-C6, R4 es arilo C6-C10 o cicloalquilo C3-C8, en el que el arilo está opcionalmente sustituido con alquilo C1-C6, hidroxialquilo C1-C6, alcoxilo C1-C6, halo o nitro, R5 es hidrógeno o alquilo C1-C6, y R6 es alquilo C1-C6, hidroxialquilo C1-C6 o fluoroalquilo C1-C6.
Disclosed is a compound of formula (I) or formula (II): (Formulas should be inserted here) wherein R1-R6 are as defined herein. Also disclosed are a pharmaceutical composition comprising such a compound and a method of treating or preventing cancer in a mammal in need thereof, comprising administering to the mammal a compound of formula (I) or formula (II).</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Derivados de aza-epoxi-guayano y tratamiento del cáncer |
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