Forma cristalina de abacavir que está esencialmente libre de disolvente
Forma cristalina de abacavir que está esencialmente libre de disolvente y libre de solvatación de formula (I),**Fórmula** caracterizada por presentar un difractograma de rayos X en polvo que comprende picos característicos a aproximadamente 8,0; 10,0; 10,2; 10,6; 11,9; 12,4, 12,7, 15,0, 16,1, 16,6,...
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| creator | Solà i Carandell, Lluís Benet-Buchholz, Jordi Berenguer Maimó, Ramón Bartra Sanmartí, Martí |
| description | Forma cristalina de abacavir que está esencialmente libre de disolvente y libre de solvatación de formula (I),**Fórmula** caracterizada por presentar un difractograma de rayos X en polvo que comprende picos característicos a aproximadamente 8,0; 10,0; 10,2; 10,6; 11,9; 12,4, 12,7, 15,0, 16,1, 16,6, 19,5, 20,2, 20,6, 20,7, 21,9, 23,0, 23,9, y 25,0 grados de 2 theta usando una radiación CuKα1 (λ >= 1.54060 Å); y por tener un grado de pureza mayor del 99%.
Crystalline form of abacavir that is essentially free of solvent of formula (I), in particular crystalline Form I, and its preparation process which comprises the following steps: a) crystallizing abacavir from a solution of said compound in a (C 1 -C 4 )-alcohol, dichloromethane, acetonitrile/water, or mixtures thereof; b) isolating the crystalline form of abacavir that appears in the prior step; and c) removing the solvent from the crystalline form of abacavir thus obtained. Crystalline Form I can also be obtained by dispersion of abacavir in acetonitrile. The crystalline form of abacavir that is essentially free of solvent is useful for the preparation of pharmaceutical compositions for use in the treatment and/or prophylaxis of HIV infections. |
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Crystalline form of abacavir that is essentially free of solvent of formula (I), in particular crystalline Form I, and its preparation process which comprises the following steps: a) crystallizing abacavir from a solution of said compound in a (C 1 -C 4 )-alcohol, dichloromethane, acetonitrile/water, or mixtures thereof; b) isolating the crystalline form of abacavir that appears in the prior step; and c) removing the solvent from the crystalline form of abacavir thus obtained. Crystalline Form I can also be obtained by dispersion of abacavir in acetonitrile. The crystalline form of abacavir that is essentially free of solvent is useful for the preparation of pharmaceutical compositions for use in the treatment and/or prophylaxis of HIV infections.</description><language>spa</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2018</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180601&DB=EPODOC&CC=ES&NR=2670802T3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180601&DB=EPODOC&CC=ES&NR=2670802T3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Solà i Carandell, Lluís</creatorcontrib><creatorcontrib>Benet-Buchholz, Jordi</creatorcontrib><creatorcontrib>Berenguer Maimó, Ramón</creatorcontrib><creatorcontrib>Bartra Sanmartí, Martí</creatorcontrib><title>Forma cristalina de abacavir que está esencialmente libre de disolvente</title><description>Forma cristalina de abacavir que está esencialmente libre de disolvente y libre de solvatación de formula (I),**Fórmula** caracterizada por presentar un difractograma de rayos X en polvo que comprende picos característicos a aproximadamente 8,0; 10,0; 10,2; 10,6; 11,9; 12,4, 12,7, 15,0, 16,1, 16,6, 19,5, 20,2, 20,6, 20,7, 21,9, 23,0, 23,9, y 25,0 grados de 2 theta usando una radiación CuKα1 (λ >= 1.54060 Å); y por tener un grado de pureza mayor del 99%.
Crystalline form of abacavir that is essentially free of solvent of formula (I), in particular crystalline Form I, and its preparation process which comprises the following steps: a) crystallizing abacavir from a solution of said compound in a (C 1 -C 4 )-alcohol, dichloromethane, acetonitrile/water, or mixtures thereof; b) isolating the crystalline form of abacavir that appears in the prior step; and c) removing the solvent from the crystalline form of abacavir thus obtained. Crystalline Form I can also be obtained by dispersion of abacavir in acetonitrile. The crystalline form of abacavir that is essentially free of solvent is useful for the preparation of pharmaceutical compositions for use in the treatment and/or prophylaxis of HIV infections.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2018</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPBwyy_KTVRILsosLknMycxLVEhJVUhMSkxOLMssUigsTVVILS45vBBIpuYlZybm5KbmlaQq5GQmFaWCVKZkFufnlIHEeBhY0xJzilN5oTQ3g6Kba4izh25qQX58anFBYnJqXmpJvGuwkZm5gYWBUUiIsTExagDtTjVQ</recordid><startdate>20180601</startdate><enddate>20180601</enddate><creator>Solà i Carandell, Lluís</creator><creator>Benet-Buchholz, Jordi</creator><creator>Berenguer Maimó, Ramón</creator><creator>Bartra Sanmartí, Martí</creator><scope>EVB</scope></search><sort><creationdate>20180601</creationdate><title>Forma cristalina de abacavir que está esencialmente libre de disolvente</title><author>Solà i Carandell, Lluís ; Benet-Buchholz, Jordi ; Berenguer Maimó, Ramón ; Bartra Sanmartí, Martí</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_ES2670802TT33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>spa</language><creationdate>2018</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>Solà i Carandell, Lluís</creatorcontrib><creatorcontrib>Benet-Buchholz, Jordi</creatorcontrib><creatorcontrib>Berenguer Maimó, Ramón</creatorcontrib><creatorcontrib>Bartra Sanmartí, Martí</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Solà i Carandell, Lluís</au><au>Benet-Buchholz, Jordi</au><au>Berenguer Maimó, Ramón</au><au>Bartra Sanmartí, Martí</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Forma cristalina de abacavir que está esencialmente libre de disolvente</title><date>2018-06-01</date><risdate>2018</risdate><abstract>Forma cristalina de abacavir que está esencialmente libre de disolvente y libre de solvatación de formula (I),**Fórmula** caracterizada por presentar un difractograma de rayos X en polvo que comprende picos característicos a aproximadamente 8,0; 10,0; 10,2; 10,6; 11,9; 12,4, 12,7, 15,0, 16,1, 16,6, 19,5, 20,2, 20,6, 20,7, 21,9, 23,0, 23,9, y 25,0 grados de 2 theta usando una radiación CuKα1 (λ >= 1.54060 Å); y por tener un grado de pureza mayor del 99%.
Crystalline form of abacavir that is essentially free of solvent of formula (I), in particular crystalline Form I, and its preparation process which comprises the following steps: a) crystallizing abacavir from a solution of said compound in a (C 1 -C 4 )-alcohol, dichloromethane, acetonitrile/water, or mixtures thereof; b) isolating the crystalline form of abacavir that appears in the prior step; and c) removing the solvent from the crystalline form of abacavir thus obtained. Crystalline Form I can also be obtained by dispersion of abacavir in acetonitrile. The crystalline form of abacavir that is essentially free of solvent is useful for the preparation of pharmaceutical compositions for use in the treatment and/or prophylaxis of HIV infections.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Forma cristalina de abacavir que está esencialmente libre de disolvente |
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