Producción de factor de coagulación IX con patrón de glucosilación mejorado
An improved system for large scale production of antibodies in cell culture is provided. In accordance with the present invention, cells expressing an antibody are grown in media that contain manganese at a concentration of between approximately 10 and 600 nM. The use of such a system allows product...
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| creator | Koza, Stephan M Lasko, Daniel R |
| description | An improved system for large scale production of antibodies in cell culture is provided. In accordance with the present invention, cells expressing an antibody are grown in media that contain manganese at a concentration of between approximately 10 and 600 nM. The use of such a system allows production of an antibody with an increased glycosylation pattern and/or a glycosylation pattern that more accurately reflects the glycosylation pattern of the naturally occurring antibody. An antibody expressed in accordance with the present invention may be advantageously used in the preparation of pharmaceutical compositions. |
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In accordance with the present invention, cells expressing an antibody are grown in media that contain manganese at a concentration of between approximately 10 and 600 nM. The use of such a system allows production of an antibody with an increased glycosylation pattern and/or a glycosylation pattern that more accurately reflects the glycosylation pattern of the naturally occurring antibody. An antibody expressed in accordance with the present invention may be advantageously used in the preparation of pharmaceutical compositions.</description><language>spa</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2018</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180530&DB=EPODOC&CC=ES&NR=2668212T9$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25562,76317</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180530&DB=EPODOC&CC=ES&NR=2668212T9$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Koza, Stephan M</creatorcontrib><creatorcontrib>Lasko, Daniel R</creatorcontrib><title>Producción de factor de coagulación IX con patrón de glucosilación mejorado</title><description>An improved system for large scale production of antibodies in cell culture is provided. 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An antibody expressed in accordance with the present invention may be advantageously used in the preparation of pharmaceutical compositions.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2018</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPAPKMpPKU1Ozjy8OU8hJVUhLTG5JL8IxErOT0wvzUmEyHhGAPl5CgWJJUVQhek5pcn5xZkwBbmpWflFiSn5PAysaYk5xam8UJqbQdHNNcTZQze1ID8-tbggMTk1L7Uk3jXYyMzMwsjQKCTE0pgYNQB9Nzm9</recordid><startdate>20180530</startdate><enddate>20180530</enddate><creator>Koza, Stephan M</creator><creator>Lasko, Daniel R</creator><scope>EVB</scope></search><sort><creationdate>20180530</creationdate><title>Producción de factor de coagulación IX con patrón de glucosilación mejorado</title><author>Koza, Stephan M ; Lasko, Daniel R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_ES2668212TT93</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>spa</language><creationdate>2018</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>Koza, Stephan M</creatorcontrib><creatorcontrib>Lasko, Daniel R</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Koza, Stephan M</au><au>Lasko, Daniel R</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Producción de factor de coagulación IX con patrón de glucosilación mejorado</title><date>2018-05-30</date><risdate>2018</risdate><abstract>An improved system for large scale production of antibodies in cell culture is provided. In accordance with the present invention, cells expressing an antibody are grown in media that contain manganese at a concentration of between approximately 10 and 600 nM. The use of such a system allows production of an antibody with an increased glycosylation pattern and/or a glycosylation pattern that more accurately reflects the glycosylation pattern of the naturally occurring antibody. An antibody expressed in accordance with the present invention may be advantageously used in the preparation of pharmaceutical compositions.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | Producción de factor de coagulación IX con patrón de glucosilación mejorado |
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