Procedimiento de preparación de derivados 4''-sustituidos de 9-desoxo-9a-aza-9a-homoeritromicina A
Un procedimiento de preparación de un compuesto de fórmula 1a**Fórmula** o una sal farmacéuticamente aceptable del mismo, haciendo reaccionar un compuesto de fórmula 2**Fórmula** con n-propilamina en un disolvente orgánico que comprende isopropanol; en el que la reacción se lleva a cabo a una temper...
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| creator | Hammen, Philip Dietrich Lehner, Richard Shelton Tucker, John Lloyd Negri, Joanna Teresa Wei, Lulin |
| description | Un procedimiento de preparación de un compuesto de fórmula 1a**Fórmula** o una sal farmacéuticamente aceptable del mismo, haciendo reaccionar un compuesto de fórmula 2**Fórmula** con n-propilamina en un disolvente orgánico que comprende isopropanol; en el que la reacción se lleva a cabo a una temperatura de al menos 40 °C.
The invention relates to processes for preparing compounds of formula 1 wherein R is as defined herein, and to pharmaceutically acceptable salts thereof, as well as intermediates useful in such processes. The compounds of formula 1 are antibacterial agents that may be used to treat various bacterial and protozoa infections. The invention also relates to pharmaceutical compositions containing compounds prepared by the processes of the invention and to methods of treating bacterial protozoa infections by administering such compounds. |
| format | Patent |
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The invention relates to processes for preparing compounds of formula 1 wherein R is as defined herein, and to pharmaceutically acceptable salts thereof, as well as intermediates useful in such processes. The compounds of formula 1 are antibacterial agents that may be used to treat various bacterial and protozoa infections. The invention also relates to pharmaceutical compositions containing compounds prepared by the processes of the invention and to methods of treating bacterial protozoa infections by administering such compounds.</description><language>spa</language><subject>APPARATUS THEREFOR ; CHEMISTRY ; DERIVATIVES THEREOF ; GENERAL METHODS OF ORGANIC CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; NUCLEIC ACIDS ; NUCLEOSIDES ; NUCLEOTIDES ; ORGANIC CHEMISTRY ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SUGARS</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170417&DB=EPODOC&CC=ES&NR=2608848T3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170417&DB=EPODOC&CC=ES&NR=2608848T3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Hammen, Philip Dietrich</creatorcontrib><creatorcontrib>Lehner, Richard Shelton</creatorcontrib><creatorcontrib>Tucker, John Lloyd</creatorcontrib><creatorcontrib>Negri, Joanna Teresa</creatorcontrib><creatorcontrib>Wei, Lulin</creatorcontrib><title>Procedimiento de preparación de derivados 4''-sustituidos de 9-desoxo-9a-aza-9a-homoeritromicina A</title><description>Un procedimiento de preparación de un compuesto de fórmula 1a**Fórmula** o una sal farmacéuticamente aceptable del mismo, haciendo reaccionar un compuesto de fórmula 2**Fórmula** con n-propilamina en un disolvente orgánico que comprende isopropanol; en el que la reacción se lleva a cabo a una temperatura de al menos 40 °C.
The invention relates to processes for preparing compounds of formula 1 wherein R is as defined herein, and to pharmaceutically acceptable salts thereof, as well as intermediates useful in such processes. The compounds of formula 1 are antibacterial agents that may be used to treat various bacterial and protozoa infections. The invention also relates to pharmaceutical compositions containing compounds prepared by the processes of the invention and to methods of treating bacterial protozoa infections by administering such compounds.</description><subject>APPARATUS THEREFOR</subject><subject>CHEMISTRY</subject><subject>DERIVATIVES THEREOF</subject><subject>GENERAL METHODS OF ORGANIC CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>NUCLEIC ACIDS</subject><subject>NUCLEOSIDES</subject><subject>NUCLEOTIDES</subject><subject>ORGANIC CHEMISTRY</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SUGARS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2017</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNi0EKwjAQRbtxIeod4qqrgNgi6VKk4lIw-zIkIw6YTEhSEa_lEbyYDXgAV4_Hf39emXNkg5Ycoc8sLIoQMUAEQ5-3L24x0gMsJ9HWtUxjypRHKj6NnbSY-MmyAwkvKLix4-mSIzsy5EHsl9XsCveEqx8X1frY68NJYuABUwCDHvPQX7a7jVKt0rpp_mm-gyI-cg</recordid><startdate>20170417</startdate><enddate>20170417</enddate><creator>Hammen, Philip Dietrich</creator><creator>Lehner, Richard Shelton</creator><creator>Tucker, John Lloyd</creator><creator>Negri, Joanna Teresa</creator><creator>Wei, Lulin</creator><scope>EVB</scope></search><sort><creationdate>20170417</creationdate><title>Procedimiento de preparación de derivados 4''-sustituidos de 9-desoxo-9a-aza-9a-homoeritromicina A</title><author>Hammen, Philip Dietrich ; Lehner, Richard Shelton ; Tucker, John Lloyd ; Negri, Joanna Teresa ; Wei, Lulin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_ES2608848TT33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>spa</language><creationdate>2017</creationdate><topic>APPARATUS THEREFOR</topic><topic>CHEMISTRY</topic><topic>DERIVATIVES THEREOF</topic><topic>GENERAL METHODS OF ORGANIC CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>NUCLEIC ACIDS</topic><topic>NUCLEOSIDES</topic><topic>NUCLEOTIDES</topic><topic>ORGANIC CHEMISTRY</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SUGARS</topic><toplevel>online_resources</toplevel><creatorcontrib>Hammen, Philip Dietrich</creatorcontrib><creatorcontrib>Lehner, Richard Shelton</creatorcontrib><creatorcontrib>Tucker, John Lloyd</creatorcontrib><creatorcontrib>Negri, Joanna Teresa</creatorcontrib><creatorcontrib>Wei, Lulin</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Hammen, Philip Dietrich</au><au>Lehner, Richard Shelton</au><au>Tucker, John Lloyd</au><au>Negri, Joanna Teresa</au><au>Wei, Lulin</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Procedimiento de preparación de derivados 4''-sustituidos de 9-desoxo-9a-aza-9a-homoeritromicina A</title><date>2017-04-17</date><risdate>2017</risdate><abstract>Un procedimiento de preparación de un compuesto de fórmula 1a**Fórmula** o una sal farmacéuticamente aceptable del mismo, haciendo reaccionar un compuesto de fórmula 2**Fórmula** con n-propilamina en un disolvente orgánico que comprende isopropanol; en el que la reacción se lleva a cabo a una temperatura de al menos 40 °C.
The invention relates to processes for preparing compounds of formula 1 wherein R is as defined herein, and to pharmaceutically acceptable salts thereof, as well as intermediates useful in such processes. The compounds of formula 1 are antibacterial agents that may be used to treat various bacterial and protozoa infections. The invention also relates to pharmaceutical compositions containing compounds prepared by the processes of the invention and to methods of treating bacterial protozoa infections by administering such compounds.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | APPARATUS THEREFOR CHEMISTRY DERIVATIVES THEREOF GENERAL METHODS OF ORGANIC CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS |
| title | Procedimiento de preparación de derivados 4''-sustituidos de 9-desoxo-9a-aza-9a-homoeritromicina A |
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