5-Anilinoimidazopiridinas y métodos de uso
Un compuesto para su uso en un método para el tratamiento del cáncer que se selecciona entre: (2-hidroxietoxi)-amida del ácido 5-(2-fluoro-4-yodofenilamino)-imidazo[1,5-a]piridin-6-carboxílico; ((R)-2,3-dihidroxi-propoxi)-amida del ácido 5-(2-fluoro-4-yodo-fenilamino)-imidazo[1,5-a]piridin-6-carboxí...
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| creator | HEALD, ROBERT PRICE, STEPHEN LEE, WENDY ZAK, MARK E HEWITT, JOANNE FRANCES MARY |
| description | Un compuesto para su uso en un método para el tratamiento del cáncer que se selecciona entre: (2-hidroxietoxi)-amida del ácido 5-(2-fluoro-4-yodofenilamino)-imidazo[1,5-a]piridin-6-carboxílico; ((R)-2,3-dihidroxi-propoxi)-amida del ácido 5-(2-fluoro-4-yodo-fenilamino)-imidazo[1,5-a]piridin-6-carboxílico; ((S)-2-hidroxi-propoxi)-amida del ácido 5-(2-fluoro-4-yodo-fenilamino)-imidazo[1,5-a]piridin-6-carboxílico; (2-hidroxietoxi)-amida del ácido 5-(4-bromo-2-fluorofenilamino)-imidazo[1,5-a]piridin-6-carboxílico; ((S)-2-hidroxi-propoxi)-amida del ácido 5-(4-bromo-2-fluoro-fenilamino)-imidazo[1,5-a]piridin-6-carboxílico; ((S)-2-hidroxi-propoxi)-amida del ácido 5-(4-bromo-2-fluoro-fenilamino)-8-fluoro-imidazo[1,5-a]piridin-6- carboxílico; (2-hidroxi-etoxi)-amida del ácido 8-fluoro-5-(2-fluoro-4-yodo-fenilamino)-imidazo[1,5-a]piridin-6-carboxílico; ((R)-2,3-dihidroxi-propoxi)-amida del ácido 8-fluoro-5-(2-fluoro-4-yodo-fenilamino)-imidazo[1,5-a]piridin-6- carboxílico; ((S)-2-hidroxi-propoxi)-amida del ácido 8-fluoro-5-(2-fluoro-4-yodo-fenilamino)-imidazo[1,5-a]piridin-6-carboxílico; (2-hidroxi-etoxi)-amida del ácido 5-(2-fluoro-metanosulfanil-fenilamino)-imidazo[1,5-a]piridin-6-carboxílico; (2-hidroxi-etoxi)-amida del ácido 5-(2-fluoro-4-yodo-fenilamino)-imidazo[1,5-a]pirazina-6-carboxílico; ((S)-2-hidroxi-propoxi)-amida del ácido 5-(2-fluoro-4-yodo-fenilamino)-imidazo[1,5-a]pirazina-6-carboxílico; (2-hidroxi-etoxi)-amida del ácido 5-(4-ciclopropil-2-fluoro-fenilamino)-imidazo[1,5-a]piridin-6-carboxílico; (R) -N-(2,3-dihidroxipropoxi)-5-(2-fluoro-4-yodofenilamino)imidazo[1,5-a]pirazina-6-carboxamida; N-etoxi-5-(2-fluoro-4-yodofenilamino)imidazo[1,5-a]pirazina-6-carboxamida; N-(ciclopropilmetoxi)-5-(2-fluoro-4-yodofenilamino)imidazo[1,5-a]pirazina-6-carboxamida; 5-(2-fluoro-4-yodofenilamino)-N-metilimidazo[1,5-a]pirazina-6-carboxamida; 5-(4-bromo-2-fluorofenilamino)-N-(2-hidroxi-etoxi)imidazo[1,5-a]pirazina-6-carboxamida; (S)-5-(4-bromo-2-fluorofenilamino)-N-(2-hidroxi-propoxi)imidazo[1,5-a]pirazina-6-carboxamida; (R)-5-(4-bromo-2-fluorofenilamino)-N-(2,3-dihidroxi-propoxi)imidazo[1,5-a]pirazina-6-carboxamida; y 5-(4-bromo-2-fluorofenilamino)-N-(ciclopropil-metoxi)imidazo[1,5-a]pirazina-6-carboxamida; o una sal farmacéuticamente aceptable del mismo; comprendiendo el método administrar el compuesto junto con gemcitabina o un taxoide.
The invention relates to imidazopyridines of formula 1 with anti-cancer and/or anti-inflammatory activity and more specifically to im |
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The invention relates to imidazopyridines of formula 1 with anti-cancer and/or anti-inflammatory activity and more specifically to imidazopyridines which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth or treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.</description><language>spa</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2015</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150921&DB=EPODOC&CC=ES&NR=2546171T3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150921&DB=EPODOC&CC=ES&NR=2546171T3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HEALD, ROBERT</creatorcontrib><creatorcontrib>PRICE, STEPHEN</creatorcontrib><creatorcontrib>LEE, WENDY</creatorcontrib><creatorcontrib>ZAK, MARK E</creatorcontrib><creatorcontrib>HEWITT, JOANNE FRANCES MARY</creatorcontrib><title>5-Anilinoimidazopiridinas y métodos de uso</title><description>Un compuesto para su uso en un método para el tratamiento del cáncer que se selecciona entre: (2-hidroxietoxi)-amida del ácido 5-(2-fluoro-4-yodofenilamino)-imidazo[1,5-a]piridin-6-carboxílico; ((R)-2,3-dihidroxi-propoxi)-amida del ácido 5-(2-fluoro-4-yodo-fenilamino)-imidazo[1,5-a]piridin-6-carboxílico; ((S)-2-hidroxi-propoxi)-amida del ácido 5-(2-fluoro-4-yodo-fenilamino)-imidazo[1,5-a]piridin-6-carboxílico; (2-hidroxietoxi)-amida del ácido 5-(4-bromo-2-fluorofenilamino)-imidazo[1,5-a]piridin-6-carboxílico; ((S)-2-hidroxi-propoxi)-amida del ácido 5-(4-bromo-2-fluoro-fenilamino)-imidazo[1,5-a]piridin-6-carboxílico; ((S)-2-hidroxi-propoxi)-amida del ácido 5-(4-bromo-2-fluoro-fenilamino)-8-fluoro-imidazo[1,5-a]piridin-6- carboxílico; (2-hidroxi-etoxi)-amida del ácido 8-fluoro-5-(2-fluoro-4-yodo-fenilamino)-imidazo[1,5-a]piridin-6-carboxílico; ((R)-2,3-dihidroxi-propoxi)-amida del ácido 8-fluoro-5-(2-fluoro-4-yodo-fenilamino)-imidazo[1,5-a]piridin-6- carboxílico; ((S)-2-hidroxi-propoxi)-amida del ácido 8-fluoro-5-(2-fluoro-4-yodo-fenilamino)-imidazo[1,5-a]piridin-6-carboxílico; (2-hidroxi-etoxi)-amida del ácido 5-(2-fluoro-metanosulfanil-fenilamino)-imidazo[1,5-a]piridin-6-carboxílico; (2-hidroxi-etoxi)-amida del ácido 5-(2-fluoro-4-yodo-fenilamino)-imidazo[1,5-a]pirazina-6-carboxílico; ((S)-2-hidroxi-propoxi)-amida del ácido 5-(2-fluoro-4-yodo-fenilamino)-imidazo[1,5-a]pirazina-6-carboxílico; (2-hidroxi-etoxi)-amida del ácido 5-(4-ciclopropil-2-fluoro-fenilamino)-imidazo[1,5-a]piridin-6-carboxílico; (R) -N-(2,3-dihidroxipropoxi)-5-(2-fluoro-4-yodofenilamino)imidazo[1,5-a]pirazina-6-carboxamida; N-etoxi-5-(2-fluoro-4-yodofenilamino)imidazo[1,5-a]pirazina-6-carboxamida; N-(ciclopropilmetoxi)-5-(2-fluoro-4-yodofenilamino)imidazo[1,5-a]pirazina-6-carboxamida; 5-(2-fluoro-4-yodofenilamino)-N-metilimidazo[1,5-a]pirazina-6-carboxamida; 5-(4-bromo-2-fluorofenilamino)-N-(2-hidroxi-etoxi)imidazo[1,5-a]pirazina-6-carboxamida; (S)-5-(4-bromo-2-fluorofenilamino)-N-(2-hidroxi-propoxi)imidazo[1,5-a]pirazina-6-carboxamida; (R)-5-(4-bromo-2-fluorofenilamino)-N-(2,3-dihidroxi-propoxi)imidazo[1,5-a]pirazina-6-carboxamida; y 5-(4-bromo-2-fluorofenilamino)-N-(ciclopropil-metoxi)imidazo[1,5-a]pirazina-6-carboxamida; o una sal farmacéuticamente aceptable del mismo; comprendiendo el método administrar el compuesto junto con gemcitabina o un taxoide.
The invention relates to imidazopyridines of formula 1 with anti-cancer and/or anti-inflammatory activity and more specifically to imidazopyridines which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth or treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2015</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNA21XXMy8zJzMvPzM1MSazKL8gsykzJzEssVqhUyD28siQ_Jb9YISVVobQ4n4eBNS0xpziVF0pzMyi6uYY4e-imFuTHpxYXJCan5qWWxLsGG5mamBmaG4aEGBsTowYArVYqfw</recordid><startdate>20150921</startdate><enddate>20150921</enddate><creator>HEALD, ROBERT</creator><creator>PRICE, STEPHEN</creator><creator>LEE, WENDY</creator><creator>ZAK, MARK E</creator><creator>HEWITT, JOANNE FRANCES MARY</creator><scope>EVB</scope></search><sort><creationdate>20150921</creationdate><title>5-Anilinoimidazopiridinas y métodos de uso</title><author>HEALD, ROBERT ; PRICE, STEPHEN ; LEE, WENDY ; ZAK, MARK E ; HEWITT, JOANNE FRANCES MARY</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_ES2546171TT33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>spa</language><creationdate>2015</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>HEALD, ROBERT</creatorcontrib><creatorcontrib>PRICE, STEPHEN</creatorcontrib><creatorcontrib>LEE, WENDY</creatorcontrib><creatorcontrib>ZAK, MARK E</creatorcontrib><creatorcontrib>HEWITT, JOANNE FRANCES MARY</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HEALD, ROBERT</au><au>PRICE, STEPHEN</au><au>LEE, WENDY</au><au>ZAK, MARK E</au><au>HEWITT, JOANNE FRANCES MARY</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>5-Anilinoimidazopiridinas y métodos de uso</title><date>2015-09-21</date><risdate>2015</risdate><abstract>Un compuesto para su uso en un método para el tratamiento del cáncer que se selecciona entre: (2-hidroxietoxi)-amida del ácido 5-(2-fluoro-4-yodofenilamino)-imidazo[1,5-a]piridin-6-carboxílico; ((R)-2,3-dihidroxi-propoxi)-amida del ácido 5-(2-fluoro-4-yodo-fenilamino)-imidazo[1,5-a]piridin-6-carboxílico; ((S)-2-hidroxi-propoxi)-amida del ácido 5-(2-fluoro-4-yodo-fenilamino)-imidazo[1,5-a]piridin-6-carboxílico; (2-hidroxietoxi)-amida del ácido 5-(4-bromo-2-fluorofenilamino)-imidazo[1,5-a]piridin-6-carboxílico; ((S)-2-hidroxi-propoxi)-amida del ácido 5-(4-bromo-2-fluoro-fenilamino)-imidazo[1,5-a]piridin-6-carboxílico; ((S)-2-hidroxi-propoxi)-amida del ácido 5-(4-bromo-2-fluoro-fenilamino)-8-fluoro-imidazo[1,5-a]piridin-6- carboxílico; (2-hidroxi-etoxi)-amida del ácido 8-fluoro-5-(2-fluoro-4-yodo-fenilamino)-imidazo[1,5-a]piridin-6-carboxílico; ((R)-2,3-dihidroxi-propoxi)-amida del ácido 8-fluoro-5-(2-fluoro-4-yodo-fenilamino)-imidazo[1,5-a]piridin-6- carboxílico; ((S)-2-hidroxi-propoxi)-amida del ácido 8-fluoro-5-(2-fluoro-4-yodo-fenilamino)-imidazo[1,5-a]piridin-6-carboxílico; (2-hidroxi-etoxi)-amida del ácido 5-(2-fluoro-metanosulfanil-fenilamino)-imidazo[1,5-a]piridin-6-carboxílico; (2-hidroxi-etoxi)-amida del ácido 5-(2-fluoro-4-yodo-fenilamino)-imidazo[1,5-a]pirazina-6-carboxílico; ((S)-2-hidroxi-propoxi)-amida del ácido 5-(2-fluoro-4-yodo-fenilamino)-imidazo[1,5-a]pirazina-6-carboxílico; (2-hidroxi-etoxi)-amida del ácido 5-(4-ciclopropil-2-fluoro-fenilamino)-imidazo[1,5-a]piridin-6-carboxílico; (R) -N-(2,3-dihidroxipropoxi)-5-(2-fluoro-4-yodofenilamino)imidazo[1,5-a]pirazina-6-carboxamida; N-etoxi-5-(2-fluoro-4-yodofenilamino)imidazo[1,5-a]pirazina-6-carboxamida; N-(ciclopropilmetoxi)-5-(2-fluoro-4-yodofenilamino)imidazo[1,5-a]pirazina-6-carboxamida; 5-(2-fluoro-4-yodofenilamino)-N-metilimidazo[1,5-a]pirazina-6-carboxamida; 5-(4-bromo-2-fluorofenilamino)-N-(2-hidroxi-etoxi)imidazo[1,5-a]pirazina-6-carboxamida; (S)-5-(4-bromo-2-fluorofenilamino)-N-(2-hidroxi-propoxi)imidazo[1,5-a]pirazina-6-carboxamida; (R)-5-(4-bromo-2-fluorofenilamino)-N-(2,3-dihidroxi-propoxi)imidazo[1,5-a]pirazina-6-carboxamida; y 5-(4-bromo-2-fluorofenilamino)-N-(ciclopropil-metoxi)imidazo[1,5-a]pirazina-6-carboxamida; o una sal farmacéuticamente aceptable del mismo; comprendiendo el método administrar el compuesto junto con gemcitabina o un taxoide.
The invention relates to imidazopyridines of formula 1 with anti-cancer and/or anti-inflammatory activity and more specifically to imidazopyridines which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth or treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.</abstract><oa>free_for_read</oa></addata></record> |
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| title | 5-Anilinoimidazopiridinas y métodos de uso |
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