Síntesis de monosuccinato de solifenacina
Un método para producir succinato de solifenacina, que comprende permitir que reaccione ácido succínico con un compuesto representado por una fórmula (II) [en la fórmula, la estereoquímica de la posición 1 de la tetrahidroisoquinolina sustituida con fenilo es una mezcla de la forma (R) y la forma (S...
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| creator | ISHII, YUSUKE INAKOSHI, MASATOSHI |
| description | Un método para producir succinato de solifenacina, que comprende permitir que reaccione ácido succínico con un compuesto representado por una fórmula (II) [en la fórmula, la estereoquímica de la posición 1 de la tetrahidroisoquinolina sustituida con fenilo es una mezcla de la forma (R) y la forma (S) ], en el que el compuesto representado por la fórmula (II) es (3R) -quinuclidin-3-il éster del ácido (1RS) -1-fenil-1, 2, 3, 4tetrahidroisoquinolin-2-carboxílico.
There is provided a novel method for producing solifenacin or a salt thereof which is useful as a medicine, particularly a therapeutic agent and/or a preventive agent for a urinary organ system disease such as pollakiuria or urinary incontinence. Illustratively, there are provided (1) a method for producing solifenacin in which 2-(1H-imidazolylcarbonyl)-1-phenyltetrahydroisoquinoline is used as the starting material, (2) a method for producing solifenacin succinate in which (1RS)-phenyltetrahydroisoquinoline-carboxylic acid quinuclidinyl ester is used as the starting material, (3) a method for producing solifenacin in which a lower alkyl quinuclidinyl carbonate is used as the starting material and (4) a method for producing solifenacin in which phenyltetrahydroisoquinoline-carboxylic acid secondary lower alkyl or tertiary lower alkyl ester is used as the starting material and allowed to react with an alkali metal lower alkoxide. |
| format | Patent |
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There is provided a novel method for producing solifenacin or a salt thereof which is useful as a medicine, particularly a therapeutic agent and/or a preventive agent for a urinary organ system disease such as pollakiuria or urinary incontinence. Illustratively, there are provided (1) a method for producing solifenacin in which 2-(1H-imidazolylcarbonyl)-1-phenyltetrahydroisoquinoline is used as the starting material, (2) a method for producing solifenacin succinate in which (1RS)-phenyltetrahydroisoquinoline-carboxylic acid quinuclidinyl ester is used as the starting material, (3) a method for producing solifenacin in which a lower alkyl quinuclidinyl carbonate is used as the starting material and (4) a method for producing solifenacin in which phenyltetrahydroisoquinoline-carboxylic acid secondary lower alkyl or tertiary lower alkyl ester is used as the starting material and allowed to react with an alkali metal lower alkoxide.</description><language>spa</language><subject>APPARATUS THEREFOR ; CHEMISTRY ; GENERAL METHODS OF ORGANIC CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2012</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20121226&DB=EPODOC&CC=ES&NR=2393540T3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20121226&DB=EPODOC&CC=ES&NR=2393540T3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ISHII, YUSUKE</creatorcontrib><creatorcontrib>INAKOSHI, MASATOSHI</creatorcontrib><title>Síntesis de monosuccinato de solifenacina</title><description>Un método para producir succinato de solifenacina, que comprende permitir que reaccione ácido succínico con un compuesto representado por una fórmula (II) [en la fórmula, la estereoquímica de la posición 1 de la tetrahidroisoquinolina sustituida con fenilo es una mezcla de la forma (R) y la forma (S) ], en el que el compuesto representado por la fórmula (II) es (3R) -quinuclidin-3-il éster del ácido (1RS) -1-fenil-1, 2, 3, 4tetrahidroisoquinolin-2-carboxílico.
There is provided a novel method for producing solifenacin or a salt thereof which is useful as a medicine, particularly a therapeutic agent and/or a preventive agent for a urinary organ system disease such as pollakiuria or urinary incontinence. Illustratively, there are provided (1) a method for producing solifenacin in which 2-(1H-imidazolylcarbonyl)-1-phenyltetrahydroisoquinoline is used as the starting material, (2) a method for producing solifenacin succinate in which (1RS)-phenyltetrahydroisoquinoline-carboxylic acid quinuclidinyl ester is used as the starting material, (3) a method for producing solifenacin in which a lower alkyl quinuclidinyl carbonate is used as the starting material and (4) a method for producing solifenacin in which phenyltetrahydroisoquinoline-carboxylic acid secondary lower alkyl or tertiary lower alkyl ester is used as the starting material and allowed to react with an alkali metal lower alkoxide.</description><subject>APPARATUS THEREFOR</subject><subject>CHEMISTRY</subject><subject>GENERAL METHODS OF ORGANIC CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2012</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNAKPrw2ryS1OLNYISVVITc_L7-4NDk5My-xJB8kUJyfk5mWmpcIEuFhYE1LzClO5YXS3AyKbq4hzh66qQX58anFBYnJqXmpJfGuwUbGlsamJgYhIcbGxKgBAKjRKmA</recordid><startdate>20121226</startdate><enddate>20121226</enddate><creator>ISHII, YUSUKE</creator><creator>INAKOSHI, MASATOSHI</creator><scope>EVB</scope></search><sort><creationdate>20121226</creationdate><title>Síntesis de monosuccinato de solifenacina</title><author>ISHII, YUSUKE ; INAKOSHI, MASATOSHI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_ES2393540TT33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>spa</language><creationdate>2012</creationdate><topic>APPARATUS THEREFOR</topic><topic>CHEMISTRY</topic><topic>GENERAL METHODS OF ORGANIC CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>ISHII, YUSUKE</creatorcontrib><creatorcontrib>INAKOSHI, MASATOSHI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ISHII, YUSUKE</au><au>INAKOSHI, MASATOSHI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Síntesis de monosuccinato de solifenacina</title><date>2012-12-26</date><risdate>2012</risdate><abstract>Un método para producir succinato de solifenacina, que comprende permitir que reaccione ácido succínico con un compuesto representado por una fórmula (II) [en la fórmula, la estereoquímica de la posición 1 de la tetrahidroisoquinolina sustituida con fenilo es una mezcla de la forma (R) y la forma (S) ], en el que el compuesto representado por la fórmula (II) es (3R) -quinuclidin-3-il éster del ácido (1RS) -1-fenil-1, 2, 3, 4tetrahidroisoquinolin-2-carboxílico.
There is provided a novel method for producing solifenacin or a salt thereof which is useful as a medicine, particularly a therapeutic agent and/or a preventive agent for a urinary organ system disease such as pollakiuria or urinary incontinence. Illustratively, there are provided (1) a method for producing solifenacin in which 2-(1H-imidazolylcarbonyl)-1-phenyltetrahydroisoquinoline is used as the starting material, (2) a method for producing solifenacin succinate in which (1RS)-phenyltetrahydroisoquinoline-carboxylic acid quinuclidinyl ester is used as the starting material, (3) a method for producing solifenacin in which a lower alkyl quinuclidinyl carbonate is used as the starting material and (4) a method for producing solifenacin in which phenyltetrahydroisoquinoline-carboxylic acid secondary lower alkyl or tertiary lower alkyl ester is used as the starting material and allowed to react with an alkali metal lower alkoxide.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | APPARATUS THEREFOR CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | Síntesis de monosuccinato de solifenacina |
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