Péptidos y derivados tipo APL de Hsp60 y composiciones farmacéuticas
Péptidos de la proteína humana de estrés térmico de 60 kDa que constituyen epitopes para células T, así como péptidos derivados deellos, los cuales están modificados en los sitios de contacto con la molécula MHC, útiles para inducir mecanismos de tolerancia periférica, en particular mecanismos induc...
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| creator | LORENZO PEREZ, NORAILYS MORERA CORDOVA, VIVIAN PADRON PALOMARES, GABRIEL R DOMINGUEZ HORTA, MARIA DEL CARMEN LOPEZ MARIN, NELIA COSME DIAZ, CARELIA VAZQUEZ BONACHEA, ARIEL MERINO GARCIA, NELSON J HERNANDEZ GARCIA, ARIADNA BARBERA BETANCOURT, ARIANA SUAREZ ALBA, JOSE |
| description | Péptidos de la proteína humana de estrés térmico de 60 kDa que constituyen epitopes para células T, así como péptidos derivados deellos, los cuales están modificados en los sitios de contacto con la molécula MHC, útiles para inducir mecanismos de tolerancia periférica, en particular mecanismos inductores de anergia o mediados por clones de células T regulatorias en pacientes con Artritis Reumatoide. La invención también refiere composiciones farmacéuticas que comprenden tales péptidos para tratamiento de la Artritis Reumatoide.
Peptides of human heat shock protein of 60 kDa, that constitute epitopes for T cells, as well as their derived peptides, which are modified at the contact sites with the MHC molecule, are useful to induce mechanisms of peripheral tolerance, in particular mechanisms of anergy or mediated by clones of regulatory T cells in patients with Rheumatoid Arthritis. The invention also refers pharmaceutical compositions comprising such peptides for the treatment of Rheumatoid Arthritis. |
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Peptides of human heat shock protein of 60 kDa, that constitute epitopes for T cells, as well as their derived peptides, which are modified at the contact sites with the MHC molecule, are useful to induce mechanisms of peripheral tolerance, in particular mechanisms of anergy or mediated by clones of regulatory T cells in patients with Rheumatoid Arthritis. The invention also refers pharmaceutical compositions comprising such peptides for the treatment of Rheumatoid Arthritis.</description><language>spa</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2012</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120822&DB=EPODOC&CC=ES&NR=2386498T3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25562,76317</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120822&DB=EPODOC&CC=ES&NR=2386498T3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LORENZO PEREZ, NORAILYS</creatorcontrib><creatorcontrib>MORERA CORDOVA, VIVIAN</creatorcontrib><creatorcontrib>PADRON PALOMARES, GABRIEL R</creatorcontrib><creatorcontrib>DOMINGUEZ HORTA, MARIA DEL CARMEN</creatorcontrib><creatorcontrib>LOPEZ MARIN, NELIA</creatorcontrib><creatorcontrib>COSME DIAZ, CARELIA</creatorcontrib><creatorcontrib>VAZQUEZ BONACHEA, ARIEL</creatorcontrib><creatorcontrib>MERINO GARCIA, NELSON J</creatorcontrib><creatorcontrib>HERNANDEZ GARCIA, ARIADNA</creatorcontrib><creatorcontrib>BARBERA BETANCOURT, ARIANA</creatorcontrib><creatorcontrib>SUAREZ ALBA, JOSE</creatorcontrib><title>Péptidos y derivados tipo APL de Hsp60 y composiciones farmacéuticas</title><description>Péptidos de la proteína humana de estrés térmico de 60 kDa que constituyen epitopes para células T, así como péptidos derivados deellos, los cuales están modificados en los sitios de contacto con la molécula MHC, útiles para inducir mecanismos de tolerancia periférica, en particular mecanismos inductores de anergia o mediados por clones de células T regulatorias en pacientes con Artritis Reumatoide. La invención también refiere composiciones farmacéuticas que comprenden tales péptidos para tratamiento de la Artritis Reumatoide.
Peptides of human heat shock protein of 60 kDa, that constitute epitopes for T cells, as well as their derived peptides, which are modified at the contact sites with the MHC molecule, are useful to induce mechanisms of peripheral tolerance, in particular mechanisms of anergy or mediated by clones of regulatory T cells in patients with Rheumatoid Arthritis. The invention also refers pharmaceutical compositions comprising such peptides for the treatment of Rheumatoid Arthritis.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2012</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHALOLyyoCQzJb9YoVIhJbUosywRxC7JLMhXcAzwAQopeBQXmBkAZZPzcwvyizOTM_PzUosV0hKLchOTD68sLclMTizmYWBNS8wpTuWF0twMim6uIc4euqkF-fGpxQWJyal5qSXxrsFGxhZmJpYWISHGxsSoAQB19zSu</recordid><startdate>20120822</startdate><enddate>20120822</enddate><creator>LORENZO PEREZ, NORAILYS</creator><creator>MORERA CORDOVA, VIVIAN</creator><creator>PADRON PALOMARES, GABRIEL R</creator><creator>DOMINGUEZ HORTA, MARIA DEL CARMEN</creator><creator>LOPEZ MARIN, NELIA</creator><creator>COSME DIAZ, CARELIA</creator><creator>VAZQUEZ BONACHEA, ARIEL</creator><creator>MERINO GARCIA, NELSON J</creator><creator>HERNANDEZ GARCIA, ARIADNA</creator><creator>BARBERA BETANCOURT, ARIANA</creator><creator>SUAREZ ALBA, JOSE</creator><scope>EVB</scope></search><sort><creationdate>20120822</creationdate><title>Péptidos y derivados tipo APL de Hsp60 y composiciones farmacéuticas</title><author>LORENZO PEREZ, NORAILYS ; MORERA CORDOVA, VIVIAN ; PADRON PALOMARES, GABRIEL R ; DOMINGUEZ HORTA, MARIA DEL CARMEN ; LOPEZ MARIN, NELIA ; COSME DIAZ, CARELIA ; VAZQUEZ BONACHEA, ARIEL ; MERINO GARCIA, NELSON J ; HERNANDEZ GARCIA, ARIADNA ; BARBERA BETANCOURT, ARIANA ; SUAREZ ALBA, JOSE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_ES2386498TT33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>spa</language><creationdate>2012</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>LORENZO PEREZ, NORAILYS</creatorcontrib><creatorcontrib>MORERA CORDOVA, VIVIAN</creatorcontrib><creatorcontrib>PADRON PALOMARES, GABRIEL R</creatorcontrib><creatorcontrib>DOMINGUEZ HORTA, MARIA DEL CARMEN</creatorcontrib><creatorcontrib>LOPEZ MARIN, NELIA</creatorcontrib><creatorcontrib>COSME DIAZ, CARELIA</creatorcontrib><creatorcontrib>VAZQUEZ BONACHEA, ARIEL</creatorcontrib><creatorcontrib>MERINO GARCIA, NELSON J</creatorcontrib><creatorcontrib>HERNANDEZ GARCIA, ARIADNA</creatorcontrib><creatorcontrib>BARBERA BETANCOURT, ARIANA</creatorcontrib><creatorcontrib>SUAREZ ALBA, JOSE</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LORENZO PEREZ, NORAILYS</au><au>MORERA CORDOVA, VIVIAN</au><au>PADRON PALOMARES, GABRIEL R</au><au>DOMINGUEZ HORTA, MARIA DEL CARMEN</au><au>LOPEZ MARIN, NELIA</au><au>COSME DIAZ, CARELIA</au><au>VAZQUEZ BONACHEA, ARIEL</au><au>MERINO GARCIA, NELSON J</au><au>HERNANDEZ GARCIA, ARIADNA</au><au>BARBERA BETANCOURT, ARIANA</au><au>SUAREZ ALBA, JOSE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Péptidos y derivados tipo APL de Hsp60 y composiciones farmacéuticas</title><date>2012-08-22</date><risdate>2012</risdate><abstract>Péptidos de la proteína humana de estrés térmico de 60 kDa que constituyen epitopes para células T, así como péptidos derivados deellos, los cuales están modificados en los sitios de contacto con la molécula MHC, útiles para inducir mecanismos de tolerancia periférica, en particular mecanismos inductores de anergia o mediados por clones de células T regulatorias en pacientes con Artritis Reumatoide. La invención también refiere composiciones farmacéuticas que comprenden tales péptidos para tratamiento de la Artritis Reumatoide.
Peptides of human heat shock protein of 60 kDa, that constitute epitopes for T cells, as well as their derived peptides, which are modified at the contact sites with the MHC molecule, are useful to induce mechanisms of peripheral tolerance, in particular mechanisms of anergy or mediated by clones of regulatory T cells in patients with Rheumatoid Arthritis. The invention also refers pharmaceutical compositions comprising such peptides for the treatment of Rheumatoid Arthritis.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | Péptidos y derivados tipo APL de Hsp60 y composiciones farmacéuticas |
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