Vacunas contra la gripe que incluyen combinaciones de adyuvantes particulados e inmunopotenciadores
Una composición inmunogénica que comprende: (i) un antígeno del virus de la gripe que es un virus inactivado y comprende virus completos, virus fraccionados o antígenos de superficie purificados, o está en forma de virosomas; (ii) un adyuvante particulado insoluble que comprende una micropartícula p...
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| creator | DEL GUIDICE, GUISEPPE RAPPUOLI, RINO O'HAGAN, DEREK |
| description | Una composición inmunogénica que comprende: (i) un antígeno del virus de la gripe que es un virus inactivado y comprende virus completos, virus fraccionados o antígenos de superficie purificados, o está en forma de virosomas; (ii) un adyuvante particulado insoluble que comprende una micropartícula preparada a partir de poli(lactida-coglicolida); y (iii) un inmunopotenciador que es un oligonucleótido inmunoestimulante.
Influenza vaccines containing insoluble particulate adjuvants have been found to elicit an IgG response that is primarily a TH2 response (IgG1). This response can be shifted towards a TH1 response (IgG2a) by including immunopotentiators in the compositions. Thus the invention provides an immunogenic composition comprising: (i) an influenza virus antigen; (ii) an insoluble particulate adjuvant; and (iii) a immunopotentiator. |
| format | Patent |
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Influenza vaccines containing insoluble particulate adjuvants have been found to elicit an IgG response that is primarily a TH2 response (IgG1). This response can be shifted towards a TH1 response (IgG2a) by including immunopotentiators in the compositions. Thus the invention provides an immunogenic composition comprising: (i) an influenza virus antigen; (ii) an insoluble particulate adjuvant; and (iii) a immunopotentiator.</description><language>spa</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2012</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120402&DB=EPODOC&CC=ES&NR=2377884T3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120402&DB=EPODOC&CC=ES&NR=2377884T3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>DEL GUIDICE, GUISEPPE</creatorcontrib><creatorcontrib>RAPPUOLI, RINO</creatorcontrib><creatorcontrib>O'HAGAN, DEREK</creatorcontrib><title>Vacunas contra la gripe que incluyen combinaciones de adyuvantes particulados e inmunopotenciadores</title><description>Una composición inmunogénica que comprende: (i) un antígeno del virus de la gripe que es un virus inactivado y comprende virus completos, virus fraccionados o antígenos de superficie purificados, o está en forma de virosomas; (ii) un adyuvante particulado insoluble que comprende una micropartícula preparada a partir de poli(lactida-coglicolida); y (iii) un inmunopotenciador que es un oligonucleótido inmunoestimulante.
Influenza vaccines containing insoluble particulate adjuvants have been found to elicit an IgG response that is primarily a TH2 response (IgG1). This response can be shifted towards a TH1 response (IgG2a) by including immunopotentiators in the compositions. Thus the invention provides an immunogenic composition comprising: (i) an influenza virus antigen; (ii) an insoluble particulate adjuvant; and (iii) a immunopotentiator.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2012</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNi0sKAjEQRLNxIeod2gO4McLMXmZwb3A7tJ1WAplOzEeY2xvBA7gq6tWrtaIbUhXMQEFKQvAIz-Qiw6syOCFfF5Y2zncnSC4IZ7AMaJf6RimtRUzFUfVoQ4bvZ64SYigs5BpLnLdq9UCfeffLjdqPgzlfDhzDxDkisXCZhutRd13fn4zR-h_nAxGkQAU</recordid><startdate>20120402</startdate><enddate>20120402</enddate><creator>DEL GUIDICE, GUISEPPE</creator><creator>RAPPUOLI, RINO</creator><creator>O'HAGAN, DEREK</creator><scope>EVB</scope></search><sort><creationdate>20120402</creationdate><title>Vacunas contra la gripe que incluyen combinaciones de adyuvantes particulados e inmunopotenciadores</title><author>DEL GUIDICE, GUISEPPE ; RAPPUOLI, RINO ; O'HAGAN, DEREK</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_ES2377884TT33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>spa</language><creationdate>2012</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>DEL GUIDICE, GUISEPPE</creatorcontrib><creatorcontrib>RAPPUOLI, RINO</creatorcontrib><creatorcontrib>O'HAGAN, DEREK</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>DEL GUIDICE, GUISEPPE</au><au>RAPPUOLI, RINO</au><au>O'HAGAN, DEREK</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Vacunas contra la gripe que incluyen combinaciones de adyuvantes particulados e inmunopotenciadores</title><date>2012-04-02</date><risdate>2012</risdate><abstract>Una composición inmunogénica que comprende: (i) un antígeno del virus de la gripe que es un virus inactivado y comprende virus completos, virus fraccionados o antígenos de superficie purificados, o está en forma de virosomas; (ii) un adyuvante particulado insoluble que comprende una micropartícula preparada a partir de poli(lactida-coglicolida); y (iii) un inmunopotenciador que es un oligonucleótido inmunoestimulante.
Influenza vaccines containing insoluble particulate adjuvants have been found to elicit an IgG response that is primarily a TH2 response (IgG1). This response can be shifted towards a TH1 response (IgG2a) by including immunopotentiators in the compositions. Thus the invention provides an immunogenic composition comprising: (i) an influenza virus antigen; (ii) an insoluble particulate adjuvant; and (iii) a immunopotentiator.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | Vacunas contra la gripe que incluyen combinaciones de adyuvantes particulados e inmunopotenciadores |
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